Search Results - "Bassi, Rosaria"

Extracellular Sphingosine-1-Phosphate Downstream of EGFR Increases Human Glioblastoma Cell Survival by Bassi, Rosaria, Brambilla, Stefania, Tringali, Cristina, Giussani, Paola

“…Sphingosine-1-phosphate (S1P) is a crucial mediator involved in the progression of different cancers, including glioblastoma multiforme (GBM), the most…”
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Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair by Cortellino, Salvatore, Xu, Jinfei, Sannai, Mara, Moore, Robert, Caretti, Elena, Cigliano, Antonio, Le Coz, Madeleine, Devarajan, Karthik, Wessels, Andy, Soprano, Dianne, Abramowitz, Lara K., Bartolomei, Marisa S., Rambow, Florian, Bassi, Maria Rosaria, Bruno, Tiziana, Fanciulli, Maurizio, Renner, Catherine, Klein-Szanto, Andres J., Matsumoto, Yoshihiro, Kobi, Dominique, Davidson, Irwin, Alberti, Christophe, Larue, Lionel, Bellacosa, Alfonso

“…DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated…”
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Ceramide Is Involved in Temozolomide Resistance in Human Glioblastoma U87MG Overexpressing EGFR by Bassi, Rosaria, Dei Cas, Michele, Tringali, Cristina, Compostella, Federica, Paroni, Rita, Giussani, Paola

“…Glioblastoma multiforme (GBM) is the most frequent and deadly brain tumor. Many sphingolipids are crucial players in the regulation of glioma cell growth as…”
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Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection by Chiricozzi, Elena, Loberto, Nicoletta, Schiumarini, Domitilla, Samarani, Maura, Mancini, Giulia, Tamanini, Anna, Lippi, Giuseppe, Dechecchi, Maria Cristina, Bassi, Rosaria, Giussani, Paola, Aureli, Massimo

“…Sphingolipids (SLs) are amphiphilic molecules mainly associated with the external leaflet of eukaryotic plasma membrane, and are structural membrane components…”
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Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models by Cafora, Marco, Poerio, Noemi, Forti, Francesca, Loberto, Nicoletta, Pin, Davide, Bassi, Rosaria, Aureli, Massimo, Briani, Federica, Pistocchi, Anna, Fraziano, Maurizio

“…Multi drug resistant (MDR) bacteria are insensitive to the most common antibiotics currently in use. The spread of antibiotic-resistant bacteria, if not…”
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Cross‐talk between CFTR and sphingolipids in cystic fibrosis by Dobi, Dorina, Loberto, Nicoletta, Bassi, Rosaria, Pistocchi, Anna, Lunghi, Giulia, Tamanini, Anna, Aureli, Massimo

“…Cystic fibrosis (CF) is the most common inherited, life‐limiting disorder in Caucasian populations. It is caused by mutations in the gene encoding the cystic…”
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Hyaluronic Acid-Dexamethasone Nanoparticles for Local Adjunct Therapy of Lung Inflammation by Camara, Candelaria Ines, Bertocchi, Laura, Ricci, Caterina, Bassi, Rosaria, Bianchera, Annalisa, Cantu', Laura, Bettini, Ruggero, Del Favero, Elena

“…The delivery of a dexamethasone formulation directly into the lung appears as an appropriate strategy to strengthen the systemic administration, reducing the…”
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GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease by Mancini, Giulia, Loberto, Nicoletta, Olioso, Debora, Dechecchi, Maria Cristina, Cabrini, Giulio, Mauri, Laura, Bassi, Rosaria, Schiumarini, Domitilla, Chiricozzi, Elena, Lippi, Giuseppe, Pesce, Emanuela, Sonnino, Sandro, Pedemonte, Nicoletta, Tamanini, Anna, Aureli, Massimo

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most…”
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Exploring the link between ceramide and ionizing radiation by Aureli, Massimo, Murdica, Valentina, Loberto, Nicoletta, Samarani, Maura, Prinetti, Alessandro, Bassi, Rosaria, Sonnino, Sandro

“…The aim of radiotherapy is to eradicate cancer cells with ionizing radiation; tumor cell death following irradiation can be induced by several signaling…”
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Phosphatidic acid‐mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration by Shiozaki, Kazuhiro, Takahashi, Kohta, Hosono, Masahiro, Yamaguchi, Kazunori, Hata, Keiko, Shiozaki, Momo, Bassi, Rosaria, Prinetti, Alessandro, Sonnino, Sandro, Nitta, Kazuo, Miyagi, Taeko

