Search Results - "Basle, Arnaud"

Complex pectin metabolism by gut bacteria reveals novel catalytic functions by Ndeh, Didier, Rogowski, Artur, Cartmell, Alan, Luis, Ana S., Baslé, Arnaud, Gray, Joseph, Venditto, Immacolata, Briggs, Jonathon, Zhang, Xiaoyang, Labourel, Aurore, Terrapon, Nicolas, Buffetto, Fanny, Nepogodiev, Sergey, Xiao, Yao, Field, Robert A., Zhu, Yanping, O’Neill, Malcolm A., Urbanowicz, Breeanna R., York, William S., Davies, Gideon J., Abbott, D. Wade, Ralet, Marie-Christine, Martens, Eric C., Henrissat, Bernard, Gilbert, Harry J.

“…The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single…”
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Glycan complexity dictates microbial resource allocation in the large intestine by Rogowski, Artur, Briggs, Jonathon A., Mortimer, Jennifer C., Tryfona, Theodora, Terrapon, Nicolas, Lowe, Elisabeth C., Baslé, Arnaud, Morland, Carl, Day, Alison M., Zheng, Hongjun, Rogers, Theresa E., Thompson, Paul, Hawkins, Alastair R., Yadav, Madhav P., Henrissat, Bernard, Martens, Eric C., Dupree, Paul, Gilbert, Harry J., Bolam, David N.

“…The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which…”
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A single sulfatase is required to access colonic mucin by a gut bacterium by Luis, Ana S., Jin, Chunsheng, Pereira, Gabriel Vasconcelos, Glowacki, Robert W. P., Gugel, Sadie R., Singh, Shaleni, Byrne, Dominic P., Pudlo, Nicholas A., London, James A., Baslé, Arnaud, Reihill, Mark, Oscarson, Stefan, Eyers, Patrick A., Czjzek, Mirjam, Michel, Gurvan, Barbeyron, Tristan, Yates, Edwin A., Hansson, Gunnar C., Karlsson, Niclas G., Cartmell, Alan, Martens, Eric C.

“…Humans have co-evolved with a dense community of microbial symbionts that inhabit the lower intestine. In the colon, secreted mucus creates a barrier that…”
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Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides by Luis, Ana S., Briggs, Jonathon, Zhang, Xiaoyang, Farnell, Benjamin, Ndeh, Didier, Labourel, Aurore, Baslé, Arnaud, Cartmell, Alan, Terrapon, Nicolas, Stott, Katherine, Lowe, Elisabeth C., McLean, Richard, Shearer, Kaitlyn, Schückel, Julia, Venditto, Immacolata, Ralet, Marie-Christine, Henrissat, Bernard, Martens, Eric C., Mosimann, Steven C., Abbott, D. Wade, Gilbert, Harry J.

“…The major nutrients available to human colonic Bacteroides species are glycans, exemplified by pectins, a network of covalently linked plant cell wall…”
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Identification of d-arabinan-degrading enzymes in mycobacteria by Al-Jourani, Omar, Benedict, Samuel T., Ross, Jennifer, Layton, Abigail J., van der Peet, Phillip, Marando, Victoria M., Bailey, Nicholas P., Heunis, Tiaan, Manion, Joseph, Mensitieri, Francesca, Franklin, Aaron, Abellon-Ruiz, Javier, Oram, Sophia L., Parsons, Lauren, Cartmell, Alan, Wright, Gareth S. A., Baslé, Arnaud, Trost, Matthias, Henrissat, Bernard, Munoz-Munoz, Jose, Hirt, Robert P., Kiessling, Laura L., Lovering, Andrew L., Williams, Spencer J., Lowe, Elisabeth C., Moynihan, Patrick J.

