Search Results - "Basson, Craig"

TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial by Svensson, Eric C, Madar, Aviv, Campbell, Catarina D, He, Yunsheng, Sultan, Marc, Healey, Margaret L, Xu, Huilei, D'Aco, Katie, Fernandez, Anita, Wache-Mainier, Clarisse, Libby, Peter, Ridker, Paul M, Beste, Michael T, Basson, Craig T

“…Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of atherosclerotic cardiovascular disease, and mouse experiments…”
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Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance by Choudhury, Robin P., DM, Birks, Jacqueline S., MSc, Mani, Venkatesh, PhD, Biasiolli, Luca, PhD, Robson, Matthew D., PhD, L'Allier, Philippe L., MD, Gingras, Marc-Alexandre, Alie, Nadia, BS, McLaughlin, Mary Ann, MD, Basson, Craig T., MD, PhD, Schecter, Alison D., MD, Svensson, Eric C., MD, PhD, Zhang, Yiming, PhD, Yates, Denise, PhD, Tardif, Jean-Claude, MD, Fayad, Zahi A., PhD

“…Abstract Background Evidence suggests that interleukin (IL)-1β is important in the pathogenesis of atherosclerosis and its complications and that inhibiting…”
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LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia by Rader, Daniel J, Maratos-Flier, Eleftheria, Nguyen, Amanda, Hom, Doug, Ferriere, Michael, Li, Yifang, Kompa, Jill, Martic, Miljen, Hinder, Markus, Basson, Craig T, Yowe, David, Diener, John, Goldfine, Allison B

“…To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant of human fibroblast growth factor-21, for triglyceride lowering,…”
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Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double‐blind, phase 2 trial by Tan, Susanne, Ignatenko, Stanislav, Wagner, Frank, Dokras, Anuja, Seufert, Jochen, Zwanziger, Denise, Dunschen, Karin, Zakaria, Marjorie, Huseinovic, Neda, Basson, Craig T., Mahling, Ping, Fuhrer, Dagmar, Hinder, Markus

“…Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. The dual sodium‐glucose co‐transporter 1/2 inhibitor (SGLT1/2i)…”
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MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans by Koch, Alexander W., Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Côté, Serge, DeGagne, Julie, Krantz, Carsten, Eder, Jörg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David L., Hoffmann, Peter, Basson, Craig T., Frost, Robert J.A., Khder, Yasser

“…A large unmet medical need exists for safer antithrombotic drugs because all currently approved anticoagulant agents interfere with hemostasis, leading to an…”
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Genetic basis for congenital heart defects: Current knowledge : A scientific statement from the american heart association congenital cardiac defects committee, council on cardiovascular disease in the young by PIERPONT, Mary Ella, BASSON, Craig T, BENSON, D. Woodrow, GELB, Bruce D, GIGLIA, Therese M, GOLDMUNTZ, Elizabeth, MCGEE, Glenn, SABLE, Craig A, SRIVASTAVA, Deepak, WEBB, Catherine L

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Mutant Desmocollin-2 Causes Arrhythmogenic Right Ventricular Cardiomyopathy by Heuser, Arnd, Plovie, Eva R., Ellinor, Patrick T., Grossmann, Katja S., Shin, Jordan T., Wichter, Thomas, Basson, Craig T., Lerman, Bruce B., Sasse-Klaassen, Sabine, Thierfelder, Ludwig, MacRae, Calum A., Gerull, Brenda

“…Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically heterogeneous heart-muscle disorder characterized by progressive fibrofatty replacement…”
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Aortic Dissection in Patients With Genetically Mediated Aneurysms: Incidence and Predictors in the GenTAC Registry by Weinsaft, Jonathan W, Devereux, Richard B, Preiss, Liliana R, Feher, Attila, Roman, Mary J, Basson, Craig T, Geevarghese, Alexi, Ravekes, William, Dietz, Harry C, Holmes, Kathryn, Habashi, Jennifer, Pyeritz, Reed E, Bavaria, Joseph, Milewski, Karianna, LeMaire, Scott A, Morris, Shaine, Milewicz, Dianna M, Prakash, Siddharth, Maslen, Cheryl, Song, Howard K, Silberbach, G Michael, Shohet, Ralph V, McDonnell, Nazli, Hendershot, Tabitha, Eagle, Kim A, Asch, Federico M

“…Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern…”
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Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction by Greenspan, Daniel S, Sato, Thomas N, Kobayashi, Koichi, Luo, Min, Zhang, Yue, Wilkes, David C, Ge, Gaoxiang, Grieskamp, Thomas, Yamada, Chikaomi, Liu, Ting-Chun, Huang, Guorui, Basson, Craig T, Kispert, Andreas

“…Secreted frizzled-related proteins (sFRPs) were reported to antagonise Chordin processing by Sizzled, a tolloid-like metalloproteinase in Xenopus and…”
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Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy by Schulze-Bahr, Eric, Ellinor, Patrick T, McDermott, Deborah A, Birchmeier, Walter, Sasse-Klaassen, Sabine, Gerull, Brenda, Markowitz, Steve M, Lerman, Bruce B, MacRae, Calum A, Thierfelder, Ludwig, Dietz, Rainer, Basson, Craig T, Wichter, Thomas, Paul, Matthias, Heuser, Arnd, Peters, Stefan, Grossmann, Katja S, Michely, Beate, Breithardt, Günter

