Search Results - "Bass, Alan"

Evaluation of drug‐induced QT interval prolongation in animal and human studies: a literature review of concordance by Vargas, Hugo M, Bass, Alan S, Koerner, John, Matis‐Mitchell, Sherri, Pugsley, Michael K, Skinner, Matthew, Burnham, Matthew, Bridgland‐Taylor, Matthew, Pettit, Syril, Valentin, Jean‐Pierre

“…Evaluating whether a new medication prolongs QT intervals is a critical safety activity that is conducted in a sensitive animal model during non‐clinical drug…”
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Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry by Bass, Alan S., Pugsley, Michael K., Sannajust, Frederick, Yoshinaga, Takashi, Valentin, Jean-Pierre

“…This commentary highlights and expands upon the thoughts conveyed in the lecture by Dr. Alan S. Bass, recipient of the 2017 Distinguished Service Award from…”
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Is there a role for the no observed adverse effect level in safety pharmacology? by Mow, Tomas, Andersen, Ninette K., Dragsted, Nils, Lassen, Anders B., Laursen, Morten, Bass, Alan S., Valentin, Jean-Pierre, Markgraf, Carrie, Authier, Simon, Baird, Theodore J., Bhatt, Siddhartha, Traebert, Martin, Leishman, Derek J., Jones, David, Curtis, Michael J.

“…In nonclinical toxicology the highest dose or exposure without test article-related adverse effects, known as the No Observed Adverse Effect Level (NOAEL), is…”
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A Historical View and Vision into the Future of the Field of Safety Pharmacology by Bass, Alan S, Hombo, Toshiyasu, Kasai, Chieko, Kinter, Lewis B, Valentin, Jean-Pierre

“…Professor Gerhard Zbinden recognized in the 1970s that the standards of the day for testing new candidate drugs in preclinical toxicity studies failed to…”
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ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation by Hanson, Laurie A., Bass, Alan S., Gintant, Gary, Mittelstadt, Scott, Rampe, David, Thomas, Karluss

“…Drugs that delay cardiac repolarization pose potential safety risks to patients and cause serious regulatory concern because of the link between QT interval…”
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Benchmarking Safety Pharmacology regulatory packages and best practice by Lindgren, Silvana, Bass, Alan S., Briscoe, Richard, Bruse, Kristy, Friedrichs, Gregory S., Kallman, Mary Jeanne, Markgraf, Carrie, Patmore, Leslie, Pugsley, Michael K.

“…The objectives of this survey were to obtain a global information update regarding current industry perspectives that describe Safety Pharmacology programs as…”
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Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics by Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander R., Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishman, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre

“…Biological therapeutic agents (biologicals), such as monoclonal antibodies (mAbs), are increasingly important in the treatment of human disease, and many types…”
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Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1) by Deng, Yongqi, Yang, Zhiwei, Shipps, Gerald W., Lo, Sie-Mun, West, Robert, Hwa, Joyce, Zheng, Shuqin, Farley, Constance, Lachowicz, Jean, van Heek, Margaret, Bass, Alan S., Sinha, Dinesh P., Mahon, Craig R., Cartwright, Mark E.

“…4,5-Dihydro-3H-spiro[benzo[b][1,4]oxazepine-2,4′-piperidine derivatives were identified as SCD1 inhibitors from high throughput screening. Optimization of this…”
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Exploratory drug safety: A discovery strategy to reduce attrition in development by Bass, Alan S., Cartwright, Mark E., Mahon, Craig, Morrison, Richard, Snyder, Ronald, McNamara, Paul, Bradley, Prudence, Zhou, Ying-Ying, Hunter, John

“…Identification of novel new molecules which hold the greatest promise of safe and effective therapies remains a continuous challenge to the pharmaceutical…”
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Pharmacological differences between beta-blockers and postoperative mortality following colon cancer surgery by Ekestubbe, Lovisa, Bass, Gary Alan, Forssten, Maximilian Peter, Sjölin, Gabriel, Cao, Yang, Matthiessen, Peter, Ahl Hulme, Rebecka, Mohseni, Shahin

“…β-blocker therapy has been positively associated with improved survival in patients undergoing oncologic colorectal resection. This study investigates if the…”
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Predicting 1-Year Mortality after Hip Fracture Surgery: An Evaluation of Multiple Machine Learning Approaches by Forssten, Maximilian Peter, Bass, Gary Alan, Ismail, Ahmad Mohammad, Mohseni, Shahin, Cao, Yang

“…Postoperative death within 1 year following hip fracture surgery is reported to be up to 27%. In the current study, we benchmarked the predictive precision and…”
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Murderous Racism as Normal Psychosis: The Case of Dylann Roof by Bass, Alan

