Molecular epidemiology and clinical characteristics of epidermal growth factor receptor mutations in NSCLC: A single-center experience from India

Molecular epidemiology and clinical characteristics of epidermal growth factor receptor mutations in NSCLC: A single-center experience from India

Background: The genetic profiling of non-small cell lung cancer (NSCLC) has contributed to the discovery of actionable targetable mutations, which have significantly improved outcomes in disease with poor prognosis. Molecular epidemiological data of driver mutations in Indian populations have not be...

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Published in:Journal of cancer research and therapeutics Vol. 19; no. 5; pp. 1398 - 1406
Main Authors: Thomas, Renjan, Balaram, Gautam, Varayathu, Hrish, Ghorpade, Suhas, Kowsik, Prarthana, Dharman, Baby, Thomas, Beulah, Ramaswamy, Veena, Nanjaiah, Tejaswini, Patil, Shekar, Naik, Radheysham, Basavalinga, Ajai, Ghosh, Mithua
Format: Journal Article
Language:English
Published: Mumbai Wolters Kluwer India Pvt. Ltd 01-07-2023
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Subjects:
Cancer
Care and treatment
Epidemiology
Epidermal growth factor
Gene mutations
Genetic aspects
Lung cancer
Lung cancer, Non-small cell
Medical prognosis
Mutation
Oncology, Experimental
Patient outcomes
Prognosis
India
T790M
EGFR double mutations
EGFR uncommon mutations
EGFR common mutations
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Summary:Background: The genetic profiling of non-small cell lung cancer (NSCLC) has contributed to the discovery of actionable targetable mutations, which have significantly improved outcomes in disease with poor prognosis. Molecular epidemiological data of driver mutations in Indian populations have not been extensively elaborated compared to western and eastern Asian NSCLC populations. This study assessed the prevalence and clinical outcomes of EGFR (epidermal growth factor receptor) mutations among the Indian NSCLC cohort in South India. Patients and Methods: Retrospective analysis of 2,003 NSCLC patients who had undergone EGFR mutational analysis from 2013 to 2020 was performed. Clinical analysis was performed for 141 patients from 2013 to 2017 using Kaplan-Meier and Chi-square methods. Descriptive and survival statistics were performed using IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp. Results: EGFR-sensitizing mutations were detected in 41.6% (834/2003) in the study cohort with compound mutations detected in 7.55% (63/834) of EGFR-positive cases. A significant relationship with regard to female gender and EGFR mutation status (P <.001) was observed. Exon 18 G719X (8.7%) mutations and exon 20 T790M point mutation (3.1%) were the most frequently isolated uncommon EGFR mutations. In the clinical cohort, EGFR mutations were detected at a significantly higher prevalence in females (P =0.002) and never-smokers (P < 0.001). EGFR mutation demonstrated a significant relationship with regard to brain metastasis (P = 0.011). EGFR mutated individuals had significantly longer median overall survival compared to EGFR wild type (26 months vs. 12 months, P = 0.044). Conclusion: We reports the highest number of EGFR mutation analysis performed from India and mutational analysis indicated a loco-regional variation in India with regard to EGFR mutation frequency and its subtypes.
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ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.jcrt_1986_21