Search Results - "Bass, Adam J."

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer by Kim, Seung Tae, Cristescu, Razvan, Bass, Adam J., Kim, Kyoung-Mee, Odegaard, Justin I., Kim, Kyung, Liu, Xiao Qiao, Sher, Xinwei, Jung, Hun, Lee, Mijin, Lee, Sujin, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Lee, Hyuk, Choi, Mingew, Talasaz, AmirAli, Kang, Peter Soonmo, Cheng, Jonathan, Loboda, Andrey, Lee, Jeeyun, Kang, Won Ki

“…Clinical studies support the efficacy of programmed cell death 1 (PD-1) targeted therapy in a subset of patients with metastatic gastric cancer (mGC). With the…”
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IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment by Karakasheva, Tatiana A, Lin, Eric W, Tang, Qiaosi, Qiao, Edmund, Waldron, Todd J, Soni, Monica, Klein-Szanto, Andres J, Sahu, Varun, Basu, Devraj, Ohashi, Shinya, Baba, Kiichiro, Giaccone, Zachary T, Walker, Sarah R, Frank, David A, Wileyto, E Paul, Long, Qi, Dunagin, Margaret C, Raj, Arjun, Diehl, J Alan, Wong, K K, Bass, Adam J, Rustgi, Anil K

“…The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently…”
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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis by Rampal, Raajit, Al-Shahrour, Fatima, Abdel-Wahab, Omar, Patel, Jay P., Brunel, Jean-Philippe, Mermel, Craig H., Bass, Adam J., Pretz, Jennifer, Ahn, Jihae, Hricik, Todd, Kilpivaara, Outi, Wadleigh, Martha, Busque, Lambert, Gilliland, D. Gary, Golub, Todd R., Ebert, Benjamin L., Levine, Ross L.

“…Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of…”
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Paired exome analysis of Barrett's esophagus and adenocarcinoma by Stachler, Matthew D, Taylor-Weiner, Amaro, Peng, Shouyong, McKenna, Aaron, Agoston, Agoston T, Odze, Robert D, Davison, Jon M, Nason, Katie S, Loda, Massimo, Leshchiner, Ignaty, Stewart, Chip, Stojanov, Petar, Seepo, Sara, Lawrence, Michael S, Ferrer-Torres, Daysha, Lin, Jules, Chang, Andrew C, Gabriel, Stacey B, Lander, Eric S, Beer, David G, Getz, Gad, Carter, Scott L, Bass, Adam J

“…Adam Bass, Gad Getz, Scott Carter and colleagues report the whole-exome sequences of 25 pairs of esophageal adenocarcinoma and Barrett's esophagus. They…”
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Detection of Mutations in Barrett’s Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma by Stachler, Matthew D., Camarda, Nicholas D., Deitrick, Christopher, Kim, Anthony, Agoston, Agoston T., Odze, Robert D., Hornick, Jason L., Nag, Anwesha, Thorner, Aaron R., Ducar, Matthew, Noffsinger, Amy, Lash, Richard H., Redston, Mark, Carter, Scott L., Davison, Jon M., Bass, Adam J.

“…Barrett’s esophagus (BE) is the greatest risk factor for esophageal adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer…”
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Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma by Natsuizaka, Mitsuteru, Whelan, Kelly A., Kagawa, Shingo, Tanaka, Koji, Giroux, Veronique, Chandramouleeswaran, Prasanna M., Long, Apple, Sahu, Varun, Darling, Douglas S., Que, Jianwen, Yang, Yizeng, Katz, Jonathan P., Wileyto, E. Paul, Basu, Devraj, Kita, Yoshiaki, Natsugoe, Shoji, Naganuma, Seiji, Klein-Szanto, Andres J., Diehl, J. Alan, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Nakagawa, Hiroshi

“…Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a…”
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Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression by Xu, Chunxiao, Fillmore, Christine M., Koyama, Shohei, Wu, Hongbo, Zhao, Yanqiu, Chen, Zhao, Herter-Sprie, Grit S., Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Reibel, Jacob B., Walton, Zandra, Ji, Hongbin, Watanabe, Hideo, Jänne, Pasi A., Castrillon, Diego H., Rustgi, Anil K., Bass, Adam J., Freeman, Gordon J., Padera, Robert F., Dranoff, Glenn, Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin

“…Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten…”
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Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer? by Goedegebuure, Ruben S A, de Klerk, Leonie K, Bass, Adam J, Derks, Sarah, Thijssen, Victor L J L

“…Radiotherapy has been used for the treatment of cancer for over a century. Throughout this period, the therapeutic benefit of radiotherapy has continuously…”
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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma by Qie, Shuo, Yoshida, Akihiro, Parnham, Stuart, Oleinik, Natalia, Beeson, Gyda C., Beeson, Craig C., Ogretmen, Besim, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Diehl, J. Alan

“…The dysregulation of Fbxo4-cyclin D1 axis occurs at high frequency in esophageal squamous cell carcinoma (ESCC), where it promotes ESCC development and…”
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Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer by Zhang, Haisheng, Schaefer, Antje, Wang, Yichen, Hodge, Richard G, Blake, Devon R, Diehl, J Nathaniel, Papageorge, Alex G, Stachler, Matthew D, Liao, Jennifer, Zhou, Jin, Wu, Zhong, Akarca, Fahire G, de Klerk, Leonie K, Derks, Sarah, Pierobon, Mariaelena, Hoadley, Katherine A, Wang, Timothy C, Church, George, Wong, Kwok-Kin, Petricoin, Emanuel F, Cox, Adrienne D, Lowy, Douglas R, Der, Channing J, Bass, Adam J

