Search Results - "Bassermann, Florian"

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer by Bassermann, Florian, Eichner, Ruth, Pagano, Michele

“…Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the timely and precise ubiquitin-proteasome-dependent degradation of…”
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Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling by Zecha, Jana, Gabriel, Wassim, Spallek, Ria, Chang, Yun-Chien, Mergner, Julia, Wilhelm, Mathias, Bassermann, Florian, Kuster, Bernhard

“…Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ…”
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The Technical University of Munich Cancer Center - elevating cancer treatment through science by Hecker, Judith S, Algül, Hana, Illert, Anna L, Bassermann, Florian

“…Keywords: TUM Cancer Center, CRC/TRR 387 - UbiQancer, TranslaTUM, Immunotherapy Program TUM, Personalized Oncology TUM, ECTU TUM, CHIP Clinic TUM,…”
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Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression by Weickert, Marie-Theresa, Hecker, Judith S., Buck, Michèle C., Schreck, Christina, Rivière, Jennifer, Schiemann, Matthias, Schallmoser, Katharina, Bassermann, Florian, Strunk, Dirk, Oostendorp, Robert A. J., Götze, Katharina S.

“…Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal hematopoietic stem cell disorders with a poor prognosis, especially for elderly…”
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The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint by Bassermann, Florian, Frescas, David, Guardavaccaro, Daniele, Busino, Luca, Peschiaroli, Angelo, Pagano, Michele

“…In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show that, in response to genotoxic…”
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Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival by Dietachmayr, Michael, Rathakrishnan, Abirami, Karpiuk, Oleksandra, von Zweydorf, Felix, Engleitner, Thomas, Fernández-Sáiz, Vanesa, Schenk, Petra, Ueffing, Marius, Rad, Roland, Eilers, Martin, Gloeckner, Christian Johannes, Clemm von Hohenberg, Katharina, Bassermann, Florian

“…Regulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In…”
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Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity by Eichner, Ruth, Heider, Michael, Fernández-Sáiz, Vanesa, van Bebber, Frauke, Garz, Anne-Kathrin, Lemeer, Simone, Rudelius, Martina, Targosz, Bianca-Sabrina, Jacobs, Laura, Knorn, Anna-Maria, Slawska, Jolanta, Platzbecker, Uwe, Germing, Ulrich, Langer, Christian, Knop, Stefan, Einsele, Herrmann, Peschel, Christian, Haass, Christian, Keller, Ulrich, Schmid, Bettina, Götze, Katharina S, Kuster, Bernhard, Bassermann, Florian

“…Thalidomide and its derivatives lenalidomide and pomalidomide, which are used to treat multiple myeloma and del(5q) myelodysplastic syndrome, have antitumor…”
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Clinical characteristics and outcome of multiple myeloma patients with concomitant COVID-19 at Comprehensive Cancer Centers in Germany by Engelhardt, Monika, Shoumariyeh, Khalid, Rösner, Amelie, Ihorst, Gabriele, Biavasco, Francesca, Meckel, Katharina, von Metzler, Ivana, Treurich, Sebastian, Hebart, Holger, Grube, Matthias, Kull, Miriam, Bassermann, Florian, Schäfer-Eckart, Kerstin, Hoferer, Anette, Einsele, Hermann, Rasche, Leo, Wäsch, Ralph

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MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF by Wang, Xin, Ros, Uris, Agrawal, Deepti, Keller, Eva C., Slotta-Huspenina, Julia, Dill, Veronika, Shen, Bo, Shi, Run, Herold, Tobias, Belka, Claus, Mishra, Ritu, Bassermann, Florian, Garcia-Saez, Ana J., Jost, Philipp J.

“…The blockade of cellular differentiation represents a hallmark of acute myeloid leukemia (AML), which is largely attributed to the dysfunction of…”
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Prognostic Implications of the Seventh Edition of the International Union Against Cancer Classification for Patients With Gastric Cancer: The Western Experience of Patients Treated in a Single-Center European Institution by REIM, Daniel, LOOS, Martin, FRIESS, Helmut, SCHUHMACHER, Christoph, VOGL, Fabian, NOVOTNY, Alexander, SCHUSTER, Tibor, LANGER, Rupert, BECKER, Karen, HÖFLER, Heinz, SIVEKE, Jens, BASSERMANN, Florian

“…Validity of the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) staging systems for gastric cancer has…”
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MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically by Munkhbaatar, Enkhtsetseg, Dietzen, Michelle, Agrawal, Deepti, Anton, Martina, Jesinghaus, Moritz, Boxberg, Melanie, Pfarr, Nicole, Bidola, Pidassa, Uhrig, Sebastian, Höckendorf, Ulrike, Meinhardt, Anna-Lena, Wahida, Adam, Heid, Irina, Braren, Rickmer, Mishra, Ritu, Warth, Arne, Muley, Thomas, Poh, Patrina S. P., Wang, Xin, Fröhling, Stefan, Steiger, Katja, Slotta-Huspenina, Julia, van Griensven, Martijn, Pfeiffer, Franz, Lange, Sebastian, Rad, Roland, Spella, Magda, Stathopoulos, Georgios T., Ruland, Jürgen, Bassermann, Florian, Weichert, Wilko, Strasser, Andreas, Branca, Caterina, Heikenwalder, Mathias, Swanton, Charles, McGranahan, Nicholas, Jost, Philipp J.

