Search Results - "Basáñez, Gorka"

Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1 by Bustillo-Zabalbeitia, Itsasne, Montessuit, Sylvie, Raemy, Etienne, Basañez, Gorka, Terrones, Oihana, Martinou, Jean-Claude

“…Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1…”
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Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size by Bleicken, Stephanie, Landeta, Olatz, Landajuela, Ane, Basañez, Gorka, García-Sáez, Ana J.

“…The Bcl-2 proapoptotic proteins Bax and Bak mediate the permeabilization of the mitochondrial outer membrane during apoptosis. Current models consider that Bax…”
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Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation by Flores-Romero, Hector, Garcia-Porras, Miguel, Basañez, Gorka

“…Despite intensive research effort, how the paradigmatic proapoptotic protein BAX forms lethal apoptotic pores at the mitochondrial outer membrane (MOM) remains…”
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BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL by Flores-Romero, Hector, Landeta, Olatz, Ugarte-Uribe, Begoña, Cosentino, Katia, García-Porras, Miguel, García-Sáez, Ana J., Basañez, Gorka

“…BFL1 is a relatively understudied member of the BCL2 protein family which has been implicated in the pathogenesis and chemoresistance of a variety of human…”
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Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria by Polster, Brian M., Basañez, Gorka, Etxebarria, Aitor, Hardwick, J. Marie, Nicholls, David G.

“…The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has been implicated in the mechanism of glutamate excitotoxicity in…”
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Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization by Montessuit, Sylvie, Somasekharan, Syam Prakash, Terrones, Oihana, Lucken-Ardjomande, Safa, Herzig, Sébastien, Schwarzenbacher, Robert, Manstein, Dietmar J., Bossy-Wetzel, Ella, Basañez, Gorka, Meda, Paolo, Martinou, Jean-Claude

“…In response to many apoptotic stimuli, oligomerization of Bax is essential for mitochondrial outer membrane permeabilization and the ensuing release of…”
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Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma by MONTERO, Joan, MORALES, Albert, FERNANDEZ-CHECA, José C, LLACUNA, Laura, LLUIS, Josep M, TERRONES, Oihana, BASANEZ, Gorka, ANTONSSON, Bruno, PRIETO, Jesus, GARCIA-RUIZ, Carmen, COLELL, Anna

“…Cholesterol metabolism is deregulated in carcinogenesis, and cancer cells exhibit enhanced mitochondrial cholesterol content whose role in cell death…”
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A new view of the lethal apoptotic pore by Basañez, Gorka, Soane, Lucian, Hardwick, J Marie

“…Cell death by apoptosis is indispensable for proper development and tissue homeostasis in all multicellular organisms, and its deregulation plays a key role in…”
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Liposomes Decorated with Apo2L/TRAIL Overcome Chemoresistance of Human Hematologic Tumor Cells by De Miguel, Diego, Basáñez, Gorka, Sánchez, Diego, Malo, Patricia Galán, Marzo, Isabel, Larrad, Luis, Naval, Javier, Pardo, Julián, Anel, Alberto, Martinez-Lostao, Luis

“…Human Apo2-ligand/TRAIL is a member of the TNF cytokine superfamily capable of inducing apoptosis on tumor cells while sparing normal cells. Besides its…”
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The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading by Baulies, Anna, Montero, Joan, Matías, Nuria, Insausti, Naroa, Terrones, Oihana, Basañez, Gorka, Vallejo, Carmen, Conde de La Rosa, Laura, Martinez, Laura, Robles, David, Morales, Albert, Abian, Joaquin, Carrascal, Montserrat, Machida, Keigo, Kumar, Dinesh B.U., Tsukamoto, Hidekazu, Kaplowitz, Neil, Garcia-Ruiz, Carmen, Fernández-Checa, José C.

“…Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer…”
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Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK by Landeta, Olatz, Landajuela, Ane, Garcia-Saez, Ana, Basañez, Gorka

“…Proteins belonging to the BCL2 family are key modulators of apoptosis that establish a complex network of interactions among themselves and with other cellular…”
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Different Effects of Enzyme-generated Ceramides and Diacylglycerols in Phospholipid Membrane Fusion and Leakage by M. Begoña Ruiz-Argüello, Gorka Basáñez, Félix M. Goñi, Alicia Alonso

“…When large unilamellar vesicles consisting of sphingomyelin:phosphatidylethanolamine:cholesterol (2:1:1 molar ratio) are treated with sphingomyelinase,…”
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Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death by Montero, Joan, Mari, Montserrat, Colell, Anna, Morales, Albert, Basañez, Gorka, Garcia-Ruiz, Carmen, Fernández-Checa, Jose C.

“…Mitochondria are known to actively regulate cell death with the final phenotype of demise being determined by the metabolic and energetic status of the cell…”
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Mitochondrial fission proteins regulate programmed cell death in yeast by Fannjiang, Yihru, Cheng, Wen-Chih, Lee, Sarah J, Qi, Bing, Pevsner, Jonathan, McCaffery, J Michael, Hill, R Blake, Basañez, Gorka, Hardwick, J Marie

“…The possibility that single-cell organisms undergo programmed cell death has been questioned in part because they lack several key components of the mammalian…”
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Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity by Orzáez, Mar, Sancho, Mónica, Marchán, Sandra, Mondragón, Laura, Montava, Rebeca, Valero, Juan García, Landeta, Olatz, Basañez, Gorka, Carbajo, Rodrigo J, Pineda-Lucena, Antonio, Bujons, Jordi, Moure, Alejandra, Messeguer, Angel, Lagunas, Carmen, Herrero, Carmen, Pérez-Payá, Enrique

“…Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially…”
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Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process by Landeta, Olatz, Landajuela, Ane, Gil, David, Taneva, Stefka, DiPrimo, Carmelo, Sot, Begoña, Valle, Mikel, Frolov, Vadim A., Basañez, Gorka

“…BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose molecular mechanism of action remains to be fully dissected in intact…”
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Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems by Etxebarria, Aitor, Landeta, Olatz, Antonsson, Bruno, Basañez, Gorka

“…Small-molecule drugs that induce apoptosis in tumor cells by activation of the BCL-2-regulated mitochondrial outer membrane permeabilization (MOMP) pathway…”
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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3 by Hockenbery, David M, Tzung, Shie-Pon, Kim, Kristine M, Basañez, Gorka, Giedt, Chris D, Simon, Julian, Zimmerberg, Joshua, Zhang, Kam Y. J

“…The Bcl-2-related survival proteins confer cellular resistance to a wide range of agents. Bcl-xL-expressing hepatocyte cell lines are resistant to tumour…”
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Asymmetric Addition of Ceramides but not Dihydroceramides Promotes Transbilayer (Flip-Flop) Lipid Motion in Membranes by Contreras, F.-Xabier, Basañez, Gorka, Alonso, Alicia, Herrmann, Andreas, Goñi, Félix M.

“…Transbilayer lipid motion in membranes may be important in certain physiological events, such as ceramide signaling. In this study, the transbilayer…”
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Lipid-Dependent Bimodal MCL1 Membrane Activity by Landeta, Olatz, Valero, Juan Garcia, Flores-Romero, Hector, Bustillo-Zabalbeitia, Itsasne, Landajuela, Ane, Garcia-Porras, Miguel, Terrones, Oihana, Basañez, Gorka

“…Increasing evidence indicates that the mitochondrial lipid membrane environment directly modulates the BCL2 family protein function, but the underlying…”
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