Search Results - "Bassett, Emily A"
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HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
Published in The Journal of cell biology (25-07-2011)“…Centromeres of higher eukaryotes are epigenetically marked by the centromere-specific CENP-A nucleosome. New CENP-A recruitment requires the CENP-A histone…”
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Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP
Published in Cell (01-05-2009)“…The centromere is responsible for accurate chromosome segregation. Mammalian centromeres are specified epigenetically, with all active centromeres containing…”
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HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly
Published in Developmental cell (17-04-2012)“…Centromeres are defined by the presence of chromatin containing the histone H3 variant, CENP-A, whose assembly into nucleosomes requires the chromatin assembly…”
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The histone variant CENP-A and centromere specification
Published in Current opinion in cell biology (01-02-2008)“…The centromere is the chromosomal locus that guides faithful inheritance. Centromeres are specified epigenetically, and the histone H3 variant CENP-A has…”
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Both tails and the centromere targeting domain of CENP-A are required for centromere establishment
Published in The Journal of cell biology (02-03-2015)“…The centromere-defined by the presence of nucleosomes containing the histone H3 variant, CENP-A-is the chromosomal locus required for the accurate segregation…”
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Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors
Published in The Journal of cell biology (26-07-2010)“…The nearly ubiquitous presence of repetitive centromere DNA sequences across eukaryotic species is in paradoxical contrast to their apparent functional…”
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Structural and Functional Basis for Therapeutic Modulation of p53 Signaling
Published in Clinical cancer research (15-10-2008)“…Effective modulation of structural features and/or functional properties of the major tumor suppressor p53 as a wild-type or cancer-associated mutant protein…”
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The structure of (CENP-A-H4) 2 reveals physical features that mark centromeres
Published in Nature (London) (16-09-2010)“…Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3…”
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Abstract 520: The role of the calpain pathway in early response and acquired resistance to radiation in glioblastoma
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Glioblastoma (GBM) is the most aggressive, malignant brain tumor that is highly heterogeneous and often develops resistance to conventional chemotherapy and…”
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Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma
Published in Oncotarget (06-03-2018)“…Glioblastoma (GBM) is an aggressive, malignant brain tumor that inevitably develops resistance to conventional chemotherapy and radiation treatments. In order…”
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Abstract 4755: Calpastatin phosphorylation regulates radiation response in glioblastoma
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumor in adults. Patients diagnosed with GBM have a very poor prognosis and…”
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The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres
Published in Nature (London) (16-09-2010)“…Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3…”
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The structure of (CENP-A-H4)^sub 2^ reveals physical features that mark centromeres
Published in Nature (London) (16-09-2010)“…Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3…”
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The structure of (CENP-A-H4) sub(2) reveals physical features that mark centromeres
Published in Nature (London) (06-09-2010)“…Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3…”
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