“…Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer…”
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Conditioning with fludarabine and treosulfan compared to FLAMSA-RIC in allogeneic stem cell transplantation for myeloid malignancies: a retrospective single-center analysis by Braitsch, Krischan, Schwarz, Alix, Koch, Katrin, Hubbuch, Mara, Menzel, Helge, Keller, Ulrich, Götze, Katharina S., Bassermann, Florian, Herhaus, Peter, Verbeek, Mareike

“…Reduced intensity conditioning (RIC) and reduced toxicity conditioning (RTC) regimens enable allogeneic hematopoietic stem cell transplantation (alloSCT) to…”
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Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300 by Hettler, Franziska, Schreck, Christina, Marquez, Sandra Romero, Engleitner, Thomas, Vilne, Baiba, Landspersky, Theresa, Weidner, Heike, Hausinger, Renate, Mishra, Ritu, Oellinger, Rupert, Rauner, Martina, Naumann, Ronald, Peschel, Christian, Bassermann, Florian, Rad, Roland, Istvanffy, Rouzanna, Oostendorp, Robert A J

“…Remodeling of the bone marrow microenvironment in chronic inflammation and in aging reduces hematopoietic stem cell (HSC) function. To assess the mechanisms of…”
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Initial evaluation of [18F]-FACBC for PET imaging of multiple myeloma by Morath, Volker, Heider, Michael, Mittelhäuser, Markus, Rolbieski, Hannes, Stroh, Jacob, Calais, Jérémie, Eiber, Matthias, Bassermann, Florian, Weber, Wolfgang A.

“…Rationale Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM…”
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Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response by Zhang, Le, Wirth, Matthias, Patra, Upayan, Stroh, Jacob, Isaakidis, Konstandina, Rieger, Leonie, Kossatz, Susanne, Milanovic, Maja, Zang, Chuanbing, Demel, Uta, Keiten‐Schmitz, Jan, Wagner, Kristina, Steiger, Katja, Rad, Roland, Bassermann, Florian, Müller, Stefan, Keller, Ulrich, Schick, Markus

“…The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a…”
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SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma by Fernández-Sáiz, Vanesa, Targosz, Bianca-Sabrina, Lemeer, Simone, Eichner, Ruth, Langer, Christian, Bullinger, Lars, Reiter, Clemens, Slotta-Huspenina, Julia, Schroeder, Sonja, Knorn, Anna-Maria, Kurutz, Julia, Peschel, Christian, Pagano, Michele, Kuster, Bernhard, Bassermann, Florian

“…The Tel2 (also known as Telo2) and Tti1 proteins control the cellular abundance of mammalian PIKKs and are integral components of mTORC1 and mTORC2. Here we…”
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Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia by Dill, Veronika, Kirmes, Kilian, Han, Jiaying, Klug, Melissa, Rosenbaum, Marc, Viggiani, Giacomo, von Scheidt, Moritz, List, Markus, Herhaus, Peter, Ruland, Jürgen, Bassermann, Florian, Laugwitz, Karl-Ludwig, Götze, Katharina S, Jost, Philipp J, Jilg, Stefanie, Bloxham, Conor J, Raake, Philip W J, Bernlochner, Isabell, Bongiovanni, Dario

“…Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased…”
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Comparative analysis of extracellular vesicle isolation methods from human AML bone marrow cells and AML cell lines by Lang, Jonas B., Buck, Michèle C., Rivière, Jennifer, Stambouli, Oumaima, Sachenbacher, Ken, Choudhary, Purva, Dietz, Hendrik, Giebel, Bernd, Bassermann, Florian, Oostendorp, Robert A. J., Götze, Katharina S., Hecker, Judith S.

“…Cellular crosstalk between hematopoietic stem/progenitor cells and the bone marrow (BM) niche is vital for the development and maintenance of myeloid…”
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Comprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies by Odinius, Timo O., Buschhorn, Lars, Wagner, Celina, Hauch, Richard T., Dill, Veronika, Dechant, Marta, Buck, Michele C., Shoumariyeh, Khalid, Moog, Philipp, Schwaab, Juliana, Reiter, Andreas, Brockow, Knut, Götze, Katharina, Bassermann, Florian, Höckendorf, Ulrike, Branca, Caterina, Jost, Philipp J., Jilg, Stefanie

“…Purpose Hypereosinophilia represents a heterogenous group of severe medical conditions characterized by elevated numbers of eosinophil granulocytes in…”
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Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells by Romero Marquez, Sandra, Hettler, Franziska, Hausinger, Renate, Schreck, Christina, Landspersky, Theresa, Henkel, Lynette, Angerpointner, Corinne, Demir, Ihsan E, Schiemann, Matthias, Bassermann, Florian, Götze, Katharina S, Istvánffy, Rouzanna, Oostendorp, Robert A J

“…Hematopoietic stem cell self-renewal, proliferation, and differentiation are independently regulated by intrinsic as well as extrinsic mechanisms. We…”
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