“…Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of…”
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Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer by Dang, Fabin, Nie, Li, Zhou, Jin, Shimizu, Kouhei, Chu, Chen, Wu, Zhong, Fassl, Anne, Ke, Shizhong, Wang, Yuangao, Zhang, Jinfang, Zhang, Tao, Tu, Zhenbo, Inuzuka, Hiroyuki, Sicinski, Piotr, Bass, Adam J., Wei, Wenyi

“…Although inhibitors targeting CDK4/6 kinases (CDK4/6i) have shown promising clinical prospect in treating ER+/HER2- breast cancers, acquired drug resistance is…”
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Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis by Chang, Wenju, Wang, Hongshan, Kim, Woosook, Liu, Yang, Deng, Huan, Liu, Haibo, Jiang, Zhengyu, Niu, Zhengchuan, Sheng, Weiwei, Nápoles, Osmel Companioni, Sun, Yihong, Xu, Jianmin, Sepulveda, Antonia, Hayakawa, Yoku, Bass, Adam J., Wang, Timothy C.

“…Cancer is believed to arise from stem cells, but mechanisms that limit the acquisition of mutations and tumor development have not been well defined. We show…”
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Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy by Hai, Josephine, Zhang, Hua, Zhou, Jin, Wu, Zhong, Chen, Ting, Papadopoulos, Eleni, Dowling, Catríona M, Pyon, Val, Pan, Yuanwang, Liu, Jie Bin, Bronson, Roderick T, Silver, Heather, Lizotte, Patrick H, Deng, Jiehui, Campbell, Joshua D, Sholl, Lynette M, Ng, Christine, Tsao, Ming-Sound, Thakurdin, Cassandra, Bass, Adam J, Wong, Kwok-Kin

“…Lung squamous cell carcinoma (LSCC) is a deadly disease for which only a subset of patients responds to immune checkpoint blockade (ICB) therapy. Therefore,…”
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Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma by Kim, Jihun, Fox, Cameron, Peng, Shouyong, Pusung, Mark, Pectasides, Eirini, Matthee, Eric, Hong, Yong Sang, Do, In-Gu, Jang, Jiryeon, Thorner, Aaron R, Van Hummelen, Paul, Rustgi, Anil K, Wong, Kwok-Kin, Zhou, Zhongren, Tang, Ping, Kim, Kyoung-Mee, Lee, Jeeyun, Bass, Adam J

“…Patients with gastric and esophageal (GE) adenocarcinoma tumors in which the oncogene ERBB2 has been amplified are routinely treated with a combination of…”
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Sox2 Suppresses Gastric Tumorigenesis in Mice by Sarkar, Abby, Huebner, Aaron J., Sulahian, Rita, Anselmo, Anthony, Xu, Xinsen, Flattery, Kyle, Desai, Niyati, Sebastian, Carlos, Yram, Mary Anna, Arnold, Katrin, Rivera, Miguel, Mostoslavsky, Raul, Bronson, Roderick, Bass, Adam J., Sadreyev, Ruslan, Shivdasani, Ramesh A., Hochedlinger, Konrad

“…Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during…”
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Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma by Bao, Chunyang, Tourdot, Richard W., Brunette, Gregory J., Stewart, Chip, Sun, Lili, Baba, Hideo, Watanabe, Masayuki, Agoston, Agoston T., Jajoo, Kunal, Davison, Jon M., Nason, Katie S., Getz, Gad, Wang, Kenneth K., Imamura, Yu, Odze, Robert, Bass, Adam J., Stachler, Matthew D., Zhang, Cheng-Zhong

“…The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise…”
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RhoA Mutations Identified in Diffuse Gastric Cancer by Zhou, Jin, Hayakawa, Yoku, Wang, Timothy C., Bass, Adam J.

“…The diffuse-type histologic variant of gastric cancer is characterized by highly invasive growth patterns and lack of cellular cohesion. Two recent studies…”
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Comparative Genomics of Esophageal Adenocarcinoma and Squamous Cell Carcinoma by Bandla, Santhoshi, PhD, Pennathur, Arjun, MD, Luketich, James D., MD, Beer, David G., PhD, Lin, Lin, MD, PhD, Bass, Adam J., MD, Godfrey, Tony E., PhD, Litle, Virginia R., MD

“…Background Esophageal cancer consists of two major histologic types: esophageal squamous cell carcinoma (ESCC), predominant globally, and esophageal…”
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Profiling critical cancer gene mutations in clinical tumor samples by MacConaill, Laura E, Campbell, Catarina D, Kehoe, Sarah M, Bass, Adam J, Hatton, Charles, Niu, Lili, Davis, Matt, Yao, Keluo, Hanna, Megan, Mondal, Chandrani, Luongo, Lauren, Emery, Caroline M, Baker, Alissa C, Philips, Juliet, Goff, Deborah J, Fiorentino, Michelangelo, Rubin, Mark A, Polyak, Kornelia, Chan, Jennifer, Wang, Yuexiang, Fletcher, Jonathan A, Santagata, Sandro, Corso, Gianni, Roviello, Franco, Shivdasani, Ramesh, Kieran, Mark W, Ligon, Keith L, Stiles, Charles D, Hahn, William C, Meyerson, Matthew L, Garraway, Levi A

“…Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput…”
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CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma by Zhou, Jin, Wu, Zhong, Wong, Gabrielle, Pectasides, Eirini, Nagaraja, Ankur, Stachler, Matthew, Zhang, Haikuo, Chen, Ting, Zhang, Haisheng, Liu, Jie Bin, Xu, Xinsen, Sicinska, Ewa, Sanchez-Vega, Francisco, Rustgi, Anil K., Diehl, J. Alan, Wong, Kwok-Kin, Bass, Adam J.

“…Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations…”
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