Search Results - "Barykin, Evgeny P."

Synthetic, Cell-Derived, Brain-Derived, and Recombinant β-Amyloid: Modelling Alzheimer's Disease for Research and Drug Development by Varshavskaya, Kseniya B, Mitkevich, Vladimir A, Makarov, Alexander A, Barykin, Evgeny P

“…Alzheimer's disease (AD) is the most common cause of dementia in the elderly, characterised by the accumulation of senile plaques and tau tangles,…”
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Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease? by Barykin, Evgeny P, Mitkevich, Vladimir A, Kozin, Sergey A, Makarov, Alexander A

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Distinct Effects of Beta-Amyloid, Its Isomerized and Phosphorylated Forms on the Redox Status and Mitochondrial Functioning of the Blood-Brain Barrier Endothelium by Petrovskaya, Aleksandra V, Tverskoi, Artem M, Barykin, Evgeny P, Varshavskaya, Kseniya B, Dalina, Alexandra A, Mitkevich, Vladimir A, Makarov, Alexander A, Petrushanko, Irina Yu

“…The Alzheimer's disease (AD)-associated breakdown of the blood-brain barrier (BBB) promotes the accumulation of beta-amyloid peptide (Aβ) in the brain as the…”
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Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model by Varshavskaya, Kseniya B, Petrushanko, Irina Yu, Mitkevich, Vladimir A, Barykin, Evgeny P, Makarov, Alexander A

“…One of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation of soluble neurotoxic Aβ oligomers and…”
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Tetrapeptide Ac-HAEE-NH2 Protects α4β2 nAChR from Inhibition by Aβ by Barykin, Evgeny P., Garifulina, Aleksandra I., Tolstova, Anna P., Anashkina, Anastasia A., Adzhubei, Alexei A., Mezentsev, Yuri V., Shelukhina, Irina V., Kozin, Sergey A., Tsetlin, Victor I., Makarov, Alexander A.

“…The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic…”
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The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer's Disease by Bugrova, Anna E, Strelnikova, Polina A, Indeykina, Maria I, Kononikhin, Alexey S, Zakharova, Natalia V, Brzhozovskiy, Alexander G, Barykin, Evgeny P, Pekov, Stanislav I, Gavrish, Maria S, Babaev, Alexey A, Kosyreva, Anna M, Morozova, Anna Y, Degterev, Daniil A, Mitkevich, Vladimir A, Popov, Igor A, Makarov, Alexander A, Nikolaev, Evgeny N

“…Alzheimer's disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino…”
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Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition by Barykin, Evgeny P, Petrushanko, Irina Y, Kozin, Sergey A, Telegin, Georgy B, Chernov, Alexander S, Lopina, Olga D, Radko, Sergey P, Mitkevich, Vladimir A, Makarov, Alexander A

“…The triggers of late-onset sporadic Alzheimer's disease (AD) are still poorly understood. Impairment of protein phosphorylation with age is well-known;…”
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Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases by Barykin, Evgeny P, Yanvarev, Dmitry V, Strelkova, Maria A, Valuev-Elliston, Vladimir T, Varshavskaya, Kseniya B, Mitkevich, Vladimir A, Makarov, Alexander A

“…Phosphorylation of beta-amyloid peptide (Aβ) at the Ser8 residue affects its neurotoxicity, metal-dependent oligomerisation, amyloidogenicity, and other…”
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Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's Disease by Kozin, Sergey A, Barykin, Evgeny P, Telegin, Georgy B, Chernov, Alexander S, Adzhubei, Alexei A, Radko, Sergey P, Mitkevich, Vladimir A, Makarov, Alexander A

“…Cerebral β-amyloidosis, an accumulation in the patient's brain of aggregated amyloid-β (Aβ) peptides abnormally saturated by divalent biometal ions, is one of…”
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Na,K-ATPase Acts as a Beta-Amyloid Receptor Triggering Src Kinase Activation by Petrushanko, Irina Yu, Tverskoi, Artem M, Barykin, Evgeny P, Petrovskaya, Aleksandra V, Strelkova, Maria A, Leonova, Olga G, Anashkina, Anastasia A, Tolstova, Anna P, Adzhubei, Alexei A, Bogdanova, Anna Yu, Makarov, Alexander A, Mitkevich, Vladimir A

