Search Results - "Barton, Victoria"

The molecular mechanism of action of artemisinin--the debate continues by O'Neill, Paul M, Barton, Victoria E, Ward, Stephen A

“…Despite international efforts to 'roll back malaria' the 2008 World Malaria Report revealed the disease still affects approximately 3 billion people in 109…”
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Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 by Ismail, Hanafy M., Barton, Victoria, Phanchana, Matthew, Charoensutthivarakul, Sitthivut, Wong, Michael H. L., Hemingway, Janet, Biagini, Giancarlo A., O’Neill, Paul M., Ward, Stephen A.

“…The artemisinin (ART)-based antimalarials have contributed significantly to reducing global malaria deaths over the past decade, but we still do not know how…”
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A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile by Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.

“…In spite of the recent increase in endoperoxide antimalarials under development, it remains unclear if all these chemotypes share a common mechanism of action…”
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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

“…The iron‐y of fate: Isobole analyses of fluorescently labeled antimalarial endoperoxides with chelators selective for non‐heme iron, and laser confocal…”
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Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile by Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.

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Rationale Design of Biotinylated Antimalarial Endoperoxide Carbon Centered Radical Prodrugs for Applications in Proteomics by Barton, Victoria, Ward, Steven A, Chadwick, James, Hill, Alasdair, O’Neill, Paul M

“…The semisynthetic artemisinin derivatives such as artesunate and artemether, along with the fully synthetic endoperoxide antimalarials (e.g., OZ277, Nature…”
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Berichtigung: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile by Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.

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A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile by Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.

“…In spite of the recent increase in endoperoxide antimalarials under development, it remains unclear if all these chemotypes share a common mechanism of action…”
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Functional Characterization of W147A: A High-Affinity Interleukin-11 Antagonist by Underhill-Day, Nicholas, McGovern, Lisa A, Karpovich, Natalia, Mardon, Helen J, Barton, Victoria A, Heath, John K

“…IL-11 is a member of the gp130 family of cytokines, which signal via assembly of multisubunit receptor complexes containing at least one molecule of the…”
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A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum by Ward, Steve A, Fisher, Nicholas, Hill, Alasdair, Mbekeani, Alison, Shone, Alison, Nixon, Gemma, Stocks, Paul, Gibbons, Peter, Amewu, Richard, Hong, David W, Barton, Victoria, Pidathala, Chandra, Chadwick, James, Le Pensee, Louise, Warman, Ashley, Sharma, Raman, Berry, Neil G, O'Neill, Paul M, Biagini, Giancarlo A

“…References 1. 1. Biagini GA, Viriyavejakul P, O'neill PM, Bray PG, Ward SA: Functional characterization and target validation of alternative complex I of…”
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Inhibiting Plasmodium cytochrome bc1: a complex issue by Barton, Victoria, Fisher, Nicholas, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M

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Interleukin-11 Signals through the Formation of a Hexameric Receptor Complex by Barton, Victoria A., Hall, Mark A., Hudson, Keith R., Heath, John K.

“…Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which…”
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Longitudinal association of movement behaviour and motor competence in childhood: A structural equation model, compositional, and isotemporal substitution analysis by Estevan, Isaac, Clark, Cain, Molina-García, Javier, Menescardi, Cristina, Barton, Victoria, Queralt, Ana

“…ObjectivesThe aim of this study was to analyse the association between physical activity and motor competence in primary school children using traditional and…”
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Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A, Bray, Patrick G, Barton, Victoria E, Al-Helal, Mohammed, Jones, Michael, Araujo, Nuna C, Gibbons, Peter, Ward, Stephen A, Hughes, Ruth H, Biagini, Giancarlo A, Davies, Jill, Amewu, Richard, Mercer, Amy E, Ellis, Gemma, O'Neill, Paul M

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Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11 by Barton, V A, Hudson, K R, Heath, J K

“…Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which…”
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The effect of whole body vibration on sensorimotor deficits in people with chronic ankle instability: A systematic review and meta-analysis by Tan, Jingwang, Wu, Xueping, Clark, Cain C. T., Barton, Victoria, Chen, Sitong, Liu, Shijie, Zhou, Xuan, Xu, Chunxin, Ma, Tao, Qi, Bote, Han, Jia, Zou, Yu

“…Objective To investigate the effects of whole body vibration on chronic ankle instability-associated sensorimotor deficits in balance, strength, joint position…”
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Inhibiting Plasmodium cytochrome bc1: a complex issue by Barton, Victoria, Fisher, Nicholas, Biagini, Giancarlo A, Ward, Stephen A, O'Neill, Paul M

“…The cytochrome bc(1) complex is a key mitochondrial enzyme that catalyses transfer of electrons maintaining the membrane potential of mitochondria. Currently,…”
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Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins by O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A

“…Fighting drug resistence: From a library of over 150 1,2,4,5‐tetraoxanes, the candidate RKA 182 was selected for preclinical development as an antimalarial…”
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Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines : synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates by ARAUJO, Nuna C. P, BARTON, Victoria, JONES, Michael, STOCKS, Paul A, WARD, Stephen A, DAVIES, Jill, BRAY, Patrick G, SHONE, Alison E, CRISTIANO, Maria L. S, O'NEILL, Paul M

“…A novel series of semi-synthetic trioxaquines and synthetic trioxolaquines were prepared, in moderate to good yields. Antimalarial activity was evaluated…”
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Analytical review of the current state of knowledge of adsorption materials and processes for direct air capture by Low, May-Yin (Ashlyn), Barton, Lucy Victoria, Pini, Ronny, Petit, Camille

“…Significant research interest has been directed towards the deployment of direct air capture (DAC) as a net-negative CO2 emissions technology to help limit…”
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