Search Results - "Basbaum, C. B."

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells by SOMMERHOFF, C. P, NADEL, J. A, BASBAUM, C. B, CAUGHEY, G. H

“…To investigate the hypothesis that neutrophil proteases stimulate airway gland secretion, we studied the effect of human cathepsin G and elastase on secretion…”
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Persistent mucin glycoprotein alterations in equine recurrent airway obstruction by Jefcoat, A M, Hotchkiss, J A, Gerber, V, Harkema, J R, Basbaum, C B, Robinson, N E

“…Horses with the episodic asthmalike condition of recurrent airway obstruction (RAO) have bouts of inflammation and bronchoconstriction associated with indoor…”
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Lung Mucin Production Is Stimulated by the Air Pollutant Residual Oil Fly Ash by Longphre, M., Li, D., Li, J., Matovinovic, E., Gallup, M., Samet, J.M., Basbaum, C.B.

“…Human and animal exposure to particulate air pollution is correlated with airway mucus hypersecretion and increased susceptibility to infection. Seeking clues…”
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Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer by Chang, S K, Dohrman, A F, Basbaum, C B, Ho, S B, Tsuda, T, Toribara, N W, Gum, J R, Kim, Y S

“…Several studies have reported Northern blot data showing that mucin is expressed in a tissue-specific manner. To determine whether expression is limited to…”
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Characterization of Human Tracheal Epithelial Cells Transformed by an Origin-Defective Simian Virus 40 by Gruenert, D. C., Basbaum, C. B., Welsh, M. J., Li, M., Finkbeiner, W. E., Nadel, J. A.

“…To facilitate understanding of the mechanisms underlying pulmonary diseases, including lung cancer and cystic fibrosis, we have transformed and characterized…”
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Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea by Sekizawa, K, Tamaoki, J, Graf, P D, Basbaum, C B, Borson, D B, Nadel, J A

“…To determine the roles of endogenous enkephalinase (EC.3.4.24.11) in regulating tachykinin-induced contraction of airway smooth muscle, the authors studied the…”
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Altered mucin expression is a field change that accompanies mucinous (colloid) breast carcinoma histogenesis by O'Connell, Jerome T, Shao, Zhi-Ming, Drori, Ehud, Basbaum, Carol B, Barsky, Sanford H

“…Mucinous carcinomas of the breast, so-called colloid carcinomas, exhibit better prognoses than their nonmucinous breast counterparts. This biological…”
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Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway by H Ohmori, A F Dohrman, M Gallup, T Tsuda, H Kai, J R Gum, Jr, Y S Kim, C B Basbaum

“…To obtain cDNAs for analysis of mucin gene transcription in rat models of human disease, we screened a rat intestinal cDNA library in lambda ZAPII using an…”
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Mast cell chymase. A potent secretagogue for airway gland serous cells by Sommerhoff, CP, Caughey, GH, Finkbeiner, WE, Lazarus, SC, Basbaum, CB, Nadel, JA

“…Submucosal glands are the major sources of airway secretions in most mammals. Mast cells are abundant in the environment of airway submucosal glands and are…”
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Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2–TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB signaling pathways by Chen, Ran, Lim, Jae Hyang, Jono, Hirofumi, Gu, Xin-Xing, Kim, Young S., Basbaum, Carol B., Murphy, Timothy F., Li, Jian-Dong

“…Mucin overproduction is a hallmark of nontypeable Haemophilus influenzae (NTHi) infections. The molecular mechanisms underlying up-regulation of mucin in NTHi…”
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The serous cell by BASBAUM, C. B, JANY, B, FINKBEINER, W. E

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Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface by Basbaum, Carol B, Werb, Zena

“…Cells respond to changes in their microenvironment by altering their cell surface and extracellular matrix proteins. Rapid and irreversible changes in these…”
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Human bronchus and intestine express the same mucin gene by JANY, B. H, GALLUP, M. W, PEI-SHA YAN, GUM, J. R, KIM, Y. S, BASBAUM, C. B

“…The amino acid and sugar composition of mucins from various organs is similar but not identical. This could arise by one or more of the following:…”
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Novel Cytoplasmic Proteins of Nontypeable Haemophilus influenzae Up-regulate Human MUC5AC Mucin Transcription via a Positive p38 Mitogen-activated Protein Kinase Pathway and a Negative Phosphoinositide 3-Kinase-Akt Pathway by Wang, Beinan, Lim, David J, Han, Jiahuai, Kim, Young S, Basbaum, Carol B, Li, Jian-Dong

“…Nontypeable Haemophilus influenzae (NTHi) is an important human pathogen that causes chronic otitis media with effusion (COME) in children and exacerbation of…”
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Monoclonal antibodies directed against human airway secretions. Localization and characterization of antigens by Finkbeiner, WE, Basbaum, CB

“…Cellular mechanisms of normal airway mucus secretion and their alterations in chronic obstructive lung disease are poorly understood. To aid in their study,…”
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Neuropeptides degranulate serous cells of ferret tracheal glands by Gashi, A A, Borson, D B, Finkbeiner, W E, Nadel, J A, Basbaum, C B

“…To determine whether serous or mucous cells in tracheal submucosal glands respond to the neuropeptides substance P (SP) and vasoactive intestinal peptide…”
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Transcriptional Activation of Mucin by Pseudomonas aeruginosa Lipopolysaccharide in the Pathogenesis of Cystic Fibrosis Lung Disease by Li, Jian-Dong, Dohrman, Austin F., Gallup, Marianne, Miyata, Susumu, Gum, James R., Kim, Young S., Nadel, Jay A., Prince, Alice, Basbaum, Carol B.

“…An unresolved question in cystic fibrosis (CF) research is how mutations of the CF transmembrane conductance regulator, a CI ion channel, cause airway mucus…”
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Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts by Li, D, Gallup, M, Fan, N, Szymkowski, D E, Basbaum, C B

“…To obtain gene regulatory sequence for the mucin gene MUC5AC, we have isolated the MUC5AC amino terminus cDNA and 5'-flanking region. This was possible through…”
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cAMP immunocytochemistry provides evidence for functional VIP receptors in trachea by Lazarus, S C, Basbaum, C B, Barnes, P J, Gold, W M

“…Vasoactive intestinal peptide (VIP), first isolated from porcine intestine (S. I. Said and V. Mutt, Science Wash. DC 169: 1217-1218, 1970), has been identified…”
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Glycoconjugates secreted by bovine tracheal serous cells in culture by Paul, A, Picard, J, Mergey, M, Veissiere, D, Finkbeiner, W E, Basbaum, C B

“…Glycoconjugates secreted by bovine tracheal gland serous cells in culture were characterized after incorporation of radioactive precursor [1-14C]glucosamine…”
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