“…Beta-amyloid (Aβ) has a dual role, both as an important factor in the pathology of Alzheimer’s disease and as a regulator in brain physiology. The inhibitory…”
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Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity by Barykin, Evgeny P, Garifulina, Alexandra I, Kruykova, Elena V, Spirova, Ekaterina N, Anashkina, Anastasia A, Adzhubei, Alexei A, Shelukhina, Irina V, Kasheverov, Igor E, Mitkevich, Vladimir A, Kozin, Sergey A, Hollmann, Michael, Tsetlin, Victor I, Makarov, Alexander A

“…Cholinergic dysfunction in Alzheimer's disease (AD) can be mediated by the neuronal α7 nicotinic acetylcholine receptor (α7nAChR). Beta-amyloid peptide (Aβ)…”
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Snake Toxins Labeled by Green Fluorescent Protein or Its Synthetic Chromophore are New Probes for Nicotinic acetylcholine Receptors by Kasheverov, Igor E, Kuzmenkov, Alexey I, Kudryavtsev, Denis S, Chudetskiy, Ivan S, Shelukhina, Irina V, Barykin, Evgeny P, Ivanov, Igor A, Siniavin, Andrei E, Ziganshin, Rustam H, Baranov, Mikhail S, Tsetlin, Victor I, Vassilevski, Alexander A, Utkin, Yuri N

“…Fluorescence can be exploited to monitor intermolecular interactions in real time and at a resolution up to a single molecule. It is a method of choice to…”
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Scanning Ion-Conductance Microscopy for Studying β‑Amyloid Aggregate Formation on Living Cell Surfaces by Kolmogorov, Vasilii S., Erofeev, Alexander S., Barykin, Evgeny P., Timoshenko, Roman V., Lopatukhina, Elena V., Kozin, Sergey A., Gorbacheva, Lyubov R., Salikhov, Sergey V., Klyachko, Natalia L., Mitkevich, Vladimir A., Edwards, Christopher R. W., Korchev, Yuri E., Makarov, Alexander A., Gorelkin, Petr V.

“…β-Amyloid aggregation on living cell surfaces is described as responsible for the neurotoxicity associated with different neurodegenerative diseases. It is…”
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Post-translational modifications of beta-amyloid modulate its effect on cell mechanical properties and influence cytoskeletal signaling cascades by Varshavskaya, Kseniya B., Barykin, Evgeny P., Timoshenko, Roman V., Kolmogorov, Vasilii S., Erofeev, Alexander S., Gorelkin, Petr V., Mitkevich, Vladimir A., Makarov, Alexander A.

“…Post-translational modifications of beta-amyloid (Aβ) play an important role in the pathogenesis of Alzheimer’s disease (AD). Aβ modifications such as Ser8…”
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Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE by Mitkevich, Vladimir A, Barykin, Evgeny P, Eremina, Svetlana, Pani, Bibhusita, Katkova-Zhukotskaya, Olga, Polshakov, Vladimir I, Adzhubei, Alexei A, Kozin, Sergey A, Mironov, Alexander S, Makarov, Alexander A, Nudler, Evgeny

“…The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral amyloid plaques, the main components of which are the modified Aβ…”
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Zn-dependent [beta]-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE by Mitkevich, Vladimir A, Barykin, Evgeny P, Eremina, Svetlana, Pani, Bibhusita, Katkova-Zhukotskaya, Olga, Polshakov, Vladimir I, Adzhubei, Alexei A, Kozin, Sergey A, Mironov, Alexander S, Makarov, Alexander A, Nudler, Evgeny

“…The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral amyloid plaques, the main components of which are the modified…”
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Tetrapeptide Ac-HAEE-NH 2 Protects α4β2 nAChR from Inhibition by Aβ by Barykin, Evgeny P, Garifulina, Aleksandra I, Tolstova, Anna P, Anashkina, Anastasia A, Adzhubei, Alexei A, Mezentsev, Yuri V, Shelukhina, Irina V, Kozin, Sergey A, Tsetlin, Victor I, Makarov, Alexander A

“…The cholinergic deficit in Alzheimer's disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic…”
Get full text