Search Results - "Bastelica, D."
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C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
Published in Diabetologia (01-06-2007)“…Aims/hypothesis Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative…”
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Systemic inhibition and liver‐specific over‐expression of PAI‐1 failed to improve survival in all‐inclusive populations or homogenous cohorts of CLP mice
Published in Journal of thrombosis and haemostasis (01-06-2014)“…Summary Background The role of plasminogen activator inhibitor type‐1 (PAI‐1) in abdominal sepsis remains elusive. Objectives To study the influence of…”
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CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice
Published in International Journal of Obesity (01-06-2015)“…Background/objectives: Lymphocytes have a critical role in visceral adipose tissue (AT) inflammation. The CD28 costimulatory molecule is required for…”
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Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha
Published in The Journal of pathology (01-04-2008)“…TNFα (TNF) critically regulates inflammation-driven atherosclerosis. Because the transmembrane (tmTNF) and soluble (sTNF) forms of TNF possess distinct…”
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Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss
Published in Diabetologia (01-11-2001)“…Abdominal fat produces plasminogen activator inhibitor-1 (PAI-1) and could contribute to increased plasma PAI-1 values in human obesity associated with insulin…”
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Chronic plasminogen activator inhibitor‐1 (PAI‐1) overexpression dampens CD25+ lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung
Published in Journal of thrombosis and haemostasis (01-12-2007)“…Background: Plasma plasminogen activator inhibitor‐1 (PAI‐1) level rises during sepsis and confers a worse prognosis. PAI‐1 participation to sepsis has been…”
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Influence of t-pA and u-PA on adipose tissue development in a murine model of diet-induced obesity
Published in Thrombosis and haemostasis (01-02-2002)“…To investigate the potential role of tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA) in development of adipose tissue,…”
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B010 Inhibition of furin by PAI-1: a potential role in metabolic syndrome
Published in Archives of cardiovascular diseases (2009)“…Metabolic Syndrome (MS) predisposes to type 2 diabetes (T2D) and coronary heart disease (CAD). Elevated levels of the serpin PAI-1 are observed in MS, and…”
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O79 Rôle du CD28 dans le développement de l’état inflammatoire et des complications métaboliques associés à l’obésité
Published in Diabetes & metabolism (26-03-2013)“…Rationnel Le lymphocyte T (LyT) participe à l’inflammation du tissu adipeux (TA) Son activation fait intervenir le système de costimulation CD28/B7. La…”
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Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity
Published in Diabetes (New York, N.Y.) (01-08-2000)“…Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. M C Alessi ,…”
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Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation
Published in Arteriosclerosis, thrombosis, and vascular biology (01-07-2003)“…OBJECTIVE—Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between the degree of LS…”
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Stromal Cells Are the Main Plasminogen Activator Inhibitor-1-Producing Cells in Human Fat: Evidence of Differences Between Visceral and Subcutaneous Deposits
Published in Arteriosclerosis, thrombosis, and vascular biology (01-01-2002)“…Elevated plasma plasminogen activator inhibitor (PAI)-1 observed during insulin resistance has been connected with an excessive PAI-1 adipose tissue secretion…”
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ID: 282 PAI-1 modulates the inflammatory response during Lipopolysaccharide (LPS)-induced endotoxemia
Published in Journal of thrombosis and haemostasis (01-10-2006)Get full text
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Adipose tissue and atherothrombosis
Published in Pathophysiology of haemostasis and thrombosis (01-01-2003)“…Obesity is associated with increased cardiovascular mortality and morbidity mainly through insulin resistance. Dysregulation of protein secretion by adipose…”
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B010 Inhibition of furin by PAI-1: a potential role in metabolic syndrome
Published in Archives of cardiovascular diseases (01-03-2009)Get full text
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