“…Dylann Roof killed nine people in a Black church in 2015 in order to start a “war” between the white and Black races. This case is used here to develop a…”
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Challenges in managing acute appendicitis differ across Europe: patient and system-level insights from observational cohort study data comparing two European countries by Martínez Casas, Isidro, Perea Del Pozo, Eduardo, Forssten, Maximilian Peter, Durán Muñoz-Cruzado, Virginia, Mohseni, Shahin, Bass, Gary Alan, Bass, Gary Alan, Mohseni, Shahin, Kaplan, Lewis J, Ahl-Hulme, Rebecka, Biloslavo, Alan, Cao, Yang, Forssten, Maximilian P, Kurihara, Hayato, Martinez-Casas, Isidro, Pereira, Jorge, Pourlotfi, Arvid, Ryan, Éanna J, Tolonen, Matti, Bass, Gary Alan, Segura-Sampedro, Juan José, Santos, Esther Pilar García, Estaire-Gómez, Mercedes, Colás-Ruiz, Enrique, Alvarez, Marta Merayo, Rodríguez-Haro, Carmen, Coltell, Izaskun Balciscueta, Pelloni, Maria, Ruiz, Jose Antonio Lopez, Olavarria, Aitor Landaluce, Moreira, Claudia Cristina Lopes, Prado, Cristina González, Mendoza-Moreno, Fernando, Sánchez-Guillén, Luis, Antona, Francisco Blanco, Campos-Serra, Andrea, Muñoz-Cruzado, Virginia Durán, Turrado-Rodriguez, Victor, Escartín, Alfredo, Fernandez, Estela Membrilla, Jiménez, María Lourdes García, Toro, Jose Antonio Becerra, Ahl-Hulme, Rebecka, Forsten, Maximilian Peter, Cao, Yang, Pourlotfti, Arvid

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Non-clinical evaluation of ventricular repolarization (ICH S7B): Results of an interim survey of international pharmaceutical companies by Friedrichs, Gregory S., Patmore, Leslie, Bass, Alan

“…The propensity of drugs to cause a potentially fatal arrhythmia, torsades des pointes (TdP), is a significant public health issue. The draft International…”
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Racial disparities in end-of-life suffering within surgical intensive care units by Haddad, Diane N, Meredyth, Nicole, Hatchimonji, Justin, Merulla, Elizabeth, Matta, Amy, Saucier, Jason, Sharoky, Catherine E, Bass, Gary Alan, Pascual, Jose L, Martin, Niels D

“…BackgroundEnd-of-life (EOL) care is associated with high resource utilization. Recognizing and effectively communicating that EOL is near promotes more…”
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Developing and validating a scoring system for measuring frailty in patients with hip fracture: a novel model for predicting short-term postoperative mortality by Forssten, Maximilian Peter, Cao, Yang, Trivedi, Dhanisha Jayesh, Ekestubbe, Lovisa, Borg, Tomas, Bass, Gary Alan, Mohammad Ismail, Ahmad, Mohseni, Shahin

“…ObjectivesFrailty is common among patients with hip fracture and may, in part, contribute to the increased risk of mortality and morbidity after hip fracture…”
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The Accuracy of Point-of-Care Ultrasound (POCUS) in Acute Gallbladder Disease by Dumbrava, Bogdan-Daniel, Bass, Gary Alan, Jumean, Amro, Birido, Nuha, Corbally, Martin, Pereira, Jorge, Biloslavo, Alan, Zago, Mauro, Walsh, Thomas Noel

“…There is increasing recognition that point-of-care ultrasound (POCUS), performed by the clinician at the bedside, can be a natural extension of the clinical…”
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Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society by Bass, Alan S, Vargas, Hugo M, Valentin, Jean-Pierre, Kinter, Lewis B, Hammond, Tim, Wallis, Rob, Siegl, Peter K S, Yamamoto, Keiji

“…In recognition of the tenth anniversary of the Safety Pharmacology Society (SPS), this review summarizes the significant events of the past 10years that have…”
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Mode of anesthesia is not associated with outcomes following emergency hip fracture surgery: a population-level cohort study by Mohammad Ismail, Ahmad, Forssten, Maximilian Peter, Bass, Gary Alan, Trivedi, Dhanisha Jayesh, Ekestubbe, Lovisa, Ioannidis, Ioannis, Duffy, Caoimhe C, Peden, Carol J, Mohseni, Shahin

“…BackgroundHip fractures often occur in frail patients with several comorbidities. In those undergoing emergency surgery, determining the optimal anesthesia…”
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Gamification in Critical Care Education and Practice by Bass, Gary Alan, Chang, Cherylee W J, Sorce, Lauren R, Subramanian, Sanjay, Laytin, Adam D, Somodi, Reka, Gray, Jaime R, Lane-Fall, Meghan, Kaplan, Lewis J

“…To explore gamification as an alternative approach to healthcare education and its potential applications to critical care. English language manuscripts…”
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