Search Results - "Basile, S"

Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study) by Nguyen, Quan Dong, Schachar, Ronald A, Nduaka, Chudy I, Sperling, Marvin, Basile, Anthony S, Klamerus, Karen J, Chi-Burris, Katherine, Yan, Eric, Paggiarino, Dario A, Rosenblatt, Irit, Aitchison, Roger, Erlich, Shai S

“…To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the…”
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Peripheral benzodiazepine receptors and mitochondrial function by Casellas, Pierre, Galiegue, Sylvaine, Basile, Anthony S

“…For over 20 years, numerous investigations have focused on elucidating the function of the peripheral benzodiazepine receptor (PBR). This relatively small…”
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Management of transient ischemic attack or nondisabling stroke related to extracranial internal carotid artery stenosis by Kapila, Varun, MD, Jetty, Prasad, MD MSc, Basile, Vincenzo S., MD BEd, Dubois, Luc, MD MSc

“…Cerebrovascular disease is not only the third largest cause of death in Canada, it is also associated with substantial functional morbidity after an event. In…”
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Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice by Zhang, Weilie, Basile, Anthony S, Gomeza, Jesus, Volpicelli, Laura A, Levey, Allan I, Wess, Jurgen

“…Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play important roles in many fundamental central functions, including…”
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Pre-conceptual design of EU-DEMO divertor primary heat transfer systems by Vallone, E., Barucca, L., Basile, S., Ciattaglia, S., Di Maio, P.A., Federici, G., Giardina, M., Moscato, I., Quartararo, A., Tarallo, A.

“…In the frame of the activities promoted and encouraged by the EUROfusion Power Plant Physics and Technology (PPPT) department aimed at developing the EU-DEMO…”
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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function by Barger, Steven W., Basile, Anthony S.

“…Microglial activation as part of a chronic inflammatory response is a prominent component of Alzheimer's disease. Secreted forms of the β‐amyloid precursor…”
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Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? by Petronis, Arturas, Gottesman, Irving I, Kan, Peixiang, Kennedy, James L, Basile, Vincenzo S, Paterson, Andrew D, Popendikyte, Violeta

“…The goal of this pilot study was to explore the putative molecular mechanisms underlying the phenotypic discordance of monozygotic (MZ) twins. Thus, patterns…”
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Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients by Nguyen, Q D, Schachar, R A, Nduaka, C I, Sperling, M, Basile, A S, Klamerus, K J, Chi-Burris, K, Yan, E, Paggiarino, D A, Rosenblatt, I, Khan, A, Aitchison, R, Erlich, S S

“…Background To evaluate the safety, tolerability, pharmacokinetics, and dose-limiting toxicities of a single intravitreal (IVT) injection of PF-04523655, a…”
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Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures by Dahlin, Amber, Geier, Ethan, Stocker, Sophie L, Cropp, Cheryl D, Grigorenko, Elena, Bloomer, Michele, Siegenthaler, Julie, Xu, Lu, Basile, Anthony S, Tang-Liu, Diane D-S, Giacomini, Kathleen M

“…The barrier epithelia of the cornea and retina control drug and nutrient access to various compartments of the human eye. While ocular transporters are likely…”
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DRD2 and SLC6A3 moderate impact of maternal depressive symptoms on infant cortisol by Ludmer, Jaclyn A, Levitan, Robert, Gonzalez, Andrea, Kennedy, James, Villani, Vanessa, Masellis, Mario, Basile, Vincenzo S, Atkinson, Leslie

“…Highlights • DRD2 and SLC6A3 moderate impact of maternal depressive symptoms on infant cortisol • Infants with risk alleles and more symptomatic mothers show…”
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Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study by Robertson, Andrew D, Marzolini, Susan, Middleton, Laura E, Basile, Vincenzo S, Oh, Paul I, MacIntosh, Bradley J

“…Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the…”
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Pharmacogenomics in schizophrenia: the quest for individualized therapy by Basile, Vincenzo S., Masellis, Mario, Potkin, Steven G., Kennedy, James L.

