Search Results - "Barwell, J."

Genomic medicine for the 21st century by Rahman, I, Barwell, J

“…Integrated datasets are already use in CanRisk modelling for familial breast and ovarian cancer algorithms,2 and also for ten-year cardiovascular risk…”
Get full text

Lifting the lid on GPCRs: the role of extracellular loops by Wheatley, M, Wootten, D, Conner, MT, Simms, J, Kendrick, R, Logan, RT, Poyner, DR, Barwell, J

“…GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by intracellular loops and extracellular loops (ECLs). Given their peripheral…”
Get full text

Genetic testing and screening of individuals at risk of NF2 by Evans, DG, Raymond, FL, Barwell, JG, Halliday, D

“…Evans DG, Raymond FL, Barwell JG, Halliday D. Genetic testing and screening of individuals at risk of NF2. Genetic testing and management of the at‐risk…”
Get full text

Combined local and systemic antibiotic delivery improves eradication of wound contamination: An animal experimental model of contaminated fracture by Rand, B C C, Penn-Barwell, J G, Wenke, J C

“…Systemic antibiotics reduce infection in open fractures. Local delivery of antibiotics can provide higher doses to wounds without toxic systemic effects. This…”
Get more information

Impact of abdominal aortic aneurysm screening on quality of life by Bath, M. F., Sidloff, D., Saratzis, A., Bown, M. J., Pathak, R., Brooks, M., Hayes, P., Imray, C., Quarmby, J., Choksy, S., Earnshaw, J. J., Shearman, C. P., Grocott, E., Rix, T., Chetter, I., Tennant, W., Libertiny, G., Sykes, T., Dayer, M., Pike, L., Pherwani, A., Nice, C., Browning, N., McCollum, C., Yusuf, S., Gannon, M., Barwell, J., Baker, S., Vallabhaneni, S. R., Davies, A.

“…Background Screening for abdominal aortic aneurysm (AAA) is known to reduce AAA‐related mortality; however, the psychological impact of population AAA…”
Get full text

Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology by Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L

“…Background and Purpose Receptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR). The interactions of…”
Get full text

Died of wounds: a mortality review by Keene, Damian Douglas, Penn-Barwell, J G, Wood, P R, Hunt, N, Delaney, R, Clasper, J, Russell, R J, Mahoney, P F

“…Combat casualty care is a complex system involving multiple clinicians, medical interventions and casualty transfers. Improving the performance of this system…”
Get more information

The burden of gunshot wounding of UK military personnel in Iraq and Afghanistan from 2003–14 by Stevenson, T., Carr, D.J., Penn-Barwell, J.G., Ringrose, T.J., Stapley, S.A.

“…Gunshot wounding (GSW) is the second most common mechanism of injury in warfare after explosive injury. The aim of this study was to define the clinical burden…”
Get full text

Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations by Pollard, P.J., Brière, J.J., Alam, N.A., Barwell, J., Barclay, E., Wortham, N.C., Hunt, T., Mitchell, M., Olpin, S., Moat, S.J., Hargreaves, I.P., Heales, S.J., Chung, Y.L., Griffiths, J.R., Dalgleish, A., McGrath, J.A., Gleeson, M.J., Hodgson, S.V., Poulsom, R., Rustin, P., Tomlinson, I.P.M.

“…The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour suppressors. Germline mutations…”
Get full text

Severe open tibial fractures in combat trauma: management and preliminary outcomes by Penn-Barwell, J G, Bennett, P M, Fries, C A, Kendrew, J M, Midwinter, M J, Rickard, R F

“…The aim of this study was to report the pattern of severe open diaphyseal tibial fractures sustained by military personnel, and their orthopaedic-plastic…”
Get more information

Report of a Delphi exercise to inform the design of a research programme on screening for thoracic aortic disease by Abbasciano, R G, Barwell, J, Sayers, R, Bown, M, Milewicz, D, Cooper, G, Mariscalco, G, Wheeldon, N, Fowler, C, Owens, G, Murphy, G J

“…To inform the design of a clinical trial of a targeted screening programme for relatives of individuals affected by thoracic aortic disease, we performed a…”
Get full text

The management and outcome of open fractures of the femur sustained on the battlefield over a ten-year period by Bennett, P M, Sargeant, I D, Myatt, R W, Penn-Barwell, J G

“…This is a retrospective study of survivors of recent conflicts with an open fracture of the femur. We analysed the records of 48 patients (48 fractures) and…”
Get full text

DEMOGRAPHICS AND INJURY PATTERNS OF ACUTE KNEE DISLOCATIONS IN THE UNITED KINGDOM by Aujula, R., Shaw, C., McMullan, M., Akhtar, A., Rooney, A., Wheelton, A., Wilding, C., Barwell, J., Spacey, K., Gokhale, N., Hashim, Z., Nabulyato, W., Godsiff, S.

Get full text

Unilateral lower limb loss following combat injury: medium-term outcomes in British military amputees by Bennett, P M, Sargeant, I D, Midwinter, M J, Penn-Barwell, J G

“…This is a case series of prospectively gathered data characterising the injuries, surgical treatment and outcomes of consecutive British service personnel who…”
Get more information

Military Health Systems Research Symposium 2015 by Penn-Barwell, J

Get more information

Medium-term outcomes following limb salvage for severe open tibia fracture are similar to trans-tibial amputation by Penn-Barwell, J.G, Myatt, R.W, Bennett, P.M, Sargeant, I.D

“…Abstract Extremity injuries define the surgical burden of recent conflicts. Current literature is inconclusive when assessing the merits of limb salvage over…”
Get full text

Acute bilateral leg amputation following combat injury in UK servicemen by Penn-Barwell, J.G, Bennett, P.M, Kay, A, Sargeant, I.D

“…Abstract Background This study aims to characterise the injuries and surgical management of British servicemen sustaining bilateral lower limb amputations…”
Get full text

Outcomes following limb salvage after combat hindfoot injury are inferior to delayed amputation at five years by Bennett, P M, Stevenson, T, Sargeant, I D, Mountain, A, Penn-Barwell, J G

“…The surgical challenge with severe hindfoot injuries is one of technical feasibility, and whether the limb can be salvaged. There is an additional question of…”
Get full text

Prospective randomised controlled trial of nanocrystalline silver dressing versus plain gauze as the initial post-debridement management of military wounds on wound microbiology and healing by Fries, C.A, Ayalew, Y, Penn-Barwell, J.G, Porter, K, Jeffery, S.L.A, Midwinter, M.J

“…Abstract Introduction Recent conflicts have been characterised by the use of improvised explosive devices causing devastating injuries, including heavily…”
Get full text

Developing and assessing the utility of a You-Tube based clinical genetics video channel for families affected by inherited tumours by Jones, G. E., Singletary, J. H., Cashmore, A., Jain, V., Abhulimhen, J., Chauhan, J., Musson, H. V., Barwell, J. G.

“…We have designed and implemented the first worldwide You Tube channel with 22 videos covering common questions asked in familial cancer susceptibility clinics…”
Get full text