Search Results - "Basappa, Basappa"

Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells by Vishwanath, Divakar, Xi, Zhang, Ravish, Akshay, Mohan, Arunkumar, Basappa, Shreeja, Krishnamurthy, Niranjan Pattehalli, Gaonkar, Santosh L, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Histone deacetylases (HDACs) are an attractive drug target for the treatment of human breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being…”
Get full text

Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells by Kim, Na Young, Vishwanath, Divakar, Xi, Zhang, Nagaraja, Omantheswara, Swamynayaka, Ananda, Kumar Harish, Keshav, Basappa, Shreeja, Madegowda, Mahendra, Pandey, Vijay, Sethi, Gautam, Lobie, Peter E, Ahn, Kwang Seok, Basappa, Basappa

“…Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a…”
Get full text

Sintering Mechanisms of High-Performance Garnet-type Solid Electrolyte Densified by Spark Plasma Sintering by Yamada, Hirotoshi, Ito, Tomoko, Hongahally Basappa, Rajendra

“…•Impurity formation mechanisms are studied on SPS of garnet-type solid electrolytes.•Electrolysis produces La2Zr2O7 on anode and amorphous carbon on…”
Get full text

Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells by Kim, Na Young, Dukanya, Dukanya, Sethi, Gautam, Girimanchanaika, Swamy S, Yang, Jirui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Vishwanath, Divakar, Venkantesha, Keerthikumara, Basappa, Shreeja, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Madegowda, Mahendra, Sukhorukov, Alexey, Pandey, Vijay, Lobie, Peter E., Basappa, Basappa, Ahn, Kwang Seok

“…•To overcome drug-resistant breast cancer, it is essential to develop compounds that induce apoptosis and paraptosis.•BSO-07 triggered G1 phase arrest, cleaved…”
Get full text

Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells by Basappa, Basappa, Chumadathil Pookunoth, Baburajeev, Shinduvalli Kempasiddegowda, Mamatha, Knchugarakoppal Subbegowda, Rangappa, Lobie, Peter E, Pandey, Vijay

“…Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as oestrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor…”
Get full text

Electrochemical Synthesis of Versatile Pyrimidine and Oxadiazoles Tethered Triazoles as Inhibitors of VEGFR-2 in Human Breast Cancer Cells by Akshay Ravish, Tejaswini P. Siddappa, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Shreeja Basappa, Niranjan Pattehalli Krishnamurthy, Peter E. Lobie, Vijay Pandey, Basappa Basappa

“…Metastasis, the dissemination of tumor cells, stands as the second most prominent contributor to mortality arising from breast cancer. To counteract this…”
Get full text

Development of an Environment-Friendly and Electrochemical Method for the Synthesis of an Oxadiazole Drug-Scaffold That Targets Poly(ADP-Ribose)Polymerase in Human Breast Cancer Cells by Sindhu M. Parameshwaraiah, Zhang Xi, Akshay Ravish, Arunkumar Mohan, Vanishree Shankarnaik, Dukanya Dukanya, Shreeja Basappa, Habbanakuppe D. Preetham, Ganga Periyasamy, Santhosh L. Gaonkar, Peter E. Lobie, Vijay Pandey, Basappa Basappa

“…The development of environment-friendly new Poly-adenosine diphosphate (ADP)-ribose Polymerase (PARP) inhibitors are highly essential because of their…”
Get full text

Line segment disk cover by Basappa, Manjanna

“…In this paper, we consider the following variations of the Line Segment Disk Cover (LSDC) problem. LSDC-H: In this version of LSDC problem, we are given a set…”
Get full text

Grain boundary modification to suppress lithium penetration through garnet-type solid electrolyte by Hongahally Basappa, Rajendra, Ito, Tomoko, Morimura, Takao, Bekarevich, Raman, Mitsuishi, Kazutaka, Yamada, Hirotoshi

“…Garnet-type solid electrolytes are one of key materials to enable practical usage of lithium metal anode for high-energy-density batteries. However, it suffers…”
Get full text

