Search Results - "Basic Research in Cardiology"

Inflammation and fibrosis in murine models of heart failure by Bacmeister, Lucas, Schwarzl, Michael, Warnke, Svenja, Stoffers, Bastian, Blankenberg, Stefan, Westermann, Dirk, Lindner, Diana

“…Heart failure is a consequence of various cardiovascular diseases and associated with poor prognosis. Despite progress in the treatment of heart failure in the…”
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NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α by Zhou, Hao, Wang, Jin, Zhu, Pingjun, Zhu, Hong, Toan, Sam, Hu, Shunying, Ren, Jun, Chen, Yundai

“…Mitochondrial fission and mitophagy are considered key processes involved in the pathogenesis of cardiac microvascular ischemia reperfusion (IR) injury…”
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M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment by Liu, Shaojun, Chen, Jing, Shi, Jian, Zhou, Wenyi, Wang, Li, Fang, Weilun, Zhong, Yun, Chen, Xiaohui, Chen, Yanfang, Sabri, Abdelkarim, Liu, Shiming

“…The roles and the underlying mechanisms of M1-type macrophages in angiogenesis and postmyocardial infarction (MI) cardiac repair have remained unclear. In this…”
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Coronary microvascular obstruction: the new frontier in cardioprotection by Heusch, Gerd

“…Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from…”
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COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm? by Rizzo, Paola, Vieceli Dalla Sega, Francesco, Fortini, Francesca, Marracino, Luisa, Rapezzi, Claudio, Ferrari, Roberto

“…From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory…”
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IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation by Jung, Mira, Ma, Yonggang, Iyer, Rugmani Padmanabhan, DeLeon-Pennell, Kristine Y., Yabluchanskiy, Andriy, Garrett, Michael R., Lindsey, Merry L.

“…Inflammation resolution is important for scar formation following myocardial infarction (MI) and requires the coordinated actions of macrophages and…”
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Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level by Rao, Man, Wang, Xiliang, Guo, Guangran, Wang, Li, Chen, Shi, Yin, Pengbin, Chen, Kai, Chen, Liang, Zhang, Zemin, Chen, Xiao, Hu, Xueda, Hu, Shengshou, Song, Jiangping

“…Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart failure. Detailed deciphering gene expression perturbations and cell–cell…”
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Mapping macrophage polarization over the myocardial infarction time continuum by Mouton, Alan J., DeLeon-Pennell, Kristine Y., Rivera Gonzalez, Osvaldo J., Flynn, Elizabeth R., Freeman, Tom C., Saucerman, Jeffrey J., Garrett, Michael R., Ma, Yonggang, Harmancey, Romain, Lindsey, Merry L.

“…In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and scar formation. We hypothesized that macrophages undergo polarization…”
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Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice by Gregorius, Jonas, Wang, Chen, Stambouli, Oumaima, Hussner, Tanja, Qi, Yachao, Tertel, Tobias, Börger, Verena, Mohamud Yusuf, Ayan, Hagemann, Nina, Yin, Dongpei, Dittrich, Robin, Mouloud, Yanis, Mairinger, Fabian D., Magraoui, Fouzi El, Popa-Wagner, Aurel, Kleinschnitz, Christoph, Doeppner, Thorsten R., Gunzer, Matthias, Meyer, Helmut E., Giebel, Bernd, Hermann, Dirk M.

“…Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) promote stroke recovery. Within this process,…”
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Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases by Liu, Dongling, Zeng, Xiang, Li, Xiao, Mehta, Jawahar L., Wang, Xianwei

“…NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses and coordinates antimicrobial host defenses by…”
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Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery by Hausenloy, Derek J., Barrabes, Jose A., Bøtker, Hans Erik, Davidson, Sean M., Di Lisa, Fabio, Downey, James, Engstrom, Thomas, Ferdinandy, Péter, Carbrera-Fuentes, Hector A., Heusch, Gerd, Ibanez, Borja, Iliodromitis, Efstathios K., Inserte, Javier, Jennings, Robert, Kalia, Neena, Kharbanda, Rajesh, Lecour, Sandrine, Marber, Michael, Miura, Tetsuji, Ovize, Michel, Perez-Pinzon, Miguel A., Piper, Hans Michael, Przyklenk, Karin, Schmidt, Michael Rahbek, Redington, Andrew, Ruiz-Meana, Marisol, Vilahur, Gemma, Vinten-Johansen, Jakob, Yellon, Derek M., Garcia-Dorado, David

“…To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to…”
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IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action by Lecour, Sandrine, Andreadou, Ioanna, Bøtker, Hans Erik, Davidson, Sean M., Heusch, Gerd, Ruiz-Meana, Marisol, Schulz, Rainer, Zuurbier, Coert J., Ferdinandy, Péter, Hausenloy, Derek J.

“…Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new…”
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DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis by Zhou, Hao, Toan, Sam, Zhu, Pingjun, Wang, Jin, Ren, Jun, Zhang, Yingmei

“…DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a variety of cells…”
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Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function by Audia, Jonathon P., Yang, Xi-Ming, Crockett, Edward S., Housley, Nicole, Haq, Ehtesham Ul, O’Donnell, Kristen, Cohen, Michael V., Downey, James M., Alvarez, Diego F.

“…Patients with acute myocardial infarction receive a P2Y 12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated,…”
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Of mice and men: models and mechanisms of diabetic cardiomyopathy by Riehle, Christian, Bauersachs, Johann

“…Diabetes mellitus increases the risk of heart failure independent of co-existing hypertension and coronary artery disease. Although several molecular…”
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Coronary blood flow in heart failure: cause, consequence and bystander by Heusch, Gerd

“…Heart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate perfusion and normal bodily functions, initially during…”
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The RISK pathway and beyond by Rossello, Xavier, Yellon, Derek M.

“…Research on cardioprotection has attracted considerable attention during the past 30 years following the discovery of ischemic preconditioning with great…”
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Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis by Mouton, Alan J., Ma, Yonggang, Rivera Gonzalez, Osvaldo J., Daseke, Michael J., Flynn, Elizabeth R., Freeman, Tom C., Garrett, Michael R., DeLeon-Pennell, Kristine Y., Lindsey, Merry L.

“…Cardiac fibroblasts are the major producers of extracellular matrix (ECM) to form infarct scar. We hypothesized that fibroblasts undergo a spectrum of…”
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Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI) by Gaspar, António, Lourenço, André P., Pereira, Miguel Álvares, Azevedo, Pedro, Roncon-Albuquerque, Roberto, Marques, Jorge, Leite-Moreira, Adelino F.

“…To test whether remote ischaemic conditioning (RIC) as adjuvant to standard of care (SOC) would prevent progression towards heart failure (HF) after…”
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Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis by Liu, Xiaoxiao, Li, Minghui, Chen, Zhiwei, Yu, Yong, Shi, Hui, Yu, Ying, Wang, Yucheng, Chen, Ruizhen, Ge, Junbo

“…Treatment options for myocarditis are currently limited. Inhibition of calpains has been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries,…”
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