“…Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with fibrofatty replacement of cardiac myocytes, ventricular tachyarrhythmias and sudden…”
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Specification of the Cardiac Conduction System by Transcription Factors by Hatcher, Cathy J, Basson, Craig T

“…Diseases of the cardiovascular system that cause sudden cardiac deaths are often caused by lethal arrhythmias that originate from defects in the cardiac…”
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Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells by Fraidenraich, Diego, Stillwell, Elizabeth, Romero, Elizabeth, Wilkes, David, Manova, Katia, Basson, Craig T., Benezra, Robert

“…We report that Id knockout mouse embryos display multiple cardiac defects, but mid-gestation lethality is rescued by the injection of 15 wild-type embryonic…”
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The molecular genetics of congenital heart disease: a review of recent developments by Wolf, Michael, Basson, Craig T

“…PURPOSE OF REVIEWOur understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic…”
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Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update: A Scientific Statement From the American Heart Association by Ganesh, Santhi K, Arnett, Donna K, Assimes, Thermistocles L, Basson, Craig T, Chakravarti, Aravinda, Ellinor, Patrick T, Engler, Mary B, Goldmuntz, Elizabeth, Herrington, David M, Hershberger, Ray E, Hong, Yuling, Johnson, Julie A, Kittner, Steven J, McDermott, Deborah A, Meschia, James F, Mestroni, Luisa, O’Donnell, Christopher J, Psaty, Bruce M, Vasan, Ramachandran S, Ruel, Marc, Shen, Win-Kuang, Terzic, Andre, Waldman, Scott A

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A randomized, placebo-controlled trial of canakinumab in patients with peripheral artery disease by Russell, Kerry S, Yates, Denise P, Kramer, Christopher M, Feller, Andrea, Mahling, Ping, Colin, Laurence, Clough, Timothy, Wang, Tianke, LaPerna, Lucy, Patel, Alpa, Lawall, Holger, Shennak, Mustafa M, Fulmer, James, Nikol, Sigrid, Smith, William B, Müller, Oliver J, Ratchford, Elizabeth V, Basson, Craig T

“…Extensive atherosclerotic plaque burden in the lower extremities often leads to symptomatic peripheral artery disease (PAD) including impaired walking…”
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Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia by Ip, James E., Xu, Linna, Dai, Jie, Steegborn, Clemens, Jaffré, Fabrice, Evans, Todd, Cheung, Jim W., Basson, Craig T., Panaghie, Gianina, Krogh-Madsen, Trine, Abbott, Geoffrey W., Lerman, Bruce B.

“…[Figure: see text]…”
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Relevance of genetics and genomics for prevention and treatment of cardiovascular disease : A scientific statement from the american heart association council on epidemiology and prevention, the stroke council, and the functional genomics and translational biology interdisciplinary working group by ARNETT, Donna K, BAIRD, Alison E, O'DONNELL, Christopher J, BARKLEY, Ruth A, BASSON, Craig T, BOERWINKLE, Eric, GANESH, Santhi K, HERRINGTON, David M, YULING HONG, JAQUISH, Cashell, MCDERMOTT, Deborah A

“…Atherosclerotic cardiovascular disease (CVD) is a major health problem in the United States and around the world. Evidence accumulated over decades…”
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Impact of Image Analysis Methodology on Diagnostic and Surgical Classification of Patients With Thoracic Aortic Aneurysms by Mendoza, Dorinna D., MD, Kochar, Minisha, MD, Devereux, Richard B., MD, Basson, Craig T., MD, PhD, Min, James K., MD, Holmes, Kathryn, MD, Dietz, Harry C., MD, Milewicz, Dianna M., MD, PhD, LeMaire, Scott A., MD, Pyeritz, Reed E., MD, PhD, Bavaria, Joseph E., MD, Maslen, Cheryl L., PhD, Song, Howard, MD, PhD, Kroner, Barbara L., PhD, Eagle, Kim A., MD, Weinsaft, Jonathan W., MD

“…Background For patients with thoracic aortic aneurysms (TAA), aortic size on imaging is widely used to guide clinical decision making. This study examined the…”
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Tbx5 Is Required for Avian and Mammalian Epicardial Formation and Coronary Vasculogenesis by Diman, Nata Y.S.-G, Brooks, Gabriel, Kruithof, Boudewijn P.T, Elemento, Olivier, Seidman, J.G, Seidman, Christine E, Basson, Craig T, Hatcher, Cathy J

“…RATIONALE:Holt–Oram syndrome is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene. Overexpression of Tbx5 in the chick…”
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Clinical phenotypes and molecular genetic mechanisms of Carney complex by Wilkes, David, McDermott, Deborah A, Basson, Craig T

“…Carney complex is a familial multiple neoplasia disorder with characteristic features such as cardiac and cutaneous myxomas and spotty pigmentation of the…”
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