Search Results - "Basse, Per"

Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells by Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H, Wang, Eunice S, Segal, Brahm H, Baysal, Bora E

“…Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to…”
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Zinc in innate and adaptive tumor immunity by John, Erica, Laskow, Thomas C, Buchser, William J, Pitt, Bruce R, Basse, Per H, Butterfield, Lisa H, Kalinski, Pawel, Lotze, Michael T

“…Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development…”
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NK cells in the tumor microenvironment by Larsen, Stine K, Gao, Yanhua, Basse, Per H

“…The presence of natural killer (NK) cells in the tumor microenvironment correlates with outcome in a variety of cancers. However, the role of intratumoral NK…”
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Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes by Gomez-Casal, Roberto, Bhattacharya, Chitralekha, Ganesh, Nandita, Bailey, Lisa, Basse, Per, Gibson, Michael, Epperly, Michael, Levina, Vera

“…Ionizing radiation (IR) is used for patients diagnosed with unresectable non small cell lung cancer (NSCLC), however radiotherapy remains largely palliative…”
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NFκB-Activated COX2/PGE2/EP4 Axis Controls the Magnitude and Selectivity of BCG-Induced Inflammation in Human Bladder Cancer Tissues by Ibrahim, Omar M., Basse, Per H., Jiang, Weijian, Guru, Khurshid, Chatta, Gurkamal, Kalinski, Pawel

“…Bacillus Calmette-Guérin (BCG) is commonly used in the immunotherapy of bladder cancer (BlCa) but its effectiveness is limited to only a fraction of patients…”
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Cancer Stem Cells Protect Non-Stem Cells From Anoikis: Bystander Effects by Kim, Seog-Young, Hong, Se-Hoon, Basse, Per H., Wu, Chuanyue, Bartlett, David L., Kwon, Yong Tae, Lee, Yong J.

“…ABSTRACT Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between…”
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Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment by Theodoraki, Marie-Nicole, Yerneni, Saigopalakrishna, Sarkar, Saumendra N, Orr, Brian, Muthuswamy, Ravikumar, Voyten, Jamie, Modugno, Francesmary, Jiang, Weijian, Grimm, Melissa, Basse, Per H, Bartlett, David L, Edwards, Robert P, Kalinski, Pawel

“…Presence of cytotoxic CD8 T cells (CTL) in tumor microenvironments (TME) is critical for the effectiveness of immune therapies and patients' outcome, whereas…”
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Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates by Zimmerlin, Ludovic, Donnenberg, Albert D, Rubin, J Peter, Basse, Per, Landreneau, Rodney J, Donnenberg, Vera S

“…Adipose-derived stem cells (ASCs) have been proposed to stabilize autologous fat grafts for regenerative therapy, but their safety is unknown in the setting of…”
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus by Jørgensen, Astrid Sissel, Brandum, Emma Probst, Mikkelsen, Jeppe Malthe, Orfin, Klaudia A., Boilesen, Ditte Rahbæk, Egerod, Kristoffer Lihme, Moussouras, Natasha A., Vilhardt, Frederik, Kalinski, Pawel, Basse, Per, Chen, Yen-Hsi, Yang, Zhang, Dwinell, Michael B., Volkman, Brian F., Veldkamp, Christopher T., Holst, Peter Johannes, Lahl, Katharina, Goth, Christoffer Knak, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene

“…The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant…”
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Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression by XIAOYAN LIANG, DE VERA, Michael E, LOTZE, Michael T, BUCHSER, William J, DE VIVAR CHAVEZ, Antonio Romo, LOUGHRAN, Patricia, STOLZ, Donna Beer, BASSE, Per, TAO WANG, VAN HOUTEN, Bennett, ZEH, Herbert J

