Search Results - "Baskar, Reema"

Single-cell metabolic profiling of human cytotoxic T cells by Hartmann, Felix J., Mrdjen, Dunja, McCaffrey, Erin, Glass, David R., Greenwald, Noah F., Bharadwaj, Anusha, Khair, Zumana, Verberk, Sanne G. S., Baranski, Alex, Baskar, Reema, Graf, William, Van Valen, David, Van den Bossche, Jan, Angelo, Michael, Bendall, Sean C.

“…Cellular metabolism regulates immune cell activation, differentiation and effector functions, but current metabolic approaches lack single-cell resolution and…”
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Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells by Kimmey, Samuel C., Borges, Luciene, Baskar, Reema, Bendall, Sean C.

“…Cellular products derived from the activity of DNA, RNA, and protein synthesis collectively control cell identity and function. Yet there is little information…”
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Revealing new biology from multiplexed, metal-isotope-tagged, single-cell readouts by Baskar, Reema, Kimmey, Sam C., Bendall, Sean C.

“…Mass cytometry (MC) is a recent technology that pairs plasma-based ionization of cells in suspension with time-of-flight (TOF) mass spectrometry to sensitively…”
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Chromatin Content Capture Reveals Acute Leukaemia Oncogenic Vulnerability Point in Human B Cell Development by Baskar, Reema, Favaro, Patricia, Reynolds, Warren D., Domizi, Pablo, Tsai, Albert G, Davis, Kara L., Bendall, Sean

“…Human B cell development in adult human bone marrow (BM) is tightly regulated through well-defined stages to produce adaptive immune cells with assembled and…”
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Decoding Cellular Diversity in Complex Biological Systems by Baskar, Reema

“…Biological processes are inherently dynamic, complex and exhibit cell-to-cell variation. It is this variation, in multiple levels of cellular information that…”
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2015 – A HIGHLY MULTIPLEXED SINGLE CELL PROTEOMIC SCREEN REVEALS THE PHENOTYPIC AND FUNCTIONAL LANDSCAPE OF THE HUMAN LYMPHO-MYELOID DIFFERENTIATION AXIS by Kim, YeEun, Caleron, Ariel, Glass, David, Tsai, Albert, Favaro, Patricia, Baskar, Reema, Hartmann, Felix, Greenleaf, William, Bendall, Sean

“…While single-cell sequencing techniques have elucidated transcriptomic and epigenetic heterogeneities among human hematopoietic stem and progenitor cell (HSPC)…”
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Ikaros Mediates Antigen Escape Following CD19 CAR T Cell Therapy in r/r B-ALL by Domizi, Pablo, Sarno, Jolanda, Jager, Astraea, Baskar, Reema, Reynolds, Warren D., Sahaf, Bita, Bendall, Sean, Mullighan, Charles G., Leahy, Allison Barz, Myers, Regina M., Grupp, Stephan A., Sotillo, Elena, Barrett, David, Davis, Kara L.

“…Despite impressive response to front-line treatment, relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) remains one of the most common…”
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Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage by Grandi, Fiorella Carla, Baskar, Reema, Smeriglio, Piera, Murkherjee, Shravani, Indelli, Pier Francesco, Amanatullah, Derek F, Goodman, Stuart, Chu, Constance, Bendall, Sean, Bhutani, Nidhi

“…Aging or injury leads to degradation of the cartilage matrix and the development of osteoarthritis (OA). Because of a paucity of single-cell studies of OA…”
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Long-Term Follow-up of CD19/22 CAR Therapy in Children and Young Adults with B-ALL Reveals Efficacy, Tolerability and High Survival Rates When Coupled with Hematopoietic Stem Cell Transplantation by Schultz, Liora M., Ramakrishna, Sneha, Baskar, Reema, Richards, Rebecca M, Moon, Jennifer, Baggott, Christina, Fujimoto, Michelle, Kunicki, Michael, Li, Amy, Jariwala, Sneha, Erickson, Courtney, Jacobs, Ashley, Yamabe, Karen, Barsan, Valentin, Majzner, Robbie G., Egeler, Emily L., Mavroukakis, Sharon, Ehlinger, Zachary, Reynolds, Warren D., Sahaf, Bita, Muffly, Lori, Frank, Matthew J, Gramstrup, Anne-Louise, Chinnasamy, Harshini, Patel, Shabnum, Miklos, David B., Feldman, Steven A., Mackall, Crystal L., Davis, Kara L.

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Supervised dimensionality reduction for exploration of single-cell data by HSS-LDA by Amouzgar, Meelad, Glass, David R., Baskar, Reema, Averbukh, Inna, Kimmey, Samuel C., Tsai, Albert G., Hartmann, Felix J., Bendall, Sean C.

“…Single-cell technologies generate large, high-dimensional datasets encompassing a diversity of omics. Dimensionality reduction captures the structure and…”
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Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment by Baskar, Reema, Chen, Amy F., Favaro, Patricia, Reynolds, Warren, Mueller, Fabian, Borges, Luciene, Jiang, Sizun, Park, Hyun Shin, Kool, Eric T., Greenleaf, William J., Bendall, Sean C.

