Search Results - "Bartol, Thomas M"

Nanoconnectomic upper bound on the variability of synaptic plasticity by Bartol, Thomas M, Bromer, Cailey, Kinney, Justin, Chirillo, Michael A, Bourne, Jennifer N, Harris, Kristen M, Sejnowski, Terrence J

“…Information in a computer is quantified by the number of bits that can be stored and recovered. An important question about the brain is how much information…”
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NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95 by Compans, Benjamin, Camus, Come, Kallergi, Emmanouela, Sposini, Silvia, Martineau, Magalie, Butler, Corey, Kechkar, Adel, Klaassen, Remco V., Retailleau, Natacha, Sejnowski, Terrence J., Smit, August B., Sibarita, Jean-Baptiste, Bartol, Thomas M., Perrais, David, Nikoletopoulou, Vassiliki, Choquet, Daniel, Hosy, Eric

“…Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD…”
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Anomalous Diffusion of Single Particles in Cytoplasm by Regner, Benjamin M., Vučinić, Dejan, Domnisoru, Cristina, Bartol, Thomas M., Hetzer, Martin W., Tartakovsky, Daniel M., Sejnowski, Terrence J.

“…The crowded intracellular environment poses a formidable challenge to experimental and theoretical analyses of intracellular transport mechanisms. Our…”
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Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency by Haas, Kalina T, Compans, Benjamin, Letellier, Mathieu, Bartol, Thomas M, Grillo-Bosch, Dolors, Sejnowski, Terrence J, Sainlos, Matthieu, Choquet, Daniel, Thoumine, Olivier, Hosy, Eric

“…The nanoscale organization of neurotransmitter receptors regarding pre-synaptic release sites is a fundamental determinant of the synaptic transmission…”
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Mitochondrial morphology provides a mechanism for energy buffering at synapses by Garcia, Guadalupe C., Bartol, Thomas M., Phan, Sébastien, Bushong, Eric A., Perkins, Guy, Sejnowski, Terrence J., Ellisman, Mark H., Skupin, Alexander

“…Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to…”
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Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil by Kinney, Justin P., Spacek, Josef, Bartol, Thomas M., Bajaj, Chandrajit L., Harris, Kristen M., Sejnowski, Terrence J.

“…Although the extracellular space in the neuropil of the brain is an important channel for volume communication between cells and has other important functions,…”
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Long-term potentiation expands information content of hippocampal dentate gyrus synapses by Bromer, Cailey, Bartol, Thomas M., Bowden, Jared B., Hubbard, Dusten D., Hanka, Dakota C., Gonzalez, Paola V., Kuwajima, Masaaki, Mendenhall, John M., Parker, Patrick H., Abraham, Wickliffe C., Sejnowski, Terrence J., Harris, Kristen M.

“…An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic…”
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Computer simulations predict the impact of neuronal atrophy on the calcium dynamics in Huntington's disease by Sameni, Sara, Bartol, Jr, Thomas M, Corey-Bloom, Jody, Sejnowski, Terrence J

“…One of the early hallmarks of Huntington's disease (HD) is neuronal cell atrophy, especially in the striatum, underlying motor dysfunction in HD. Here using a…”
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Multiscale modeling of presynaptic dynamics from molecular to mesoscale by Garcia, Jonathan W, Bartol, Thomas M, Sejnowski, Terrence J

“…Chemical synapses exhibit a diverse array of internal mechanisms that affect the dynamics of transmission efficacy. Many of these processes, such as release of…”
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MCell4 with BioNetGen: A Monte Carlo simulator of rule-based reaction-diffusion systems with Python interface by Husar, Adam, Ordyan, Mariam, Garcia, Guadalupe C, Yancey, Joel G, Saglam, Ali S, Faeder, James R, Bartol, Thomas M, Kennedy, Mary B, Sejnowski, Terrence J

“…Biochemical signaling pathways in living cells are often highly organized into spatially segregated volumes, membranes, scaffolds, subcellular compartments,…”
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Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing by Wagner, Margot, Bartol, Thomas M, Sejnowski, Terrence J, Cauwenberghs, Gert

“…Progress in computational neuroscience toward understanding brain function is challenged both by the complexity of molecular-scale electrochemical interactions…”
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Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines by Keller, Daniel X, Franks, Kevin M, Bartol, Jr, Thomas M, Sejnowski, Terrence J

“…The entry of calcium into dendritic spines can trigger a sequence of biochemical reactions that begins with the activation of calmodulin (CaM) and ends with…”
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Correction: Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency by Haas, Kalina T, Compans, Benjamin, Letellier, Mathieu, Bartol, Jr, Thomas M, Grillo-Bosch, Dolors, Sejnowski, Terrence J, Sainlos, Matthieu, Choquet, Daniel, Thoumine, Olivier, Hosy, Eric

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A multi-state model of the CaMKII dodecamer suggests a role for calmodulin in maintenance of autophosphorylation by Pharris, Matthew C, Patel, Neal M, VanDyk, Tyler G, Bartol, Thomas M, Sejnowski, Terrence J, Kennedy, Mary B, Stefan, Melanie I, Kinzer-Ursem, Tamara L

“…Ca2+/calmodulin-dependent protein kinase II (CaMKII) accounts for up to 2 percent of all brain protein and is essential to memory function. CaMKII activity is…”
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Multi-state modeling of biomolecules by Stefan, Melanie I, Bartol, Thomas M, Sejnowski, Terrence J, Kennedy, Mary B

“…Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behavior of biological molecules or complexes that can…”
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Efficient Multiscale Models of Polymer Assembly by Ruiz-Martinez, Alvaro, Bartol, Thomas M., Sejnowski, Terrence J., Tartakovsky, Daniel M.

“…Protein polymerization and bundling play a central role in cell physiology. Predictive modeling of these processes remains an open challenge, especially when…”
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Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal by Nadkarni, Suhita, Bartol, Thomas M, Stevens, Charles F, Sejnowski, Terrence J, Levine, Herbert

“…Although the CA3–CA1 synapse is critically important for learning and memory, experimental limitations have to date prevented direct determination of the…”
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Modelling vesicular release at hippocampal synapses by Nadkarni, Suhita, Bartol, Thomas M, Sejnowski, Terrence J, Levine, Herbert

“…We study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially explicit, biophysical model of the CA3-CA1 presynaptic bouton. The…”
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Imbalance of ionic conductances contributes to diverse symptoms of demyelination by Coggan, Jay S., Prescott, Steven A., Bartol, Thomas M., Sejnowski, Terrence J.

“…Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically…”
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Computational reconstitution of spine calcium transients from individual proteins by Bartol, Thomas M, Keller, Daniel X, Kinney, Justin P, Bajaj, Chandrajit L, Harris, Kristen M, Sejnowski, Terrence J, Kennedy, Mary B

“…We have built a stochastic model in the program MCell that simulates Ca(2+) transients in spines from the principal molecular components believed to control…”
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