“…Administration of high-dose interleukin-2 (HDIL-2) has durable antitumor effects in 5% to 10% of patients with melanoma and renal cell carcinoma. However,…”
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Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate by Liu, June, Pascal, Laura E, Isharwal, Sudhir, Metzger, Daniel, Ramos Garcia, Raquel, Pilch, Jan, Kasper, Susan, Williams, Karin, Basse, Per H, Nelson, Joel B, Chambon, Pierre, Wang, Zhou

“…Determining the source of regenerated luminal epithelial cells in the adult prostate during androgen deprivation and replacement will provide insights into the…”
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Adoptive transfer of natural killer cells promotes the anti-tumor efficacy of T cells by Goding, Stephen R, Yu, Shaohong, Bailey, Lisa M, Lotze, Michael T, Basse, Per H

“…Abstract The density of NK cells in tumors correlates positively with prognosis in many types of cancers. The average number of infiltrating NK cells is,…”
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Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the Nucleus by Liu, Xi, Hein, Jennifer, Richardson, Simon C.W., Basse, Per H., Toptan, Tuna, Moore, Patrick S., Gjoerup, Ole V., Chang, Yuan

“…Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and…”
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Therapeutic Anti-Tumor Efficacy of DC-Based Vaccines Targeting TME-Associated Antigens Is Improved When Combined with a Chemokine-Modulating Regimen and/or Anti-PD-L1 by Taylor, Jennifer L, Kokolus, Kathleen M, Basse, Per H, Filderman, Jessica N, Cosgrove, Chloe E, Watkins, Simon C, Gambotto, Andrea, Lowe, Devin B, Edwards, Robert P, Kalinski, Pawel, Storkus, Walter J

“…We previously reported that dendritic cell (DC)-based vaccines targeting antigens expressed by tumor-associated vascular endothelial cells (VECs) and pericytes…”
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Viral infection of implanted meningeal tumors induces antitumor memory T-cells to travel to the brain and eliminate established tumors by Gao, Yanhua, Whitaker-Dowling, Patricia, Barmada, Mamdouha A, Basse, Per H, Bergman, Ira

“…Leptomeningeal metastases occur in 2%-5% of patients with breast cancer and have an exceptionally poor prognosis. The blood-brain and blood-meningeal barriers…”
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Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin by Gurski, Lisa A, Knowles, Lynn M, Basse, Per H, Maranchie, Jodi K, Watkins, Simon C, Pilch, Jan

“…Chloride intracellular channel 1 (CLIC1) has been shown to be upregulated in various malignancies but its exact function remains unclear. Here, it is revealed…”
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Novel Nuclear Localization of Fatty Acid Synthase Correlates with Prostate Cancer Aggressiveness by Madigan, Allison A, Rycyna, Kevin J, Parwani, Anil V, Datiri, Yeipyeng J, Basudan, Ahmed M, Sobek, Kathryn M, Cummings, Jessica L, Basse, Per H, Bacich, Dean J, O'Keefe, Denise S

“…Fatty acid synthase is up-regulated in a variety of cancers, including prostate cancer. Up-regulation of fatty acid synthase not only increases production of…”
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61892 Systemic TLR3-targeting Combinatorial Chemokine Modulation Sensitizes Murine Tumors to PD-1 Blockade by Kokolus, Kathleen M., Obermajer, Nataša, Basse, Per, Kalinski, Pawel

“…ABSTRACT IMPACT: This work will lead to improved efficacy of immunotherapy directly impacting the survival of patients with hard to treat cancers…”
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Exogenous activated NK cells enhance trafficking of endogenous NK cells to endometriotic lesions by Montenegro, Mary Lourdes, Ferriani, Rui Alberto, Basse, Per H

“…Endometriosis is defined as the presence of endometrial glands and stroma at ectopic locations. Although the prevalence of endometriosis is as high as 35%-50%,…”
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Matrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation by Edsparr, Karin, Basse, Per H., Goldfarb, Ronald H., Albertsson, Per

“…To efficiently combat solid tumours, endogenously or adoptively transferred cytotoxic T cells and natural killer (NK) cells, need to leave the vasculature,…”
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