Search Results - "Bartholomeeusen, Koen"

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein by Bartholomeeusen, Koen, Xiang, Yanhui, Fujinaga, Koh, Peterlin, B.Matija

“…By phosphorylating elongation factors and the C-terminal domain of RNA polymerase II, the positive transcription elongation factor b (P-TEFb) is the critical…”
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The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes by Blazek, Dalibor, Kohoutek, Jiri, Bartholomeeusen, Koen, Johansen, Eric, Hulinkova, Petra, Luo, Zeping, Cimermancic, Peter, Ule, Jernej, Peterlin, B Matija

“…Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of transcription. In this study, we identified a 70-kDa Cyclin K (CycK)…”
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Structural and Functional Analysis of the Cdk13/Cyclin K Complex by Greifenberg, Ann Katrin, Hönig, Dana, Pilarova, Kveta, Düster, Robert, Bartholomeeusen, Koen, Bösken, Christian A., Anand, Kanchan, Blazek, Dalibor, Geyer, Matthias

“…Cyclin-dependent kinases regulate the cell cycle and transcription in higher eukaryotes. We have determined the crystal structure of the transcription kinase…”
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Cross-utilisation of template RNAs by alphavirus replicases by Lello, Laura Sandra, Utt, Age, Bartholomeeusen, Koen, Wang, Sainan, Rausalu, Kai, Kendall, Catherine, Coppens, Sandra, Fragkoudis, Rennos, Tuplin, Andrew, Alphey, Luke, Ariën, Kevin K, Merits, Andres

“…Most alphaviruses (family Togaviridae) including Sindbis virus (SINV) and other human pathogens, are transmitted by arthropods. The first open reading frame in…”
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Mayaro virus, a potential threat for Europe: vector competence of autochthonous vector species by Brustolin, Marco, Bartholomeeusen, Koen, Rezende, Tatiana, Ariën, Kevin K, Müller, Ruth

“…Mayaro virus (MAYV) is an emerging alphavirus, primarily transmitted by the mosquito Haemagogus janthinomys in Central and South America. However, recent…”
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Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant by Ariën, Kevin K., Heyndrickx, Leo, Michiels, Johan, Vereecken, Katleen, Van Lent, Kurt, Coppens, Sandra, Willems, Betty, Pannus, Pieter, Martens, Geert A., Van Esbroeck, Marjan, Goossens, Maria E., Marchant, Arnaud, Bartholomeeusen, Koen, Desombere, Isabelle

“…We report the levels of neutralising antibodies against Wuhan, Delta and Omicron variants in unimmunized infected (group 1), immunised and boosted (group 2)…”
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Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2 by Mariën, Joachim, Michiels, Johan, Heyndrickx, Leo, Nkuba-Ndaye, Antoine, Ceulemans, Ann, Bartholomeeusen, Koen, Madinga, Joule, Mbala-Kingebeni, Placide, Vanlerberghe, Veerle, Ahuka-Mundeke, Steve, Wang, Lin-Fa, Ariën, Kevin K.

“…•GenScript cPass is a user-friendly commercial neutralising antibodies(nAb) assay.•The assay sensitivity was high when tested in DRC (88 %) and Belgium (94…”
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The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells by De Caluwé, Lien, Coppens, Sandra, Vereecken, Katleen, Daled, Simon, Dhaenens, Maarten, Van Ostade, Xaveer, Deforce, Dieter, Ariën, Kevin K, Bartholomeeusen, Koen

“…Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the…”
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Broad-spectrum monoclonal antibodies against chikungunya virus structural proteins: Promising candidates for antibody-based rapid diagnostic test development by Tuekprakhon, Aekkachai, Puiprom, Orapim, Sasaki, Tadahiro, Michiels, Johan, Bartholomeeusen, Koen, Nakayama, Emi E, Meno, Michael K, Phadungsombat, Juthamas, Huits, Ralph, Ariën, Kevin K, Luplertlop, Natthanej, Shioda, Tatsuo, Leaungwutiwong, Pornsawan

“…In response to the aggressive global spread of the mosquito-borne chikungunya virus (CHIKV), an accurate and accessible diagnostic tool is of high importance…”
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Dynamics of the Magnitude, Breadth and Depth of the Antibody Response at Epitope Level Following Dengue Infection by Falconi-Agapito, Francesca, Kerkhof, Karen, Merino, Xiomara, Michiels, Johan, Van Esbroeck, Marjan, Bartholomeeusen, Koen, Talledo, Michael, Ariën, Kevin K.