“…Bacterial cell growth and division require the coordinated action of enzymes that synthesize and degrade cell wall polymers. Here, we identify enzymes that…”
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A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation by Cartmell, Alan, Muñoz-Muñoz, Jose, Briggs, Jonathon A., Ndeh, Didier A., Lowe, Elisabeth C., Baslé, Arnaud, Terrapon, Nicolas, Stott, Katherine, Heunis, Tiaan, Gray, Joe, Yu, Li, Dupree, Paul, Fernandes, Pearl Z., Shah, Sayali, Williams, Spencer J., Labourel, Aurore, Trost, Matthias, Henrissat, Bernard, Gilbert, Harry J.

“…Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a…”
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Structural basis for Mep2 ammonium transceptor activation by phosphorylation by van den Berg, Bert, Chembath, Anupama, Jefferies, Damien, Basle, Arnaud, Khalid, Syma, Rutherford, Julian C.

“…Mep2 proteins are fungal transceptors that play an important role as ammonium sensors in fungal development. Mep2 activity is tightly regulated by…”
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A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression by Wilson, William C, Hornig-Do, Hue-Tran, Bruni, Francesco, Chang, Jeong Ho, Jourdain, Alexis A, Martinou, Jean-Claude, Falkenberg, Maria, Spåhr, Henrik, Larsson, Nils-Göran, Lewis, Richard J, Hewitt, Lorraine, Baslé, Arnaud, Cross, Harold E, Tong, Liang, Lebel, Robert R, Crosby, Andrew H, Chrzanowska-Lightowlers, Zofia M A, Lightowlers, Robert N

“…The p.N478D missense mutation in human mitochondrial poly(A) polymerase (mtPAP) has previously been implicated in a form of spastic ataxia with optic atrophy…”
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Target highlights from the first post‐PSI CASP experiment (CASP12, May–August 2016) by Kryshtafovych, Andriy, Albrecht, Reinhard, Baslé, Arnaud, Bule, Pedro, Caputo, Alessandro T., Carvalho, Ana Luisa, Chao, Kinlin L., Diskin, Ron, Fidelis, Krzysztof, Fontes, Carlos M. G. A., Fredslund, Folmer, Gilbert, Harry J., Goulding, Celia W., Hartmann, Marcus D., Hayes, Christopher S., Herzberg, Osnat, Hill, Johan C., Joachimiak, Andrzej, Kohring, Gert‐Wieland, Koning, Roman I., Lo Leggio, Leila, Mangiagalli, Marco, Michalska, Karolina, Moult, John, Najmudin, Shabir, Nardini, Marco, Nardone, Valentina, Ndeh, Didier, Nguyen, Thanh‐Hong, Pintacuda, Guido, Postel, Sandra, van Raaij, Mark J., Roversi, Pietro, Shimon, Amir, Singh, Abhimanyu K., Sundberg, Eric J., Tars, Kaspars, Zitzmann, Nicole, Schwede, Torsten

“…The functional and biological significance of the selected CASP12 targets are described by the authors of the structures. The crystallographers discuss the…”
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Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus by Ndeh, Didier, Baslé, Arnaud, Strahl, Henrik, Yates, Edwin A., McClurgg, Urszula L., Henrissat, Bernard, Terrapon, Nicolas, Cartmell, Alan

“…The human gut microbiota (HGM), which is critical to human health, utilises complex glycans as its major carbon source. Glycosaminoglycans represent an…”
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Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown by Crouch, Lucy I., Liberato, Marcelo V., Urbanowicz, Paulina A., Baslé, Arnaud, Lamb, Christopher A., Stewart, Christopher J., Cooke, Katie, Doona, Mary, Needham, Stephanie, Brady, Richard R., Berrington, Janet E., Madunic, Katarina, Wuhrer, Manfred, Chater, Peter, Pearson, Jeffery P., Glowacki, Robert, Martens, Eric C., Zhang, Fuming, Linhardt, Robert J., Spencer, Daniel I. R., Bolam, David N.

