Search Results - "Bassil, Christopher F."

Targeting MYCN in neuroblastoma by BET bromodomain inhibition by Puissant, Alexandre, Frumm, Stacey M, Alexe, Gabriela, Bassil, Christopher F, Qi, Jun, Chanthery, Yvan H, Nekritz, Erin A, Zeid, Rhamy, Gustafson, William Clay, Greninger, Patricia, Garnett, Matthew J, McDermott, Ultan, Benes, Cyril H, Kung, Andrew L, Weiss, William A, Bradner, James E, Stegmaier, Kimberly

“…Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to…”
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The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia by Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Zhang, Yi, Perkins, Archibald S, Shannon, Kevin, Hemann, Michael T, Puissant, Alexandre, Stegmaier, Kimberly

“…Transcriptomic and metabolic profiling reveals that the creatine kinase pathway is essential for growth of acute myeloid leukemias expressing the transcription…”
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia by Puissant, Alexandre, Fenouille, Nina, Alexe, Gabriela, Pikman, Yana, Bassil, Christopher F., Mehta, Swapnil, Du, Jinyan, Kazi, Julhash U., Luciano, Frédéric, Rönnstrand, Lars, Kung, Andrew L., Aster, Jon C., Galinsky, Ilene, Stone, Richard M., DeAngelo, Daniel J., Hemann, Michael T., Stegmaier, Kimberly

“…Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen…”
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PitViper: a software for comparative meta-analysis and annotation of functional screening data by Meslin, Paul-Arthur, Kelly, Lois M, Benbarche, Salima, Lecourt, Séverine, Lin, Kevin H, Rutter, Justine C, Bassil, Christopher F, Itzykson, Raphael, Wood, Kris C, Puissant, Alexandre, Lobry, Camille

“…Abstract Recent advancements in shRNA and Cas protein technologies have enabled functional screening methods targeting genes or non-coding regions using single…”
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Targeting MTHFD2 in acute myeloid leukemia by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M, Frumm, Stacey M, Ross, Linda, Fenouille, Nina, Bassil, Christopher F, Lewis, Caroline A, Ramos, Azucena, Gould, Joshua, Stone, Richard M, DeAngelo, Daniel J, Galinsky, Ilene, Clish, Clary B, Kung, Andrew L, Hemann, Michael T, Vander Heiden, Matthew G, Banerji, Versha, Stegmaier, Kimberly

“…Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The…”
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Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells by Ali, Moiez, Lu, Min, Ang, Hazel Xiaohui, Soderquist, Ryan S, Eyler, Christine E, Hutchinson, Haley M, Glass, Carolyn, Bassil, Christopher F, Lopez, Omar M, Kerr, D Lucas, Falcon, Christina J, Yu, Helena A, Hata, Aaron N, Blakely, Collin M, McCoach, Caroline E, Bivona, Trever G, Wood, Kris C

“…Residual cancer cells that survive drug treatments with targeted therapies act as a reservoir from which eventual resistant disease emerges. Although there is…”
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P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia by Lin, Kevin H, Rutter, Justine C, Xie, Abigail, Killarney, Shane T, Vaganay, Camille, Benaksas, Chaima, Ling, Frank, Sodaro, Gaetano, Meslin, Paul-Arthur, Bassil, Christopher F, Fenouille, Nina, Hoj, Jacob, Washart, Rachel, Ang, Hazel X, Cerda-Smith, Christian, Chaintreuil, Paul, Jacquel, Arnaud, Auberger, Patrick, Forget, Antoine, Itzykson, Raphael, Lu, Min, Lin, Jiaxing, Pierobon, Mariaelena, Sheng, Zhecheng, Li, Xinghai, Chilkoti, Ashutosh, Owzar, Kouros, Rizzieri, David A, Pardee, Timothy S, Benajiba, Lina, Petricoin, Emanuel, Puissant, Alexandre, Wood, Kris C

“…Selinexor is a first-in-class inhibitor of the nuclear exportin XPO1 that was recently approved by the US Food and Drug Administration for the treatment of…”
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Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia by Boros, Katalin, Puissant, Alexandre, Back, Morgan, Alexe, Gabriela, Bassil, Christopher F, Sinha, Papiya, Tholouli, Eleni, Stegmaier, Kimberly, Byers, Richard J, Rodig, Scott J

“…Recent discoveries have led to the testing of novel targeted therapies for the treatment of acute myeloid leukemia (AML). To better inform the results of…”
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Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation by Frumm, Stacey M., Fan, Zi Peng, Ross, Kenneth N., Duvall, Jeremy R., Gupta, Supriya, VerPlank, Lynn, Suh, Byung-Chul, Holson, Edward, Wagner, Florence F., Smith, William B., Paranal, Ronald M., Bassil, Christopher F., Qi, Jun, Roti, Giovanni, Kung, Andrew L., Bradner, James E., Tolliday, Nicola, Stegmaier, Kimberly

