Search Results - "Bassett, Emily"

The structure of (CENP-A-H4) 2 reveals physical features that mark centromeres by Black, Ben E, Sekulic, Nikolina, Bassett, Emily A, Rogers, Danielle J

“…Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3…”
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Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function by Singh, Rajbir, Bassett, Emily, Chakravarti, Arnab, Parthun, Mark R

“…Abstract Replication-dependent histones are expressed in a cell cycle regulated manner and supply the histones necessary to support DNA replication. In…”
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HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore by Barnhart, Meghan C, Kuich, P Henning J L, Stellfox, Madison E, Ward, Jared A, Bassett, Emily A, Black, Ben E, Foltz, Daniel R

“…Centromeres of higher eukaryotes are epigenetically marked by the centromere-specific CENP-A nucleosome. New CENP-A recruitment requires the CENP-A histone…”
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HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly by Bassett, Emily A., DeNizio, Jamie, Barnhart-Dailey, Meghan C., Panchenko, Tanya, Sekulic, Nikolina, Rogers, Danielle J., Foltz, Daniel R., Black, Ben E.

“…Centromeres are defined by the presence of chromatin containing the histone H3 variant, CENP-A, whose assembly into nucleosomes requires the chromatin assembly…”
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Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP by Foltz, Daniel R., Jansen, Lars E.T., Bailey, Aaron O., Yates, John R., Bassett, Emily A., Wood, Stacey, Black, Ben E., Cleveland, Don W.

“…The centromere is responsible for accurate chromosome segregation. Mammalian centromeres are specified epigenetically, with all active centromeres containing…”
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The histone variant CENP-A and centromere specification by Black, Ben E, Bassett, Emily A

“…The centromere is the chromosomal locus that guides faithful inheritance. Centromeres are specified epigenetically, and the histone H3 variant CENP-A has…”
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Both tails and the centromere targeting domain of CENP-A are required for centromere establishment by Logsdon, Glennis A, Barrey, Evelyne J, Bassett, Emily A, DeNizio, Jamie E, Guo, Lucie Y, Panchenko, Tanya, Dawicki-McKenna, Jennine M, Heun, Patrick, Black, Ben E

“…The centromere-defined by the presence of nucleosomes containing the histone H3 variant, CENP-A-is the chromosomal locus required for the accurate segregation…”
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Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses by Bassett, Emily, Gjekmarkaj, Eva, Mason, Amy M., Zhao, Sizheng Steven, Burgess, Stephen

“…Vitamin D deficiency has been linked to various chronic pain conditions. However, randomized trials of vitamin D supplementation have had mixed results. In…”
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Abstract 520: The role of the calpain pathway in early response and acquired resistance to radiation in glioblastoma by Bassett, Emily A., Chakravarti, Arnab

“…Glioblastoma (GBM) is the most aggressive, malignant brain tumor that is highly heterogeneous and often develops resistance to conventional chemotherapy and…”
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Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation by Palanichamy, Kamalakannan, Thirumoorthy, Krishnan, Kanji, Suman, Gordon, Nicolaus, Singh, Rajbir, Jacob, John R, Sebastian, Nikhil, Litzenberg, Kevin T, Patel, Disha, Bassett, Emily, Ramasubramanian, Brinda, Lautenschlaeger, Tim, Fischer, Steven M, Ray-Chaudhury, Abhik, Chakravarti, Arnab

“…We employed a metabolomics-based approach with the goal to better understand the molecular signatures of glioblastoma cells and tissues, with an aim toward…”
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Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors by Bassett, Emily A, Wood, Stacey, Salimian, Kevan J, Ajith, Sandya, Foltz, Daniel R, Black, Ben E

“…The nearly ubiquitous presence of repetitive centromere DNA sequences across eukaryotic species is in paradoxical contrast to their apparent functional…”
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Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma by Bassett, Emily A, Palanichamy, Kamalakannan, Pearson, Mitchell, McElroy, Joseph P, Haque, Saikh Jaharul, Bell, Erica Hlavin, Chakravarti, Arnab

“…Glioblastoma (GBM) is an aggressive, malignant brain tumor that inevitably develops resistance to conventional chemotherapy and radiation treatments. In order…”
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Structural and Functional Basis for Therapeutic Modulation of p53 Signaling by BASSETT, Emily A, WENGE WANG, RASTINEJAD, Farzan, EL-DEIRY, Wafik S

“…Effective modulation of structural features and/or functional properties of the major tumor suppressor p53 as a wild-type or cancer-associated mutant protein…”
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Inconsistency in UK Biobank Event Definitions From Different Data Sources and Its Impact on Bias and Generalizability: A Case Study of Venous Thromboembolism by Bassett, Emily, Broadbent, James, Gill, Dipender, Burgess, Stephen, Mason, Amy M

“…Abstract The UK Biobank study contains several sources of diagnostic data, including hospital inpatient data and data on self-reported conditions for…”
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Abstract 3318: Phosphoproteomic profiling of glioblastoma stem cells to uncover mechanisms of radiation resistance by Bassett, Emily, Palanichamy, Kamalakannan, Chakravarti, Arnab

“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. GBM tumors universally develop resistance to chemotherapy and…”
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Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function by Singh, Rajbir, Bassett, Emily, Chakravarti, Arnab, Parthun, Mark R

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Abstract 4755: Calpastatin phosphorylation regulates radiation response in glioblastoma by Bassett, Emily A., Pearson, Mitchell, Palanichamy, Kamalakannan, Haque, Saikh J., Chakravarti, Arnab

“…Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumor in adults. Patients diagnosed with GBM have a very poor prognosis and…”
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RBIO-02. CALPASTATIN PHOSPHORYLATION REGULATES RADIATION RESPONSE IN GLIOBLASTOMA by Bassett, Emily, Palanichamy, Kamalakannan, Pearson, Mitchell, Haque, S Jaharul, Chakravarti, Arnab

“…Glioblastoma (GBM) is an aggressive, malignant brain tumor that often develops resistance to conventional chemotherapy and radiation treatments. In order to…”
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Corrigenda: Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function by Singh, Rajbir, Bassett, Emily, Chakravarti, Arnab, Parthun, Mark R

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Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas by Beyer, Sasha J, Bell, Erica H, McElroy, Joseph P, Fleming, Jessica L, Cui, Tiantian, Becker, Aline, Bassett, Emily, Johnson, Benjamin, Gulati, Pooja, Popp, Ilinca, Staszewski, Ori, Prinz, Marco, Grosu, Anca L, Haque, Saikh Jaharul, Chakravarti, Arnab

“…The presence of an ( ) mutation in gliomas is associated with favorable outcomes compared to gliomas without the mutation ( wild-type, WT). The underlying…”
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