“…The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some…”
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Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion by Somboon, Kamolrat, Doble, Anne, Bulmer, David, Baslé, Arnaud, Khalid, Syma, van den Berg, Bert

“…In modern societies, biodegradation of hydrophobic pollutants generated by industry is important for environmental and human health. In Gram-negative bacteria,…”
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Structure and assembly of the S-layer in C. difficile by Lanzoni-Mangutchi, Paola, Banerji, Oishik, Wilson, Jason, Barwinska-Sendra, Anna, Kirk, Joseph A., Vaz, Filipa, O’Beirne, Shauna, Baslé, Arnaud, El Omari, Kamel, Wagner, Armin, Fairweather, Neil F., Douce, Gillian R., Bullough, Per A., Fagan, Robert P., Salgado, Paula S.

“…Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here,…”
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Insights into SusCD-mediated glycan import by a prominent gut symbiont by Gray, Declan A., White, Joshua B. R., Oluwole, Abraham O., Rath, Parthasarathi, Glenwright, Amy J., Mazur, Adam, Zahn, Michael, Baslé, Arnaud, Morland, Carl, Evans, Sasha L., Cartmell, Alan, Robinson, Carol V., Hiller, Sebastian, Ranson, Neil A., Bolam, David N., van den Berg, Bert

“…In Bacteroidetes, one of the dominant phyla of the mammalian gut, active uptake of large nutrients across the outer membrane is mediated by SusCD protein…”
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Structural basis for nutrient acquisition by dominant members of the human gut microbiota by Glenwright, Amy J., Pothula, Karunakar R., Bhamidimarri, Satya P., Chorev, Dror S., Baslé, Arnaud, Firbank, Susan J., Zheng, Hongjun, Robinson, Carol V., Winterhalter, Mathias, Kleinekathöfer, Ulrich, Bolam, David N., van den Berg, Bert

“…The authors present structures of nutrient transport complexes of the commensal bacterium Bacteroides thetaiotaomicron and the mechanism by which it imports…”
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Important Structural Features of Thiolate-Rich Four-Helix Bundles for Cu(I) Uptake and Removal by Lee, Jaeick, Dalton, Rosemary A., Baslé, Arnaud, Vita, Nicolas, Dennison, Christopher

“…A family of bacterial copper storage proteins (the Csps) possess thiolate-lined four-helix bundles whose cores can be filled with Cu­(I) ions. The majority of…”
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Structural Basis for Silicic Acid Uptake by Higher Plants by van den Berg, Bert, Pedebos, Conrado, Bolla, Jani R., Robinson, Carol V., Baslé, Arnaud, Khalid, Syma

“…[Display omitted] •NIP channels mediate uptake of metalloids such as silicic acid in plants.•The first structure of a NIP metalloid porin is reported.•OsNIP2;1…”
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An evolutionary path to altered cofactor specificity in a metalloenzyme by Barwinska-Sendra, Anna, Garcia, Yuritzi M., Sendra, Kacper M., Baslé, Arnaud, Mackenzie, Eilidh S., Tarrant, Emma, Card, Patrick, Tabares, Leandro C., Bicep, Cédric, Un, Sun, Kehl-Fie, Thomas E., Waldron, Kevin J.

“…Almost half of all enzymes utilize a metal cofactor. However, the features that dictate the metal utilized by metalloenzymes are poorly understood, limiting…”
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How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans by Cartmell, Alan, Lowe, Elisabeth C., Baslé, Arnaud, Firbank, Susan J., Ndeh, Didier A., Murray, Heath, Terrapon, Nicolas, Lombard, Vincent, Henrissat, Bernard, Turnbull, Jeremy E., Czjzek, Mirjam, Gilbert, Harry J., Bolam, David N.

“…The human microbiota, which plays an important role in health and disease, uses complex carbohydrates as a major source of nutrients. Utilization hierarchy…”
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Visualizing Biological Copper Storage: The Importance of Thiolate‐Coordinated Tetranuclear Clusters by Baslé, Arnaud, Platsaki, Semeli, Dennison, Christopher

“…Bacteria possess cytosolic proteins (Csp3s) capable of binding large quantities of copper and preventing toxicity. Crystal structures of a Csp3 plus increasing…”
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