Search Results - "Bass, Jonathan Y."

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064 by Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

“…Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR…”
Get full text

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene by Bass, Jonathan Y., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Mills, Wendy Y., Navas, Frank, Parks, Derek J., Smalley, Terrence L., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

“…To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR…”
Get full text

Single-Molecule Imaging of Platinum Ligand Exchange Reaction Reveals Reactivity Distribution by Esfandiari, N. Melody, Wang, Yong, Bass, Jonathan Y, Cornell, Trevor P, Otte, Douglas A. L, Cheng, Ming H, Hemminger, John C, McIntire, Theresa M, Mandelshtam, Vladimir A, Blum, Suzanne A

“…Single-molecule fluorescence microscopy provided information about the real-time distribution of chemical reactivity on silicon oxide supports at the…”
Get full text

FXR agonist activity of conformationally constrained analogs of GW 4064 by Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.

“…Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either…”
Get full text

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064 by Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

“…Starting from the known FXR agonist GW 4064 1a, a series of alternately 3,5-substituted isoxazoles was prepared. Several of these analogs were potent full FXR…”
Get full text

Toward the Single-Molecule Investigation of Organometallic Reaction Mechanisms: Single-Molecule Imaging of Fluorophore-Tagged Palladium(II) Complexes by Canham, Stephen M, Bass, Jonathan Y, Navarro, Oscar, Lim, Sung-Gon, Das, Neeladri, Blum, Suzanne A

“…The single-molecule fluorescence microscopy imaging of individual palladium(II) complexes is reported and the requisite high-quantum-yield BODIPY fluorophore…”
Get full text

Deconvoluting Subensemble Chemical Reaction Kinetics of Platinum–Sulfur Ligand Exchange Detected with Single-Molecule Fluorescence Microscopy by Esfandiari, N. Melody, Wang, Yong, Bass, Jonathan Y, Blum, Suzanne A

“…The subensemble kinetics of a platinum–sulfur covalent chemical reaction at the solution/surface interface of a model industrial catalyst support was examined…”
Get full text