Search Results - "Barzak, Fareeda M"

Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity by Barzak, Fareeda M, Ryan, Timothy M, Mohammadzadeh, Nazanin, Harjes, Stefan, Kvach, Maksim V, Kurup, Harikrishnan M, Krause, Kurt L, Chelico, Linda, Filichev, Vyacheslav V, Harjes, Elena, Jameson, Geoffrey B

“…APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response…”
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Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor by Barzak, Fareeda M, Ryan, Timothy M, Kvach, Maksim V, Kurup, Harikrishnan M, Aihara, Hideki, Harris, Reuben S, Filichev, Vyacheslav V, Harjes, Elena, Jameson, Geoffrey B

“…In normal cells APOBEC3 (A3A-A3H) enzymes as part of the innate immune system deaminate cytosine to uracil on single-stranded DNA (ssDNA) to scramble DNA in…”
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Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation by Middleton, Adam J., Barzak, Fareeda M., Fokkens, Thornton J., Nguyen, Khanh, Day, Catherine L.

“…Inflammation is essential for healthy immune function, wound healing, and resolution of infection. RIG-I is a key RNA sensor that initiates an immune response,…”
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Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A by Kurup, Harikrishnan M., Kvach, Maksim V., Harjes, Stefan, Barzak, Fareeda M., Jameson, Geoffrey B., Harjes, Elena, Filichev, Vyacheslav V.

“…Drug resistance is a major problem associated with anticancer chemo- and immunotherapies. Recent advances in the understanding of resistance mechanisms have…”
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Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine by Barzak, Fareeda M, Harjes, Stefan, Kvach, Maksim V, Kurup, Harikrishnan M, Jameson, Geoffrey B, Filichev, Vyacheslav V, Harjes, Elena

“…To restrict pathogens, in a normal human cell, APOBEC3 enzymes mutate cytosine to uracil in foreign single-stranded DNAs. However, in cancer cells, APOBEC3B…”
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A novel RNF125 variant associated with Tenorio syndrome alters ubiquitin chain binding by Barzak, Fareeda M., Lu, Anita, Geltzeiler, Alexa R., Ledgerwood, Elizabeth C., Chung, Wendy K., Day, Catherine L.

“…A key signalling pathway required for clearance of viruses from host cells relies on the receptor protein, retinoic acid‐inducible gene I (RIG‐I). The activity…”
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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues by Kvach, Maksim V, Barzak, Fareeda M, Harjes, Stefan, Schares, Henry A. M, Jameson, Geoffrey B, Ayoub, Alex M, Moorthy, Ramkumar, Aihara, Hideki, Harris, Reuben S, Filichev, Vyacheslav V, Harki, Daniel A, Harjes, Elena

“…APOBEC3 enzymes form part of the innate immune system by deaminating cytosine to uracil in single-stranded DNA (ssDNA) and thereby preventing the spread of…”
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Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA by Kvach, Maksim V., Barzak, Fareeda M., Harjes, Stefan, Schares, Henry A. M., Kurup, Harikrishnan M., Jones, Katherine F., Sutton, Lorraine, Donahue, John, D'Aquila, Richard T., Jameson, Geoffrey B., Harki, Daniel A., Krause, Kurt L., Harjes, Elena, Filichev, Vyacheslav V.

“…The APOBEC3 (APOBEC3A‐H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single‐stranded (ss) DNA by…”
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