Search Results - "Bast, Darrin J."

Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia by Davidson, Ross, Cavalcanti, Rodrigo, Brunton, James L, Bast, Darrin J, de Azavedo, Joyce C.S, Kibsey, Pamela, Fleming, Christine, Low, Donald E

“…This report describes four patients with pneumococcal pneumonia in whom empirical treatment with levofloxacin failed. In these patients, the isolates of…”
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A Nosocomial Outbreak of Fluoroquinolone-Resistant Streptococcus pneumoniae by Weiss, Karl, Restieri, C., Gauthier, Richard, Laverdière, Michel, McGeer, Allison, Davidson, Ross J., Kilburn, Laurie, Bast, Darrin J., de Azavedo, Joyce, Low, Donald E.

“…Over the course of a 20-month period, in a hospital respiratory ward in which ciprofloxacin was often used as empirical antimicrobial therapy for lower…”
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Role for sagA and siaA in Quorum Sensing and Iron Regulation in Streptococcus pyogenes by Salim, Kowthar Y, de Azavedo, Joyce C, Bast, Darrin J, Cvitkovitch, Dennis G

“…Streptococcus pyogenes is a ubiquitous and versatile pathogen that causes a variety of infections with a wide range of severity. The versatility of this…”
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Identification of Group A Streptococcus Antigenic Determinants Upregulated In Vivo by Salim, Kowthar Y, Cvitkovitch, Dennis G, Chang, Peter, Bast, Darrin J, Handfield, Martin, Hillman, Jeffrey D, de Azavedo, Joyce C. S

“…Group A Streptococcus (GAS) causes a range of diseases in humans, from mild noninvasive infections to severe invasive infections. The molecular basis for the…”
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Novel Murine Model of Pneumococcal Pneumonia: Use of Temperature as a Measure of Disease Severity To Compare the Efficacies of Moxifloxacin and Levofloxacin by BAST, Darrin J, YUE, M, CHEN, X, BELL, D, DRESSER, L, SASKIN, R, MANDELL, L. A, LOW, D. E, DE AZAVEDO, Joyce C. S

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Identification of a Streptolysin S-Associated Gene Cluster and Its Role in the Pathogenesis of Streptococcus iniae Disease by FULLER, Jeffrey D, CAMUS, Alvin C, DUNCAN, Carla L, NIZET, Victor, BAST, Darrin J, THUNE, Ronald L, LOW, Donald E, DE AZAVEDO, Joyce C. S

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Streptococcus iniae Virulence Is Associated with a Distinct Genetic Profile by FULLER, Jeffrey D, BAST, Darrin J, NIZET, Victor, LOW, Donald E, DE AZAVEDO, Joyce C. S

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Prevalence and Characterization of Invasive Isolates of Streptococcus pyogenes with Reduced Susceptibility to Fluoroquinolones by POWIS, Jeff, MCGEER, Allison, LOW, Donald E, DUNCAN, Carla, GOREN, Ryan, DE AZAVEDO, Joyce C. S, BAST, Darrin J, PONG-PORTER, Sylvia, MAZZULLI, Tony, GREEN, Karen, WILLEY, Barbara

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Is In Vitro Antibiotic Combination More Effective than Single-Drug Therapy against Anthrax? by ATHAMNA, Abed, ATHAMNA, Muhammad, NURA, Aburashed, SHLYAKOV, Eli, BAST, Darrin J, FARRELL, David, RUBINSTEIN, Ethan

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Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae by BAST, Darrin J, DE AZAVEDO, Joyce C. S, TAM, Tiffany Y, KILBURN, Laurie, DUNCAN, Carla, MANDELL, Lionel A, DAVIDSON, Ross J, LOW, Donald E

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Streptolysin S and necrotising infections produced by group G streptococcus by Humar, Deepali, Datta, Vivekananda, Bast, Darrin J, Beall, Bernard, De Azavedo, Joyce CS, Nizet, Victor

“…We encountered three patients with severe necrotising soft tissue infections due to β-haemolytic group G streptococcus. Due to strong clinical similarities…”
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Genetic Locus for Streptolysin S Production by Group A Streptococcus by NIZET, V, BEALL, B, BAST, D. J, DATTA, V, KILBURN, L, LOW, D. E, DE AZAVEDO, J. C. S

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Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes by Salim, Kowthar Y, de Azavedo, Joyce C, Bast, Darrin J, Cvitkovitch, Dennis G

“…SilCR, a 17 amino acid putative signaling peptide, was proposed to modulate gene expression in Streptococcus pyogenes. We showed that SilCR added exogenously…”
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Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae : Contributions of type II topoisomerase mutations and efflux to levels of resistance by BAST, Darrin J, LOW, Donald E, DUNCAN, Carla L, KILBURN, Laurie, MANDELL, Lionel A, DAVIDSON, Ross J, DE AZAVEDO, Joyce C. S

“…We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux…”
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Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance by Bast, Darrin J., Athamna, Abed, Duncan, Carla L., de Azavedo, Joyce C. S., Low, Donald E., Rahav, Galia, Farrell, David, Rubinstein, Ethan

“…Objectives: To identify and characterize the mechanisms of high-level fluoroquinolone resistance in two strains of Bacillus anthracis following serial passage…”
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two-component system sivS/R regulates virulence in Streptococcus iniae by Bolotin, Shelly, Fuller, Jeffrey D, Bast, Darrin J, de Azavedo, Joyce C.S

“…Streptococcus iniae causes invasive disease and death in fish, and to a lesser extent, sporadic cases of soft-tissue infections in humans. A two-component…”
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Capsule expression regulated by a two-component signal transduction system in Streptococcus iniae by Bolotin, Shelly, Fuller, Jeffrey D, Bast, Darrin J, Beveridge, Terry J, de Azavedo, Joyce C.S

“…Streptococcus iniae causes disease in fish and humans and the presence of capsule is associated with virulence. Tn917 transposon mutagenesis was performed to…”
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Fluoroquinolone Resistance in Clinical Isolates ofStreptococcus pneumoniae: Contributions of Type II Topoisomerase Mutations and Efflux to Levels of Resistance by Bast, Darrin J, Low, Donald E, Duncan, Carla L, Kilburn, Laurie, Mandell, Lionel A, Davidson, Ross J, de Azavedo, Joyce C. S

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Quinolone Resistance: Older Concepts and Newer Developments by Bast, Darrin J., de Azavedo, Joyce C. S.

“…New quinolone compounds have been recommended for use in the treatment of respiratory tract infections, particularly pneumonia caused by multi drug-resistant…”
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The two-component system sivS/R regulates virulence in Streptococcus iniae: A TCS regulates virulence in Streptococcus iniae by Bolotin, Shelly, Fuller, Jeffrey D., Bast, Darrin J., de Azavedo, Joyce C.S.

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