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase by Vishwanath, Divakar, Girimanchanaika, Swamy S, Dukanya, Dukanya, Rangappa, Shobith, Yang, Ji-Rui, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1…”
Get full text

Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma by Zhang, Xi, Huang, Peng, Wang, Liqiong, Chen, Shu, Basappa, Basappa, Zhu, Tao, Lobie, Peter E., Pandey, Vijay

“…Loss of phosphatase and tensin homolog (PTEN) impairs DNA double-strand repair and confers sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis)…”
Get full text

Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer by Wang, Liqiong, Zhang, Xi, Chen, Shu, Ye, Qiuhua, Basappa, Basappa, Zhu, Tao, Lobie, Peter E., Pandey, Vijay

“…•MMC treatment of cervical carcinoma (CC) cell lines stimulated phosphorylation of BAD at serine 99 (pBADS99) and the pBADS99/BAD ratio was positively…”
Get full text

Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer by Tan, Yan Qin, Chiou, Yi-Shiou, Guo, Hui, Zhang, Shuwei, Huang, Xiaoming, Dukanya, Dukanya, Kumar, Arun M., Basappa, Shreeja, Liu, Suling, Zhu, Tao, Basappa, Basappa, Pandey, Vijay, Lobie, Peter E.

“…Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC…”
Get full text

Superchilling of muscle foods: Potential alternative for chilling and freezing by Banerjee, Rituparna, Maheswarappa, Naveena Basappa

“…Superchilling is an attractive technique for preservation of muscle foods which freezes part of the water and insulate the food products from temperature…”
Get full text

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation by Cao, Yu, Lu, Chang, Beeraka, Narasimha M, Efetov, Sergey, Enikeev, Mikhail, Fu, Yu, Yang, Xinyi, Basappa, Basappa, He, Mingze, Li, Zhi

“…Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer membrane…”
Get full text

Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression by Cheng, Feifei, Wang, Xuejuan, Chiou, Yi-Shiou, He, Chuyu, Guo, Hui, Tan, Yan Qin, Basappa, Basappa, Zhu, Tao, Pandey, Vijay, Lobie, Peter E.

“…Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with a dismal prognosis that has changed little over the past few decades…”
Get full text

Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma by Tan, Yan Qin, Sun, Bowen, Zhang, Xi, Zhang, Shuwei, Guo, Hui, Basappa, Basappa, Zhu, Tao, Sethi, Gautam, Lobie, Peter E., Pandey, Vijay

“…Therapeutic targeting of KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) has remained a significant challenge in clinical oncology. Direct targeting of…”
Get full text

Isoxazole based nucleosides induce autophagy through the production of ROS and the suppression of the β-catenin pathway in human colorectal carcinoma cells by Kim, Na Young, Vishwanath, Divakar, Basappa, Shreeja, Harish, Keshav Kumar, Madegowda, Mahendra, Rangappa, Kanchugarakoppal S., Basappa, Basappa, Ahn, Kwang Seok

“…β-catenin is frequently implicated in signaling pathways that regulate autophagy, and the production of reactive oxygen species (ROS) has been linked to…”
Get full text

Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β-catenin signaling pathway in human breast cancer cells by Yoon, Bada, Basappa, Basappa, Basappa, Shreeja, Nagaraju, Omantheswara, Madegowda, Mahendra, Rangappa, K S, Sethi, Gautam, Ahn, Kwang Seok

“…Autophagy is vital for maintaining cellular homeostasis by breaking down unnecessary organelles and proteins within cells. Its activity varies abnormally in…”
Get full text

Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells by Deveshegowda, Suresha N, Metri, Prashant K, Shivakumar, Rashmi, Yang, Ji-Rui, Rangappa, Shobith, Swamynayaka, Ananda, Shanmugam, Muthu K, Nagaraja, Omantheswara, Madegowda, Mahendra, Babu Shubha, Priya, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Ahn, Kwang Seok, Lobie, Peter E, Basappa, Basappa

“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
Get full text