Search Results - "Bartholomew, Sadie"

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle by Kawas, Raja F., Anderson, Robert L., Ingle, Sadie R. Bartholomew, Song, Yonghong, Sran, Arvinder S., Rodriguez, Hector M.

“…Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying sarcomere…”
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A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division by Manor, Uri, Bartholomew, Sadie, Golani, Gonen, Christenson, Eric, Kozlov, Michael, Higgs, Henry, Spudich, James, Lippincott-Schwartz, Jennifer

“…Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting…”
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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin by Spudich, James A, Aksel, Tural, Bartholomew, Sadie R, Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S, Sung, Jongmin, Sommese, Ruth F, Sutton, Shirley, Cho, Carol, Adhikari, Arjun S, Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M

“…Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide…”
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The Research Software Encyclopedia: A Community Framework to Define Research Software by Sochat, Vanessa, May, Nicholas, Cosden, Ian, Martinez-Ortiz, Carlos, Bartholomew, Sadie

“…The Research Software Encyclopedia is a community driven, open source strategy to define the term "research software" in different contexts. It consists of…”
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What Do We (Not) Know About Research Software Engineering? by Lamprecht, Anna-Lena, Martinez-Ortiz, Carlos, Barker, Michelle, Bartholomew, Sadie L., Barton, Justin, Hong, Neil Chue, Cohen, Jeremy, Druskat, Stephan, Forest, Jeremy, Grad, Jean-Noël, Katz, Daniel S., Richardson, Robin, Rosca, Robert, Schulte, Douwe, Struck, Alexander, Weinzierl, Marion

“…As recognition of the vital importance of software for contemporary research is increasing, Research Software Engineering (RSE) is emerging as a discipline in…”
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Distinct cellular pools of perilipin 5 point to roles in lipid trafficking by Bartholomew, Sadie R., Bell, Erica Hlavin, Summerfield, Taryn, Newman, Leslie C., Miller, Erin L., Patterson, Brian, Niday, Zach P., Ackerman, William E., Tansey, John T.

“…The PAT family of lipid storage droplet proteins comprised five members, each of which has become an established regulator of cellular neutral lipid…”
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Cost-effective engineering of a small-scale bioreactor by Bartholomew, Sadie R., Tansey, John T.

“…Several methods exist for increasing the scale of cell culture in the laboratory. While these methods provide significant increases in biomass, they are often…”
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cfdm: A Python reference implementation of the CF data model by Hassell, David, Bartholomew, Sadie

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Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease by Wang, Jun, Ho, Lap, Chen, Linghong, Zhao, Zhong, Zhao, Wei, Qian, Xianjuan, Humala, Nelson, Seror, Ilana, Bartholomew, Sadie, Rosendorff, Clive, Pasinetti, Giulio Maria

“…Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically…”
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Workflow Automation for Cycling Systems by Oliver, Hilary, Shin, Matthew, Matthews, David, Sanders, Oliver, Bartholomew, Sadie, Clark, Andrew, Fitzpatrick, Ben, van Haren, Ronald, Hut, Rolf, Drost, Niels

“…Complex cycling workflows are fundamental to numerical weather prediction (NWP) and related environmental forecasting systems. Large numbers of jobs are…”
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2-Deoxy-ATP Enhances Multiple Kinetic Parameters to Improve Cardiac Function by Tomasic, Ivan B., Henze, Marcus, Evangelista, Ferdinand, Anto, Anu R., Rodriguez, Hector, Bartholomew, Sadie R.

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Distinct pools of OXPAT suggest roles in lipid trafficking by Tansey, John T, Bartholomew, Sadie R, Hlavin, Erica M, Summerfield, Taryn L, Ackerman, William E

“…Abstract only…”
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Expression of PAT‐1/MLDP increases triacylglycerol stores and promotes changes in lipid droplet morphology in a CHO cell model by Bartholomew, Sadie R, Hlavin, Erica M, Summerfield, Taryn L, Ackerman, William E, Tansey, John T

“…All cells have specific organelles for the sequestration of neutral lipid stores termed lipid storage droplets (LDs). These organelles have a proteinaceous…”
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Valsartan lowers brain [beta]-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease by Wang, Jun, Ho, Lap, Chen, Linghong, Zhao, Zhong, Zhao, Wei, Qian, Xianjuan, Humala, Nelson, Seror, Ilana, Bartholomew, Sadie, Rosendorff, Clive, Pasinetti, Giulio Maria

“…Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically…”
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Abstract 16: A Minipig Genetic Model of Hypertrophic Cardiomyopathy by Green, Eric M, Weiss, Robert M, Divekar, Abhay, Bartholomew Ingle, Sadie R, Henze, Marcus, Kawas, Raja, Gifford, Lindsey, Davis, Melissa K, Rohret, Frank, Thedens, Daniel R, Rodriguez, Hector M, Evanchik, Marc J, Anderson, Robert L, Sieren, Jessica, Rogers, Christopher S, Meyerholz, David K, Ahmad, Ferhaan

“…Abstract only Introduction: Hypertrophic cardiomyopathy (HCM) is a heritable disease of heart muscle associated with increased risk of heart failure and sudden…”
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Myosin Regulatory Proteins Mediate Hypertrophic Cardiomyopathy and Mitochondrial Homeostasis by Ingle, Sadie Rae Bartholomew

“…The eukaryotic actin and microtubule cytoskeleton is extremely dynamic and complex. Actin and microtubule filaments, together with their accessory proteins,…”
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Abstract 14467: A Minipig Genetic Model of Hypertrophic Cardiomyopathy by Green, Eric M, Weiss, Robert M, Divekar, Abhay, Bartholomew Ingle, Sadie R, Henze, Marcus, Evanchik, Marc J, Kawas, Raja, Gifford, Lindsey M, Davis, Melissa K, Rohret, Frank A, Thedens, Daniel R, Rodriguez, Hector M, Anderson, Robert L, Sieren, Jessica, Rogers, Christopher S, Meyerholz, David K, Ahmad, Ferhaan

“…IntroductionHCM is a heritable disease of heart muscle associated with increased risk of heart failure and sudden death. Mutations in genes encoding sarcomere…”
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