“…There is strong evidence to suggest that genetic variation plays an important role in inter-individual differences in medication response and toxicity. The…”
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Identifying obstructive sleep apnea after stroke/TIA: evaluating four simple screening tools by Boulos, Mark I., MD, MSc, Wan, Anthony, Im, James, BSc, Elias, Sara, MD, Frankul, Fadi, MD, Atalla, Mina, BSc, Black, Sandra E., MD, Basile, Vincenzo S., MD, Sundaram, Arun, MD, Hopyan, Julia J., MD, Boyle, Karl, MB BCh, MSc, Gladstone, David J., MD, PhD, Murray, Brian J., MD, Swartz, Richard H., MD, PhD

“…Highlights • Obstructive sleep apnea (OSA) remains under-appreciated after stroke and TIA • We examined whether paper-based screening tools could rule out OSA…”
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Robot-assisted partial nephrectomy using the novel Hugo™ RAS system: Feasibility, setting and perioperative outcomes of the first off-clamp series by Prata, F, Ragusa, A, Civitella, A, Tuzzolo, P, Tedesco, F, Cacciatore, L, Iannuzzi, A, Callè, P, Raso, G, Fantozzi, M, Pira, M, Ricci, M, Pino, M, Minore, A, Basile, S, Testa, A, Crimi, VG, Deanesi, N, Travino, A, D’Addurno, G, Scarpa, RM, Papalia, R

“…Introduction: Hugo Robot-Assisted Surgery (RAS) System has been conceived with enhanced modularity but its role for nephron-sparing surgery setting still…”
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Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia by Basile, Anthony S, Fedorova, Irina, Zapata, Agustin, Liu, Xiaoguang, Shippenberg, Toni, Duttaroy, Alokesh, Yamada, Masahisa, Wess, Jurgen

“…Little is known about the physiological roles of the M 5 muscarinic receptor, the last member of the muscarinic receptor family (M 1 –M 5 ) to be cloned. In…”
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Total rectosigmoidectomy versus partial rectal resection in primary debulking surgery for advanced ovarian cancer by Plotti, F, Montera, R, Aloisi, A, Scaletta, G, Capriglione, S, Luvero, D, De Cicco Nardone, C, Basile, S, Benedetti Panici, P, Angioli, R

“…Abstract Purpose To compare in a sample of Italian patients intraoperative, perioperative complications, Quality of Life (QoL), recurrence rate and overall…”
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Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide by Wu, Sheng-Zhou, Bodles, Angela M, Porter, Mandy M, Griffin, W Sue T, Basile, Anthony S, Barger, Steven W

“…BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide…”
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ESR response of watch glasses to proton beams by Longo, A., Basile, S., Brai, M., Marrale, M., Tranchina, L.

“…In this paper we have analyzed the electron spin resonance (ESR) signal of watch glasses irradiated with ≈60 MeV proton beams in the dose range between 1 and…”
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Unattended Hospital and Home Sleep Apnea Testing Following Cerebrovascular Events by Boulos, Mark I., MD, MSc, Elias, Sara, MD, Wan, Anthony, BHSc, Im, James, BSc, Frankul, Fadi, MD, Atalla, Mina, BSc, Black, Sandra E., MD, Basile, Vincenzo S., MD, Sundaram, Arun, MD, Hopyan, Julia J., MD, Boyle, Karl, MB, MSc, Gladstone, David J., MD, PhD, Swartz, Richard H., MD, PhD, Murray, Brian J., MD

“…Background Home sleep apnea testing (HSAT) is an alternative to polysomnography for the detection of obstructive sleep apnea (OSA). We assessed the feasibility…”
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Movements in brain death: a systematic review by Saposnik, Gustavo, Basile, Vincenzo S, Young, G Bryan

“…Brain death is the irreversible lost of function of the brain including the brainstem. The presence of spontaneous or reflex movements constitutes a challenge…”
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