“…Master transcription factors (TFs) directly regulate present and future cell states by binding DNA regulatory elements and driving gene-expression programs…”
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Abstract B052: IKAROS mediates antigen escape following CD19- or CD22-targeted immunotherapies in r/r B-ALL by Domizi, Pablo, Sarno, Jolanda, Jager, Astraea, Merchant, Milton, Pacheco, Kaithlen, Yamada-Hunter, Sean, Rotiroti, Maria Caterina, Liu, Yuxuan, Baskar, Reema, Reynolds, Warren, Sworder, Brian, Sahaf, Bita, Bendall, Sean, Mullighan, Charles, Alizadeh, Ash, Leahy, Allison, Myers, Regina, Grupp, Stephan, Majzner, Robbie, Barrett, David, Sotillo, Elena, Davis, Kara

“…Abstract CD19 CAR T cell (CART19) therapy has shown impressive results in relapsed or refractory B cell acute lymphoblastic leukemia (r/r B-ALL). However, 30 –…”
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362 Defining T cell exhaustion and memory correlates of GD2 CAR T cell expansion in pediatric patients with solid tumor malignancies by Murty, Tara, Ramakrishna, Sneha, Kaczanowska, Sabina, Contreras, Cristina, Duault, Caroline, Balasubrahmanyam, Priyanka, Reynolds, Warren, Baskar, Reema, Jhaveri, Aashna, Liu, Yang, Altreuter, Jennifer, Michor, Franziska, Pichavant, Mina, Sahaf, Bita, Bendall, Sean, Holden Maecker, Merchant, Melinda, Mackall, Crystal, Kaplan, Rosandra

“…BackgroundChimeric antigen receptor T cells (CAR-Ts) hold promising therapeutic potential for solid tumors but have yet to produce consistent durable responses…”
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3059 – UNRAVELLING HUMAN HEMATOPOIETIC PROGENITOR CELL DIVERSITY THROUGH ASSOCIATION WITH INTRINSIC REGULATORY FACTORS by Favaro, Patricia, Glass, David, Borges, Luciene, Baskar, Reema, Reynolds, Warren, Ho, Daniel, Bruce, Trevor, Tebaykin, Dmitry, Tsai, Albert, Shestopalov, Ilya, Bendall, Sean

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TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis by Baskar, Reema, Fienberg, Harris G, Khair, Zumana, Favaro, Patricia, Kimmey, Sam, Green, Douglas R, Nolan, Garry P, Plevritis, Sylvia, Bendall, Sean C

“…TNFα-related apoptosis-inducing ligand (TRAIL), specifically initiates programmed cell death, but often fails to eradicate all cells, making it an ineffective…”
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Ikaros Mediates Antigen Escape Following CD19 CAR T Cell Therapy in r/r B-ALL by Domizi, Pablo, Sarno, Jolanda, Jager, Astraea, Baskar, Reema, Warren, Reynolds, Sahaf, Bita, Bendall, Sean, Mullighan, Charles G., Leahy, Allison B, Myers, Regina M., Grupp, Stephan A., Sotillo, Elena, Barrett, David M., Davis, Kara L

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4 - Ikaros Mediates Antigen Escape Following CD19 CAR T Cell Therapy in r/r B-ALL by Domizi, Pablo, Sarno, Jolanda, Jager, Astraea, Baskar, Reema, Warren, Reynolds, Sahaf, Bita, Bendall, Sean, Mullighan, Charles G., Leahy, Allison B, Myers, Regina M., Grupp, Stephan A., Sotillo, Elena, Barrett, David M., Davis, Kara L

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Abstract 2142: Immune determinants of CAR-T expansion in solid tumor patients receiving GD2 CAR-T cell therapy by Murty, Tara, Kaczanowska, Sabina, Alimadadi, Ahmad, Contreras, Cristina, Duault, Caroline, Balasubrahmanyan, Priyanka, Reynolds, Warren, Gutierrez, Norma, Baskar, Reema, Wu, Catherine, Michor, Franziska, Altreuter, Jennifer, Liu, Yang, Jhaveri, Aashna, Duong, Vandon, Anbunathan, Hima, Moravec, Radim, Hong, Joyce, Biswas, Roshni, Van Nostrand, Stephen, Lindsay, James, Pichavant, Mina, Sotillo, Elena, Sahaf, Bita, Bendall, Sean, Maecker, Holden, Highfill, Steven, Stroncek, David, Merchant, Melinda, Glod, John, Hedrick, Catherine, Mackall, Crystal, Ramakrishna, Sneha, Kaplan, Rosandra

“…Abstract Chimeric antigen receptor T cells (CAR-Ts) have demonstrated remarkable efficacy in leukemia and lymphomas but limited responses in solid tumors. We…”
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Abstract CT142: GD2.Ox40.CD28.z CAR T cell trial in neuroblastoma and osteosarcoma by Ramakrishna, Sneha, Kaczanowska, Sabina, Murty, Tara, Contreras, Cristina F., Merchant, Melinda, Glod, John, Gutierrez, Norma, Alimadadi, Ahmad, Stroncek, David, Highfill, Steven, Duault, Caroline, Subrahmanyam, Priyanka B., Holmes, Tyson, Reynolds, Warren, Baskar, Reema, Barge, Antoine, Lyon, Hayley, Moravec, Radim, Ranasinghe, Srinika, Yu, Joyce, Biswas, Roshni, Pollack, Samuel, Van Nostrand, Stephen, Lindsay, James, Pichavant, Mina, Sahaf, Bita, Bendall, Sean C., Gentles, Andrew J., Maecker, Holden, Hedrick, Catherine C., Mackall, Crystal, Kaplan, Rosandra

“…Abstract Background: Chimeric antigen receptor T cells (CARTs) hold promising therapeutic potential for refractory tumors. GD2 is a tumor antigen expressed on…”
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