Search Results - "Basta, Leighanne A. Brammer"

Defining critical residues for substrate binding to 1‐deoxy‐d‐xylulose 5‐phosphate synthase – active site substitutions stabilize the predecarboxylation intermediate C2α‐lactylthiamin diphosphate by Brammer Basta, Leighanne A., Patel, Hetalben, Kakalis, Lazaros, Jordan, Frank, Freel Meyers, Caren L.

“…1‐Deoxy‐d‐xylulose 5‐phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and d‐glyceraldehyde 3‐phosphate (GraP) in a thiamin…”
Get full text

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem by Bianchet, Mario A., Pan, Ying H., Basta, Leighanne A. Brammer, Saavedra, Harry, Lloyd, Evan P., Kumar, Pankaj, Mattoo, Rohini, Townsend, Craig A., Lamichhane, Gyanu

“…Background The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of…”
Get full text

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β‑Lactamase Inhibitors by Gupta, Rashmi, Al-Kharji, Noora M. S. A, Alqurafi, Maha A, Nguyen, Thu Q, Chai, Weirui, Quan, Pojun, Malhotra, Riya, Simcox, Breven S, Mortimer, Phil, Brammer Basta, Leighanne A, Rohde, Kyle H, Buynak, John D

“…Commercial carbapenem antibiotics are being used to treat multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis. Like other β-lactams,…”
Get full text

Phylogenetic and Biochemical Analyses of Mycobacterial l,d-Transpeptidases Reveal a Distinct Enzyme Class That Is Preferentially Acylated by Meropenem by Zandi, Trevor A, Marshburn, Robert L, Stateler, Paige K, Brammer Basta, Leighanne A

“…The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent…”
Get full text

Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis by Brammer Basta, Leighanne A., Ghosh, Anita, Pan, Ying, Jakoncic, Jean, Lloyd, Evan P., Townsend, Craig A., Lamichhane, Gyanu, Bianchet, Mario A.

“…The final step of peptidoglycan (PG) biosynthesis in bacteria involves cross-linking of peptide side chains. This step in Mycobacterium tuberculosis is…”
Get full text

Efficient synthesis for each of the eight stereoisomers of the iminosugars lentiginosine and 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) by Liotta, Louis J., Antoine, Jessica, Brammer Basta, Leighanne A., Campbell, Andrew S., Cole, Gabrielle Y., Demick Brazile, Kristen A., Dogal Gardner, Natalie M., Fitzgerald, Megan E., Francois, Jean E.K., French, Brian M., Garafola, Sara L., Giannetti, Catherine A., Granatosky, Eve A., Harney, Alycen M., Hummel, James T., Joyce, Andrew P., Keylor, Mitchell H., Khubchandani, Jasmine A., Korzeniecki, Claudia, Lieberman, Diana C., Litterio, Joshua M., Maiorano, Madison O., Marshall, Jessica F., McCarthy, Kelly A., Mendes Vieira, Andreia, Miller, Ruby M., Morrison, Emily R., Moura, Steven P., Neumann, Dillon F., Oliveira, Aliza F., Pace, Nicholas J., Plouffe, Jodie X., Pomfret, Meredith N., Reardon, Katelyn N., Sheller-Miller, Samantha M., Smith, Michael J., Sullivan, Jessica L., Sweeney, Samantha W., Tougas, Kerstin L.

“…Herein, we describe the efficient, diastereoselective syntheses of the iminosugars 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) 1b, lentiginosine 3a, and the seven…”
Get full text

Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2[alpha]-lactylthiamin diphosphate by Brammer Basta, Leighanne A, Patel, Hetalben, Kakalis, Lazaros, Jordan, Frank, Freel Meyers, Caren L

“…1-Deoxy-d-xylulose 5-phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (GraP) in a thiamin…”
Get full text

Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase: Active site substitutions stabilize the pre-decarboxylation intermediate C2α-lactylthiamin diphosphate by Basta, Leighanne A. Brammer, Patel, Hetalben, Kakalis, Lazaros, Jordan, Frank, Meyers, Caren L. Freel

“…1-Deoxy- d -xylulose 5-phosphate (DXP) synthase catalyzes formation of DXP from pyruvate and d -glyceraldehyde 3-phosphate ( d -GAP) in a thiamin diphosphate…”
Get full text

Loss of a Functionally and Structurally Distinct ld-Transpeptidase, Ldt Mt5 , Compromises Cell Wall Integrity in Mycobacterium tuberculosis by Brammer Basta, Leighanne A., Ghosh, Anita, Pan, Ying, Jakoncic, Jean, Lloyd, Evan P., Townsend, Craig A., Lamichhane, Gyanu, Bianchet, Mario A.

Get full text

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt Mt2 by biapenem and tebipenem by Bianchet, Mario A, Pan, Ying H, Basta, Leighanne A Brammer, Saavedra, Harry, Lloyd, Evan P, Kumar, Pankaj, Mattoo, Rohini, Townsend, Craig A, Lamichhane, Gyanu

“…The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams,…”
Get full text