“…ABSTRACT The plasma membrane‐associated sialidase NEU3 plays crucial roles in regulation of transmembrane signaling, and its aberrant up‐regulation in various…”
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β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration by Lunghi, Giulia, Carsana, Emma Veronica, Loberto, Nicoletta, Cioccarelli, Laura, Prioni, Simona, Mauri, Laura, Bassi, Rosaria, Duga, Stefano, Straniero, Letizia, Asselta, Rosanna, Soldà, Giulia, Di Fonzo, Alessio, Frattini, Emanuele, Magni, Manuela, Liessi, Nara, Armirotti, Andrea, Ferrari, Elena, Samarani, Maura, Aureli, Massimo

“…β-glucocerebrosidase is a lysosomal hydrolase involved in the catabolism of the sphingolipid glucosylceramide. Biallelic loss of function mutations in this…”
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Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells by Tamanini, Anna, Lippi, Giuseppe, Dechecchi, Maria Cristina, Sonnino, Sandro, Aureli, Massimo, Munari, Silvia, Samarani, Maura, Chiricozzi, Elena, Giussani, Paola, Bassi, Rosaria, Mancini, Giulia, Loberto, Nicoletta, Schiumarini, Domitilla, Cabrini, Giulio

“…Cystic fibrosis (CF) is the most common autosomal genetic recessive disease caused by mutations of gene encoding for the cystic fibrosis transmembrane…”
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HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration by Bassi, Rosaria, Giussani, Paola, Anelli, Viviana, Colleoni, Thomas, Pedrazzi, Marco, Patrone, Mauro, Viani, Paola, Sparatore, Bianca, Melloni, Edon, Riboni, Laura

“…HMGB1 (high mobility group box 1 protein) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation and migration,…”
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GBA2-encoded β-glucosidase activity is involved in the inflammatory response to Pseudomonas aeruginosa by Loberto, Nicoletta, Tebon, Maela, Lampronti, Ilaria, Marchetti, Nicola, Aureli, Massimo, Bassi, Rosaria, Giri, Maria Grazia, Bezzerri, Valentino, Lovato, Valentina, Cantù, Cinzia, Munari, Silvia, Cheng, Seng H, Cavazzini, Alberto, Gambari, Roberto, Sonnino, Sandro, Cabrini, Giulio, Dechecchi, Maria Cristina

“…Current anti-inflammatory strategies for the treatment of pulmonary disease in cystic fibrosis (CF) are limited; thus, there is continued interest in…”
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Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts by Aureli, Massimo, Bassi, Rosaria, Loberto, Nicoletta, Regis, Stefano, Prinetti, Alessandro, Chigorno, Vanna, Aerts, Johannes M., Boot, Rolf G., Filocamo, Mirella, Sonnino, Sandro

“…Gaucher disease (GD) is the most common lysosomal disorder and is caused by an inherited autosomal recessive deficiency in β-glucocerebrosidase. This enzyme,…”
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Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA by Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, Julian, Bassi, Maria Rosaria, Quintana, Maria Del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Yong, Gourdon, Pontus, Ofori, Michael Fokuo, Christensen, Sebastian Boje, Minja, Daniel Thomas Remias, Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas, Wang, Kaituo

“…Malaria during pregnancy is a major global health problem caused by infection with Plasmodium falciparum parasites. Severe effects arise from the accumulation…”
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Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content by Aureli, Massimo, Bassi, Rosaria, Prinetti, Alessandro, Chiricozzi, Elena, Pappalardi, Brigida, Chigorno, Vanna, Di Muzio, Nadia, Loberto, Nicoletta, Sonnino, Sandro

“…We detected significant levels of β-glucosidase, β-galactosidase, sialidase Neu3 and sphingomyelinase activities associated with the plasma membrane of…”
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Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers by Nazerai, Loulieta, Schøller, Amalie Skak, Bassi, Maria Rosaria, Buus, Søren, Stryhn, Anette, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup

“…Zika virus (ZIKV), a mosquito-borne flavivirus, came into the spotlight in 2016 when it was found to be associated with an increased rate of microcephalic…”
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A Systematic, Unbiased Mapping of CD8 + and CD4 + T Cell Epitopes in Yellow Fever Vaccinees by Stryhn, Anette, Kongsgaard, Michael, Rasmussen, Michael, Harndahl, Mikkel Nors, Østerbye, Thomas, Bassi, Maria Rosaria, Thybo, Søren, Gabriel, Mette, Hansen, Morten Bagge, Nielsen, Morten, Christensen, Jan Pravsgaard, Randrup Thomsen, Allan, Buus, Soren

“…Examining CD8 and CD4 T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8…”
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Phosphatidylinositol 3-Kinase/AKT Pathway Regulates the Endoplasmic Reticulum to Golgi Traffic of Ceramide in Glioma Cells by Giussani, Paola, Brioschi, Loredana, Bassi, Rosaria, Riboni, Laura, Viani, Paola

“…Different lines of evidence indicate that both aberrant activation of the phosphatidylinositol 3-OH kinase (PI3K)/Akt survival pathway and down-regulation of…”
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