Search Results - "Basso, M D"

The Neuropathological and Behavioral Consequences of Intraspinal Microglial/Macrophage Activation by POPOVICH, P G, GUAN, Z, MCGAUGHY, V, FISHER, L, HICKEY, W F, BASSO, D M

“…Activated microglia and macrophages (CNS macrophages) have been implicated in the secondary or “bystander” pathology (e.g. axon injury, demyelination) that…”
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von Frey anesthesiometry to assess sensory impairment after acute spinal cord injury caused by thoracolumbar intervertebral disc extrusion in dogs by Song, R.B., Basso, D.M., da Costa, R.C., Fisher, L.C., Mo, X., Moore, S.A.

“…•We compared sensory threshold (ST) values obtained from normal dogs with those from dogs with acute spinal cord injury (SCI).•Pelvic limb ST values were…”
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A sensitive and reliable locomotor rating scale for open field testing in rats by Basso, D M, Beattie, M S, Bresnahan, J C

“…Behavioral assessment after spinal cord contusion has long focused on open field locomotion using modifications of a rating scale developed by Tarlov and…”
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Behavioral testing in animal models of spinal cord injury by Fouad, K., Ng, C., Basso, D.M.

“…This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored Spinal Cord Injury Training Program at Ohio State University. We…”
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GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II‐mediated pressor responses in Sprague–Dawley rats by Leik, C E, Carson, N L, Hennan, J K, Basso, M D, Liu, Q‐Y, Crandall, D L, Nambi, P

“…Background and purpose: Liver X receptors (LXRs) activate genes that regulate lipid and cholesterol metabolism. LXR agonists were shown recently to also…”
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Graded Histological and Locomotor Outcomes after Spinal Cord Contusion Using the NYU Weight-Drop Device versus Transection by Basso, D.Michele, Beattie, Michael S., Bresnahan, Jacqueline C.

“…Injury reproducibility is an important characteristic of experimental models of spinal cord injuries (SCI) because it limits the variability in locomotor and…”
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Protein kinase C effects on nerve function, perfusion, Na+, K+-ATPase activity and glutathione content in diabetic rats by CAMERON, N. E, COTTER, M. A, JACK, A. M, BASSO, HOHMAN, T. C

“…Increased protein kinase C activity has been linked to diabetic vascular complications in the retina and kidney, which were attenuated by protein kinase C…”
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Neuroanatomical Substrates of Functional Recovery After Experimental Spinal Cord Injury: Implications of Basic Science Research for Human Spinal Cord Injury by Basso, D M

“…Human spinal cord injury (SCI) is a devastating condition that results in persistent motor deficits. Considerable basic and clinical research is directed at…”
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Analysis of anticaries potential of pit and fissures sealants containing amorphous calcium phosphate using synchrotron microtomography by Delben, A C B, Cannon, M, Vieira, A E M, Basso, M D, Danelon, M, Santo, M R E, Stock, S R, Xiao, X, De Carlo, F

“…The aim of this study was to analyze the anticaries potential of pit and fissure sealants containing amorphous calcium phosphate (ACP) by synchrotron…”
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Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice by Basso, M.D, Nambi, P, Adelman, S.J

“…Chronic inflammatory responses involving the immune system have been implicated in the process of atherosclerosis. Sirolimus (Rapamycin, Rapamune®), a potent…”
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Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice by Hansen, Christopher N, Fisher, Lesley C, Deibert, Rochelle J, Jakeman, Lyn B, Zhang, Haoqian, Noble-Haeusslein, Linda, White, Susan, Basso, D Michele

“…Spinal cord injury results in distant pathology around putative locomotor networks that may jeopardize the recovery of locomotion. We previously showed that…”
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A simplified method of walking track analysis to assess short-term locomotor recovery after acute spinal cord injury caused by thoracolumbar intervertebral disc extrusion in dogs by Song, R.B., Oldach, M.S., Basso, D.M., da Costa, R.C., Fisher, L.C., Mo, X., Moore, S.A.

“…•Stride length (SL) and base of support (BS) were compared in normal and SCI-affected dogs.•SL and BS were consistent across three testing sessions in normal…”
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Adult Opossums (Didelphis virginiana) Demonstrate Near Normal Locomotion after Spinal Cord Transection as Neonates by Wang, X.M., Basso, D.M., Terman, J.R., Bresnahan, J.C., Martin, G.F.

“…When the thoracic spinal cord of the North American opossum (Didelphis virginiana) is transected on postnatal day (PD) 5, the site of injury becomes bridged by…”
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Behavioral and Histological Outcomes Following Graded Spinal Cord Contusion Injury in the C57Bl/6 Mouse by Ma, Manhong, Basso, D.Michele, Walters, Patricia, Stokes, Bradford T., Jakeman, Lyn B.

“…A computer-controlled electromagnetic spinal cord injury device (ESCID) has been adapted to develop a mouse model of spinal cord contusion injury. In the…”
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Passive or Active Immunization with Myelin Basic Protein Impairs Neurological Function and Exacerbates Neuropathology after Spinal Cord Injury in Rats by Jones, T. Bucky, Ankeny, Daniel P, Guan, Zhen, McGaughy, Violeta, Fisher, Lesley C, Basso, D. Michele, Popovich, Phillip G

“…Myelin-reactive T-cells are activated by traumatic spinal cord injury (SCI) in rodents and humans. Despite the historical association of these cells with…”
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Diabetic-like retinopathy: early and late intervention therapies in galactose-fed rats by Robison, WG, Jr, Jacot, JL, Glover, JP, Basso, MD, Hohman, TC

“…To determine whether the diabetic-like thickening of retinal capillary basement membrane (RCBM) that develops in the galactose-fed rat model of diabetic ocular…”
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Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats by Hutchinson, Karen J., Gómez‐Pinilla, Fernando, Crowe, Maria J., Ying, Zhe, Basso, D. Michele

“…Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia—a painful response to normally non‐noxious stimuli. Unfortunately,…”
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Pathological CNS Autoimmune Disease Triggered by Traumatic Spinal Cord Injury: Implications for Autoimmune Vaccine Therapy by Jones, T. Bucky, Basso, D. Michele, Sodhi, Ajeet, Pan, Jonathan Z, Hart, Ronald P, MacCallum, Robert C, Lee, Sunhee, Whitacre, Caroline C, Popovich, Phillip G

“…Lymphocytes respond to myelin proteins after spinal cord injury (SCI) and may contribute to post-traumatic secondary degeneration. However, there is increasing…”
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Diabetic-like retinopathy ameliorated with the aldose reductase inhibitor WAY-121,509 by Robinson, WG, Jr, Laver, NM, Jacot, JL, Glover, JP, Basso, MD, Blouin, P, Hohman, TC

“…To evaluate the efficacy of WAY-121,509, a potent new aldose reductase inhibitor (ARI), in preventing the retinopathy that develops in the galactose-fed rat…”
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Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats by Kloos, Anne D., Fisher, Lesley C., Detloff, Megan R., Hassenzahl, David L., Basso, D. Michele

“…Spinal cord injury (SCI) causes motor and sensory deficits that impair functional performance. While more functional recovery occurs with greater white matter…”
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