“…Dengue is a major public health problem in tropical and sub-tropical regions worldwide. Since the Zika epidemic and the increased co-circulation of other…”
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Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells by De Caluwé, Lien, Heyndrickx, Leo, Coppens, Sandra, Vereecken, Katleen, Quiñones-Mateu, Miguel E, Merits, Andres, Ariën, Kevin K, Bartholomeeusen, Koen

“…Chikungunya virus (CHIKV) is an emerging arthropod-borne virus that has spread globally during the last two decades. The virus is mainly transmitted by and…”
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Variation at position 350 in the Chikungunya virus 6K-E1 protein determines the sensitivity of detection in a rapid E1-antigen test by Tuekprakhon, Aekkachai, Nakayama, Emi E., Bartholomeeusen, Koen, Puiprom, Orapim, Sasaki, Tadahiro, Huits, Ralph, Luplertlop, Natthanej, Kosoltanapiwat, Nathamon, Maneekan, Pannamas, Ariën, Kevin K., Shioda, Tatsuo, Leaungwutiwong, Pornsawan

“…Chikungunya virus (CHIKV), a mosquito-borne pathogen, consists of three genotypes: East/Central/South African (ECSA), West African (WA), and Asian. Although a…”
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Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors by Binning, Jennifer M, Smith, Amber M, Hultquist, Judd F, Craik, Charles S, Caretta Cartozo, Nathalie, Campbell, Melody G, Burton, Lily, La Greca, Florencia, McGregor, Michael J, Ta, Hai M, Bartholomeeusen, Koen, Peterlin, B Matija, Krogan, Nevan J, Sevillano, Natalia, Cheng, Yifan, Gross, John D

“…The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV…”
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Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ by Bartholomeeusen, Koen, Christ, Frauke, Hendrix, Jelle, Rain, Jean-Christophe, Emiliani, Stéphane, Benarous, Richard, Debyser, Zeger, Gijsbers, Rik, De Rijck, Jan

“…Lens epithelium-derived growth factor/p75 (LEDGF/p75) is a prominent cellular interaction partner of human immunodeficiency virus-1 (HIV-1) integrase,…”
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Genome Mining Uncovers NRPS and PKS Clusters in Rothia dentocariosa with Inhibitory Activity against Neisseria Species by Akomoneh, Elvis Achondou, Gestels, Zina, Abdellati, Saïd, Vereecken, Katleen, Bartholomeeusen, Koen, Van den Bossche, Dorien, Kenyon, Chris, Manoharan-Basil, Sheeba Santhini

“…The growing global threat of antimicrobial resistance is reaching a crisis point as common bacterial infections, including those caused by pathogenic Neisseria…”
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Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G by Stanley, David J, Bartholomeeusen, Koen, Crosby, David C, Kim, Dong Young, Kwon, Eunju, Yen, Linda, Cartozo, Nathalie Caretta, Li, Ming, Jäger, Stefanie, Mason-Herr, Jeremy, Hayashi, Fumiaki, Yokoyama, Shigeyuki, Krogan, Nevan J, Harris, Reuben S, Peterlin, Boris Matija, Gross, John D

“…Cellular restriction factors help to defend humans against human immunodeficiency virus (HIV). HIV accessory proteins hijack at least three different…”
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Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia by Huits, Ralph, De Kort, Jaclyn, Van Den Berg, Riemsdijk, Chong, Luis, Tsoumanis, Achilleas, Eggermont, Kaat, Bartholomeeusen, Koen, Ariën, Kevin K, Jacobs, Jan, Van Esbroeck, Marjan, Bottieau, Emmanuel, Cnops, Lieselotte

“…Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of…”
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Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection of a Healthcare Worker in a Belgian Nosocomial Outbreak Despite Primary Neutralizing Antibody Response by Selhorst, Philippe, van Ierssel, Sabrina H, Michiels, Jo, Mariën, Joachim, Bartholomeeusen, Koen, Dirinck, Eveline, Vandamme, Sarah, Jansens, Hilde, Ariën, Kevin K

“…Abstract Background It is currently unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection will remain a rare event, only…”
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nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity by Lello, Laura Sandra, Bartholomeeusen, Koen, Wang, Sainan, Coppens, Sandra, Fragkoudis, Rennos, Alphey, Luke, Ariën, Kevin K, Merits, Andres, Utt, Age

“…Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the nonstructural (ns) polyproteins P123 and…”
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CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes by Chirackal Manavalan, Anil Paul, Pilarova, Kveta, Kluge, Michael, Bartholomeeusen, Koen, Rajecky, Michal, Oppelt, Jan, Khirsariya, Prashant, Paruch, Kamil, Krejci, Lumir, Friedel, Caroline C, Blazek, Dalibor

“…CDK12 is a kinase associated with elongating RNA polymerase II (RNAPII) and is frequently mutated in cancer. CDK12 depletion reduces the expression of…”
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