“…While cytotoxic chemotherapy remains the hallmark of cancer treatment, intensive regimens fall short in many malignancies, including high-risk neuroblastoma…”
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Methylation-specific PCR by Huang, Zhiqing, Bassil, Christopher F, Murphy, Susan K

“…Defining DNA methylation patterns in the genome has become essential for understanding diverse biological processes including the regulation of gene…”
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Bisulfite pyrosequencing by Bassil, Christopher F, Huang, Zhiqing, Murphy, Susan K

“…Bisulfite pyrosequencing is a sequencing-by-synthesis method used to quantitatively determine the methylation of individual CG cytosines from PCR amplicons of…”
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Bisulfite sequencing of cloned alleles by Huang, Zhiqing, Bassil, Christopher F, Murphy, Susan K

“…Bisulfite sequencing of cloned alleles is a widely used method for capturing the methylation profiles of single alleles. This method combines PCR amplification…”
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Main principles and outcomes of DNA methylation analysis by Murphy, Susan K, Bassil, Christopher F, Huang, Zhiqing

“…Epigenetic modifications, including DNA methylation, are critically important mediators of normal cell function over the course of our lives. These…”
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The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia by Vaganay, Camille, Ling, Frank, Kelly, Lois M., Ho Nhat, Duong, Forget, Antoine, Meslin, Paul-Arthur, Pasquer, Hélène, Kim, Rathana, Passet, Marie, Fodil, Sofiane, Huynh, Tony, Su, Angela H, Bassil, Christopher F, Duchmann, Matthieu, Alexe, Gabriela, Fortin, Gael, Legrand, Carine, Saadallah, Khansa, Delaney, Christopher, Pacchiardi, Kim, Kocijancic, Anja, Aziez, Lisa, Fenouille, Nina, Sebert, Marie, Ades, Lionel, Raffoux, Emmanuel, Clappier, Emmanuelle, Benajiba, Lina, Stegmaier, Kimberly, Wood, Kris C., Itzykson, Raphael, Lobry, Camille, Puissant, Alexandre

“…In Acute Myeloid Leukemia (AML), distinguishing between chemoresistance driver mechanisms and cell plasticity in response to chemotherapy is challenging due to…”
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The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies by Su, Angela, Ling, Frank, Vaganay, Camille, Pardieu, Bryann, Benajiba, Lina, Sodaro, Gaetano, Pasanisi, Justine, Lin, Kevin H, Rutter, Justine, Bassil, Christopher F., Antony-Debre, Iléana, Alexe, Gabriela, Benoist, Jean-François, Pikman, Yana, Qi, Jun, Dombret, Herve, Preudhomme, Claude, Fenouille, Nina, Golan, Hava M., Stegmaier, Kimberly, Lobry, Camille, Wood, Kris C, Itzykson, Raphael, Puissant, Alexandre

“…Metabolic rewiring of neoplastic cells engenders metabolic liabilities that can be exploited to design innovative therapeutic strategies, including those to…”
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Identification of CKMT1B As a New Target in EVI1-Positive AML by Puissant, Alexandre, Fenouille, Nina, Bassil, Christopher F., Ben-Sahra, Issam, Alexe, Gabriela, Benajiba, Lina, Ramos, Azucena, Pikman, Yana, Burgess, Michael R., Galinsky, Ilene, DeAngelo, Daniel J., Stone, Richard M., Shannon, Kevin, Hemann, Michael T., Stegmaier, Kimberly

“…Recent investigations into the relationship between cancer and cellular metabolism have revealed the strong dependency of different cancers on a diverse array…”
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Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia by Puissant, Alexandre, Fenouille, Nina, Bassil, Christopher F., Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Burgess, Michael R., Li, Qing, Luciano, Frederic, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J., Stone, Richard M., Perkins, Archibald S., Shannon, Kevin, Hemann, Michael T., Stegmaier, Kimberly

“…Abnormal expression of the transcription factor EVI1 through chromosome 3q26 rearrangements has been implicated in the development of one of the most…”
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Targeting MTHFD2 in acute myeloid leukemia by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline A., Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael T., Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly

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Targeting MTHFD2 in Acute Myeloid Leukemia by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Frumm, Stacey, Ross, Linda, Chen, Liying, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline A, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Kung, Andrew L, Vader Heiden, Matthew, Hemann, Michael T., Banerji, Versha, Stegmaier, Kimberly

“…Alterations in differentiation pathways contribute to the development of acute myeloid leukemia (AML). Differentiation therapy with all-trans retinoic acid…”
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Targeting Folate Metabolism In Acute Myelogenous Leukemia by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Frumm, Stacey M., Ross, Linda, Chen, Liying, Fenouille, Nina, Bassil, Christopher F, Clish, Clary B., Kung, Andrew L, Hemann, Michael T, Banerji, Versha, Stegmaier, Kimberly

“…There is increasing evidence that deranged metabolism is an important mechanism of cancer pathogenesis. We conducted multiple genomic analyses of publicly…”
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