Search Results - "Bartsch, Helmut"

Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair by Bartsch, Helmut, Nair, Jagadeesan

“…Chronic inflammation, induced by biological, chemical, and physical factors, was associated with increased risk of human cancer at various sites. Chronic…”
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Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: A review of published adduct types and levels in humans by Nair, Urmila, Bartsch, Helmut, Nair, Jagadeesan

“…Persistent oxidative stress and excess lipid peroxidation (LPO), induced by inflammatory processes, impaired metal storage, and/or dietary imbalance, cause…”
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The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts by Linhart, Kirsten, Bartsch, Helmut, Seitz, Helmut K

“…Exocyclic etheno-DNA adducts are mutagenic and carcinogenic and are formed by the reaction of lipidperoxidation (LPO) products such as 4-hydoxynonenal or…”
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Ethanol‐induced cytochrome P4502E1 causes carcinogenic etheno‐DNA lesions in alcoholic liver disease by Wang, Ying, Millonig, Gunda, Nair, Jagadeesan, Patsenker, Eleonora, Stickel, Felix, Mueller, Sebastian, Bartsch, Helmut, Seitz, Helmut K.

“…Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), a frequent complication of alcoholic liver disease (ALD)…”
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Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention by Bertl, Elisabeth, Bartsch, Helmut, Gerhäuser, Clarissa

“…Sulforaphane, an aliphatic isothiocyanate, is a known cancer chemopreventive agent. Aiming to investigate antiangiogenic potential of sulforaphane, we here…”
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Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-driven malignancies by Bartsch, Helmut, Nair, Jagadeesan

“…Chronic inflammatory processes produce an excess of ROS and DNA-reactive aldehydes from lipid peroxidation (LPO), such as trans-4-hydroxy-2-nonenal (HNE) and…”
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Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis by Bartsch, Helmut, Nair, Jagadeesan

“…During chronic inflammatory processes an excess of free radicals and DNA-reactive aldehydes from lipid peroxidation (LPO) are produced, which deregulate…”
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Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem, and root barks of Moringa oleifera Lam by Atawodi, Sunday E, Atawodi, Joy C, Idakwo, Gabriel A, Pfundstein, Beate, Haubner, Roswitha, Wurtele, Gerd, Bartsch, Helmut, Owen, Robert W

“…Medicinal plants have been shown to have both chemopreventive and/or therapeutic effects on cancer and other diseases related to oxidative damage. Moringa…”
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Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers by BARTSCH, H, NAIR, U, RISCH, A, ROJAS, M, WIKMAN, H, ALEXANDROV, K

“…Tobacco use is causally associated with cancers of the lung, larynx, mouth, esophagus, kidneys, urinary tract, and possibly, breast. Major classes of…”
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Olive-oil consumption and health: the possible role of antioxidants by Owen, R W, Giacosa, A, Hull, W E, Haubner, R, Würtele, G, Spiegelhalder, B, Bartsch, H

“…In the Mediterranean basin, olive oil, along with fruits, vegetables, and fish, is an important constituent of the diet, and is considered a major factor in…”
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Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis by Nair, Jagadeesan, Gansauge, Frank, Beger, Hans, Dolara, Piero, Winde, Günther, Bartsch, Helmut

“…Chronic inflammatory processes induce oxidative stress and lipid peroxidation (LPO), hereby generating DNA-reactive aldehydes such as trans-4-hydroxy-2-nonenal…”
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Polymorphisms in three base excision repair genes and breast cancer risk in Thai women by Sangrajrang, Suleeporn, Schmezer, Peter, Burkholder, Iris, Waas, Peter, Boffetta, Paolo, Brennan, Paul, Bartsch, Helmut, Wiangnon, Surapon, Popanda, Odilia

“…DNA repair plays an important role in tumor development. The base excision repair (BER) pathway mainly removes DNA damage caused by ionizing radiation and…”
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Lipid Peroxidation and Etheno DNA Adducts in White Blood Cells of Liver Fluke-Infected Patients: Protection by Plasma α-Tocopherol and Praziquantel by DECHAKHAMPHU, Somkid, PINLAOR, Somchai, SITTHITHAWORN, Paiboon, NAIR, Jagadeesan, BARTSCH, Helmut, YONGVANIT, Puangrat

“…Chronic infection by the liver fluke Opisthorchis viverrini is a strong risk factor for cholangiocarcinoma. To clarify the involvement of oxidative stress and…”
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Ultrasensitive and specific detection methods for exocylic DNA adducts: Markers for lipid peroxidation and oxidative stress by Bartsch, Helmut, Nair, Jagadeesan

“…Among exocyclic DNA adducts, etheno ( ε) bases ( εdA, εdC, N 2,3- εdG) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived…”
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Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early‐onset lung cancer by Timofeeva, Maria, Kropp, Silke, Sauter, Wiebke, Beckmann, Lars, Rosenberger, Albert, Illig, Thomas, Jäger, Birgit, Mittelstrass, Kirstin, Dienemann, Hendrik, Bartsch, Helmut, Bickeböller, Heike, Chang‐Claude, Jenny, Risch, Angela, Wichmann, Heinz‐Erich

“…Early‐onset lung cancer diagnosed up to the age of 50 is a very rare disease, with an increasing incidence rate. Differences in aetiology, characteristics and…”
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CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences by Timofeeva, Maria N., Kropp, Silke, Sauter, Wiebke, Beckmann, Lars, Rosenberger, Albert, Illig, Thomas, Jäger, Birgit, Mittelstrass, Kirstin, Dienemann, Hendrik, Bartsch, Helmut, Bickeböller, Heike, Chang-Claude, Jenny C., Risch, Angela, Wichmann, Heinz-Erich

“…Cytochrome P450 (CYP) enzymes, involved in metabolism of tobacco carcinogens, are also involved in estrogen metabolism and many are regulated by estrogens…”
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Identification of Lignans as Major Components in the Phenolic Fraction of Olive Oil by Owen, Robert W, Mier, Walter, Giacosa, Attilio, Hull, William E, Spiegelhalder, Bertold, Bartsch, Helmut

“…Because olive oil is an important component of the Mediterranean diet, it is necessary to establish unequivocal identification of the major potential…”
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High Excretion of Etheno Adducts in Liver Fluke–Infected Patients: Protection by Praziquantel against DNA Damage by DECHAKHAMPHU, Somkid, YONGVANIT, Puangrat, NAIR, Jagadeesan, PINLAOR, Somchai, SITTHITHAWORN, Paiboon, BARTSCH, Helmut

“…Chronic infection by Opisthorchis viverrini (OV) is a strong risk factor for developing cholangiocarcinoma (CCA). To clarify the involvement of oxidative…”
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The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease by Linhart, Kirsten-Berit, Glassen, Katharina, Peccerella, Teresa, Waldherr, Rüdiger, Linhart, Heinz, Bartsch, Helmut, Seitz, Helmut K.

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Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation by Nair, Jagadeesan, Strand, Susanne, Frank, Norbert, Knauft, Jutta, Wesch, Horst, Galle, Peter R., Bartsch, Helmut

“…Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced…”
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