Search Results - "Bartom, Elizabeth T."

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
Get full text

SPOROS: A pipeline to analyze DISE/6mer seed toxicity by Bartom, Elizabeth T, Kocherginsky, Masha, Paudel, Bidur, Vaidyanathan, Aparajitha, Haluck-Kangas, Ashley, Patel, Monal, O'Shea, Kaitlyn L, Murmann, Andrea E, Peter, Marcus E

“…microRNAs (miRNAs) are (18-22nt long) noncoding short (s)RNAs that suppress gene expression by targeting the 3' untranslated region of target mRNAs. This…”
Get full text

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
Get full text

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
Get full text

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2 by Mandal, Malay, Powers, Sarah E, Maienschein-Cline, Mark, Bartom, Elizabeth T, Hamel, Keith M, Kee, Barbara L, Dinner, Aaron R, Clark, Marcus R

“…The transcription factor STAT5 commonly activates gene transcription. Clark and colleagues show that tetrameric STAT5, induced by high concentrations of…”
Get full text

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite…”
Get full text

ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis by DiGiuseppe, Stephen, Rollins, Madeline G., Bartom, Elizabeth T., Walsh, Derek

“…Post-translational modification of ribosomal subunit proteins (RPs) is emerging as an important means of regulating gene expression. Recently, regulatory…”
Get full text

The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma by Ladomersky, Erik, Scholtens, Denise M, Kocherginsky, Masha, Hibler, Elizabeth A, Bartom, Elizabeth T, Otto-Meyer, Sebastian, Zhai, Lijie, Lauing, Kristen L, Choi, Jaehyuk, Sosman, Jeffrey A, Wu, Jennifer D, Zhang, Bin, Lukas, Rimas V, Wainwright, Derek A

“…Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is associated with a median overall survival (mOS) of 16-21 months. Our previous…”
Get full text

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity by Luo, Zhuojuan, Lin, Chengqi, Woodfin, Ashley R, Bartom, Elizabeth T, Gao, Xin, Smith, Edwin R, Shilatifard, Ali

“…Genomic imprinting is a critical developmental process characteristic of parent of origin-specific gene expression. It is well accepted that differentially…”
Get full text

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia by McNerney, Megan E., Brown, Christopher D., Wang, Xiaoyue, Bartom, Elizabeth T., Karmakar, Subhradip, Bandlamudi, Chaitanya, Yu, Shan, Ko, Jinkyung, Sandall, Barry P., Stricker, Thomas, Anastasi, John, Grossman, Robert L., Cunningham, John M., Le Beau, Michelle M., White, Kevin P.

“…Loss of chromosome 7 and del(7q) [−7/del(7q)] are recurring cytogenetic abnormalities in hematologic malignancies, including acute myeloid leukemia and…”
Get full text

Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations by Zhao, Zibo, Cao, Kaixiang, Watanabe, Jun, Philips, Cassandra N, Zeidner, Jacob M, Ishi, Yukitomo, Wang, Qixuan, Gold, Sarah R, Junkins, Katherine, Bartom, Elizabeth T, Yue, Feng, Chandel, Navdeep S, Hashizume, Rintaro, Ben-Sahra, Issam, Shilatifard, Ali

“…Epigenetic status-altering mutations in chromatin-modifying enzymes are a feature of human diseases, including many cancers. However, the functional outcomes…”
Get full text

SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression by Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Morgan, Marc A, Rendleman, Emily J, Wang, Lu, Sze, Christie C, Sun, Tianjiao, Bartom, Elizabeth T, Shilatifard, Ali

“…The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression…”
Get full text

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication by Wang, Yi-Zhi, Castillon, Charlotte C.M., Gebis, Kamil K., Bartom, Elizabeth T., d’Azzo, Alessandra, Contractor, Anis, Savas, Jeffrey N.

“…Extracellular vesicles (EVs) facilitate intercellular communication by transferring cargo between cells in a variety of tissues. However, how EVs achieve…”
Get full text

Kaposi’s Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma by Manzano, Mark, Günther, Thomas, Ju, Hyunwoo, Nicholas, John, Bartom, Elizabeth T., Grundhoff, Adam, Gottwein, Eva

“…Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the aggressive disease primary effusion lymphoma (PEL). Here, we show that a viral transcription factor…”
Get full text

Identification of the toxic 6mer seed consensus for human cancer cells by Patel, Monal, Bartom, Elizabeth T., Paudel, Bidur, Kocherginsky, Masha, O’Shea, Kaitlyn L., Murmann, Andrea E., Peter, Marcus E.

“…6mer seed toxicity is a novel cell death mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si-…”
Get full text

6mer seed toxicity in tumor suppressive microRNAs by Gao, Quan Q., Putzbach, William E., Murmann, Andrea E., Chen, Siquan, Sarshad, Aishe A., Peter, Johannes M., Bartom, Elizabeth T., Hafner, Markus, Peter, Marcus E.

“…Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen…”
Get full text

Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging by Paudel, Bidur, Jeong, Si-Yeon, Martinez, Carolina Pena, Rickman, Alexis, Haluck-Kangas, Ashley, Bartom, Elizabeth T., Fredriksen, Kristina, Affaneh, Amira, Kessler, John A., Mazzulli, Joseph R., Murmann, Andrea E., Rogalski, Emily, Geula, Changiz, Ferreira, Adriana, Heckmann, Bradlee L., Green, Douglas R., Sadleir, Katherine R., Vassar, Robert, Peter, Marcus E.

“…Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death…”
Get full text

The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family by Morrison, Kylee, Manzano, Mark, Chung, Kevin, Schipma, Matthew J., Bartom, Elizabeth T., Gottwein, Eva

“…Many tumor viruses encode oncogenes of cellular origin. Here, we report an oncoviral mimic of a cellular tumor suppressor. The Kaposi’s sarcoma-associated…”
Get full text

Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue by Hajirahimkhan, Atieh, Howell, Caitlin, Bartom, Elizabeth T., Dong, Huali, Lantvit, Daniel D., Xuei, Xiaoling, Chen, Shao-Nong, Pauli, Guido F., Bolton, Judy L., Clare, Susan E., Khan, Seema A., Dietz, Birgit M.

“…Breast cancer risk continues to increase post menopause. Anti-estrogen therapies are available to prevent postmenopausal breast cancer in high-risk women…”
Get full text

The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference by Murmann, Andrea E., Patel, Monal, Jeong, Si-Yeon, Bartom, Elizabeth T., Jennifer Morton, A., Peter, Marcus E.

“…Extended CAG trinucleotide repeats (TNR) in the genes huntingtin ( HTT ) and androgen receptor ( AR ) are the cause of two progressive neurodegenerative…”
Get full text