Search Results - "Bartz, Rene"

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease by Singh, Saurav, Grabner, Alexander, Yanucil, Christopher, Schramm, Karla, Czaya, Brian, Krick, Stefanie, Czaja, Mark J, Bartz, Rene, Abraham, Reimar, Di Marco, Giovana S, Brand, Marcus, Wolf, Myles, Faul, Christian

“…Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-regulating hormone, fibroblast growth factor (FGF) 23, that are associated…”
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Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME) by Bretz, Anne Catherine, Parnitzke, Ulrike, Kronthaler, Kerstin, Dreker, Tobias, Bartz, René, Hermann, Frank, Ammendola, Astrid, Wulff, Tanja, Hamm, Svetlana

“…BackgroundThe efficacy of PD-(L)1 blockade depends on the composition of the tumor immune microenvironment (TIME) and is generally higher in tumors with…”
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Phase I study of domatinostat (4SC‐202), a class I histone deacetylase inhibitor in patients with advanced hematological malignancies by Tresckow, Bastian, Sayehli, Cyrus, Aulitzky, Walter E., Goebeler, Maria‐Elisabeth, Schwab, Matthias, Braz, Eunice, Krauss, Babett, Krauss, Rolf, Hermann, Frank, Bartz, René, Engert, Andreas

“…Objectives Domatinostat (4SC‐202) is a selective class I histone deacetylase inhibitor (HDACi). This phase I study investigated safety, tolerability,…”
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Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic by Bartz, René, Li, Wen-Hong, Venables, Barney, Zehmer, John K, Roth, Mary R, Welti, Ruth, Anderson, Richard G.W, Liu, Pingsheng, Chapman, Kent D

“…Lipid droplets are accumulations of neutral lipids surrounded by a monolayer of phospholipids and associated proteins. Recent proteomic analysis of isolated…”
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Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity by Bartz, René, Fukuchi, Keisuke, Ohtsuka, Toshiaki, Lange, Tanja, Gruner, Katrin, Watanabe, Ichiro, Hayashi, Shinko, Oda, Yoko, Kawaida, Reimi, Komori, Hironobu, Kashimoto, Yoshinori, Wirtz, Peter, Mayer, Jan-Peter A, Redondo-Müller, Mauricio, Saito, Shuntaro, Takahashi, Mizuki, Hanzawa, Hiroyuki, Imai, Emi, Martinez, Alberto, Hanai, Masaharu, Häussinger, Dieter, Chapman, Roger W, Agatsuma, Toshinori, Bange, Johannes, Abraham, Reimar

“…The FGFR4/FGF19 signaling axis is overactivated in 20% of liver tumors and currently represents a promising targetable signaling mechanism in this cancer type…”
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Rab-regulated interaction of early endosomes with lipid droplets by Liu, Pingsheng, Bartz, René, Zehmer, John K., Ying, Yun-shu, Zhu, Meifang, Serrero, Ginette, Anderson, Richard G.W.

“…Recent studies indicate that lipid droplets isolated from a variety of different cells are rich in proteins known to regulate membrane traffic. Among these…”
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Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA by Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.

“…Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and…”
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Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER by Bartz, René, Seemann, Joachim

“…The highly organized structure of the Golgi apparatus becomes compromised during mitosis. The Golgi cisternae unstack and form vesicles, which are then…”
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Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation by Bartz, René, Sun, Li-Ping, Bisel, Blaine, Wei, Jen-Hsuan, Seemann, Joachim

“…Sterol regulatory element‐binding proteins (SREBPs) are membrane‐bound transcription factors that reside as inactive precursors in the endoplasmic reticulum…”
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Caveolin‐1 secreting LNCaP cells induce tumor growth of caveolin‐1 negative LNCaP cells in vivo by Bartz, René, Zhou, Jian, Hsieh, Jer‐Tsong, Ying, Yunshu, Li, Weiping, Liu, Pingsheng

“…Caveolin‐1 (Cav‐1) was originally identified as a structural protein of caveolae, which is a plasma membrane domain that regulates a variety of signaling…”
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Functional characterization of human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 9: cloning, tissue distribution, gene structure, and enzymatic activity by Agarwal, Anil K, Sukumaran, Suja, Bartz, Rene, Barnes, Robert I, Garg, Abhimanyu

“…Most cells synthesize their glycerophospholipids and triglycerides (TG) to maintain the cellular integrity and to provide energy for cellular functions. The…”
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Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage by Bartz, René, Seemann, Joachim, Zehmer, John K, Serrero, Ginette, Chapman, Kent D, Anderson, Richard G W, Liu, Pingsheng

“…Mono-ADP-ribosylation is emerging as an important posttranslational modification that modulates a variety of cell signaling pathways. Here, we present evidence…”
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Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance by Gruber, Wolfgang, Peer, Elisabeth, Elmer, Dominik P., Sternberg, Christina, Tesanovic, Suzana, del Burgo, Pedro, Coni, Sonia, Canettieri, Gianluca, Neureiter, Daniel, Bartz, René, Kohlhof, Hella, Vitt, Daniel, Aberger, Fritz

“…Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and…”
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lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology by Szymanski, Kimberly M, Binns, Derk, Bartz, René, Grishin, Nick V, Li, Wei-Ping, Agarwal, Anil K, Garg, Abhimanyu, Anderson, Richard G.W, Goodman, Joel M

“…Lipodystrophy is a disorder characterized by a loss of adipose tissue often accompanied by severe hypertriglyceridemia, insulin resistance, diabetes, and fatty…”
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Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells by Wobser, Marion, Weber, Alexandra, Glunz, Amelie, Tauch, Saskia, Seitz, Kristina, Butelmann, Tobias, Hesbacher, Sonja, Goebeler, Matthias, Bartz, René, Kohlhof, Hella, Schrama, David, Houben, Roland

“…Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach…”
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Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets by Zehmer, John K, Bartz, René, Bisel, Blaine, Liu, Pingsheng, Seemann, Joachim, Anderson, Richard G.W

“…Lipid droplets are sites of neutral lipid storage thought to be actively involved in lipid homeostasis. A popular model proposes that droplets are formed in…”
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Dynamic Activity of Lipid Droplets:  Protein Phosphorylation and GTP-Mediated Protein Translocation by Bartz, René, Zehmer, John K, Zhu, Meifang, Chen, Yue, Serrero, Ginette, Zhao, Yingming, Liu, Pingsheng

“…Lipid droplet is a cellular organelle with a neutral lipid core surrounded by a phospholipid monolayer and coated with structural as well as functional…”
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Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets by Zehmer, John K, Bartz, René, Liu, Pingsheng, Anderson, Richard G.W

“…AAM-B is a putative methyltransferase that is a resident protein of lipid droplets. We have identified an N-terminal 28 amino acid hydrophobic sequence that is…”
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Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation by Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M, DeGrado, William F

“…There are many opportunities to use macromolecules, such as peptides and oligonucleotides, for intracellular applications. Despite this, general methods for…”
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Rab-regulated membrane traffic between adiposomes and multiple endomembrane systems by Liu, Pingsheng, Bartz, René, Zehmer, John K, Ying, Yunshu, Anderson, Richard G W

“…Lipid droplets play a critical role in a variety of metabolic diseases. Numerous proteomic studies have provided detailed information about the protein…”
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