Search Results - "Barton, Naomi"

Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling by Ahmed, Ahmed Abdullah, Chen, Shuang, Roman-Escorza, Maria, Angell, Richard, Oxenford, Sally, McConville, Matthew, Barton, Naomi, Sunose, Mihiro, Neidle, Dan, Haider, Shozeb, Arshad, Tariq, Neidle, Stephen

“…The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4) DNA structures. It shows high potency in pancreatic ductal adenocarcinoma…”
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Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)­sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)­(4-(trifluoromethyl)­pyridin-2-yl)­methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist by Hunt, Hazel J, Belanoff, Joseph K, Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily

“…The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing’s…”
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Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models by Ahmed, Ahmed A, Angell, Richard, Oxenford, Sally, Worthington, Jenny, Williams, Nicole, Barton, Naomi, Fowler, Thomas G, O’Flynn, Daniel E, Sunose, Mihiro, McConville, Matthew, Vo, Tam, Wilson, W. David, Karim, Saadia A, Morton, Jennifer P, Neidle, Stephen

“…Targeting of genomic quadruplexes is an approach to treating complex human cancers. We describe a series of tetra-substituted naphthalene diimide (ND)…”
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Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway? by Barton, Naomi A, Marsh, Benjamin J, Lewis, William, Narraidoo, Nathalie, Seymour, Graham B, Fray, Rupert, Hayes, Christopher J

“…We have shown for the first time that taxadiene ( 3 ) can be epoxidised in a regio- and diastereoselective manner to provide taxadiene-4(5)-epoxide ( 12 ) as a…”
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Identification of the Clinical Candidate ( R )-(1-(4-Fluorophenyl)-6-((1-methyl-1 H -pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1 H -pyrazolo[3,4- g ]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist by Hunt, Hazel J., Belanoff, Joseph K., Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily

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Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?† †Electronic supplementary information (ESI) available: Full experimental procedures and copies of 1H and 13C NMR spectra. CCDC 1030909. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03463a by Barton, Naomi A., Marsh, Benjamin J., Lewis, William, Narraidoo, Nathalie, Seymour, Graham B., Fray, Rupert, Hayes, Christopher J.

“…We report the first synthesis of taxadiene-4(5)-epoxide, which rearranges upon acid treatment to produce products of relevance to taxol biosynthesis. We have…”
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