Search Results - "Barthlott, T"

CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production by Barthlott, Thomas, Moncrieffe, Halima, Veldhoen, Marc, Atkins, Christopher J., Christensen, Jillian, O'Garra, Anne, Stockinger, Brigitta

“…Maintenance of homeostasis in the immune system involves competition for resources between T lymphocytes, which avoids the development of immune pathology seen…”
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Differential Survival of Naive CD4 and CD8 T Cells by Ferreira, Cristina, Barthlott, Thomas, Garcia, Sylvie, Zamoyska, Rose, Stockinger, Brigitta

“…In this paper we compare survival characteristics of transgenic and polyclonal CD4 and CD8 T cells. Transgenic CD4 T cells have an intrinsically lower capacity…”
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A short primer on early molecular and cellular events in thymus organogenesis and replacement by Barthlott, T, Keller, MP, Hollnder, GA

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T cell regulation as a side effect of homeostasis and competition by Barthlott, Thomas, Kassiotis, George, Stockinger, Brigitta

“…We have previously hypothesized that maintaining a balanced peripheral immune system may not be the sole responsibility of a specialized subset of T cells…”
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IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells by Vieira, Pedro L, Christensen, Jillian R, Minaee, Sophie, O'Neill, Emma J, Barrat, Franck J, Boonstra, Andre, Barthlott, Thomas, Stockinger, Brigitta, Wraith, David C, O'Garra, Anne

“…Regulatory T cells (T(Reg)) control immune responses to self and nonself Ags. The relationship between Ag-driven IL-10-secreting T(Reg) (IL-10-T(Reg)) and…”
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The concept of space and competition in immune regulation by Stockinger, Brigitta, Barthlott, Thomas, Kassiotis, George

“…Regulation of cell numbers and organ size in multicellular organisms is an important principle in biology. Experimental data in developmental biology indicate…”
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T cell regulation: a special job or everyone's responsibility? by Stockinger, Brigitta, Barthlott, Thomas, Kassiotis, George

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EVA regulates thymic stromal organisation and early thymocyte development by DeMonte, Lucia, Porcellini, Simona, Tafi, Elisiana, Sheridan, Julie, Gordon, Julie, Depreter, Marianne, Blair, Natalie, Panigada, Maddalena, Sanvito, Francesca, Merati, Barbara, Albientz, Anita, Barthlott, Thomas, Ozmen, Laurence, Blackburn, C. Clare, Guttinger, Maria

“…Epithelial V-like antigen (EVA) is an immunoglobulin-like adhesion molecule identified in a screen for molecules developmentally regulated at the DN to DP…”
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Activation of CD8 T Cells by Antigen Expressed in the Pituitary Gland by de Jersey, James, Carmignac, Danielle, Barthlott, Thomas, Robinson, Iain, Stockinger, Brigitta

“…Ag expressed exclusively in the anterior pituitary gland and secreted locally by pituitary somatotrophs can gain access to the MHC class I presentation pathway…”
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Factors affecting the susceptibility of the mouse pituitary gland to CD8 T‐cell‐mediated autoimmunity by De Jersey, James, Carmignac, Danielle, Le Tissier, Paul, Barthlott, Thomas, Robinson, Iain, Stockinger, Brigitta

“…Summary We have previously shown, in a transgenic mouse model, that the pituitary gland is susceptible to CD8 T‐cell‐mediated autoimmunity, triggered by a…”
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Lineage fate alteration of thymocytes developing in an MHC environment containing MHC / peptide ligands with antagonist properties by Barthlott, Thomas, Stockinger, Brigitta

“…A18 TCR transgenic thymocytes which are H‐2Ek restricted and normally selected into the CD4 lineage, are exclusively selected into the CD8 lineage in an H‐2q…”
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Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage by Volkmann, A, Barthlott, T, Weiss, S, Frank, R, Stockinger, B

“…CD4/CD8 lineage decision is an important event during T cell maturation in the thymus. CD8 T cell differentiation usually requires corecognition of major…”
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Differentiation of CD4(high)CD8(low) coreceptor-skewed thymocytes into mature CD8 single-positive cells independent of MHC class I recognition by Barthlott, T, Kohler, H, Pircher, H, Eichmann, K

“…Thymocytes with a CD4(hi)CD8(lo) coreceptor-skewed (CRS) phenotype have been shown to contain precursors for CD8 single-positive (SP) thymocytes, in addition…”
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Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor by Barthlott, T, Kohler, H, Eichmann, K

“…In several experimental systems analyzing the generation of single positive (SP) thymocytes from double positive (DP) thymocytes, CD4 SP cells have been shown…”
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Normal Thymic Selection of TCR Transgenic CD4 T Cells, but Impaired Survival in the Periphery Despite the Presence of Selecting MHC Molecules by Barthlott, Thomas, Wright, Rebecca J, Stockinger, Brigitta

“…In this paper, we investigate selection in the thymus and survival in the periphery of CD4 T cells, which carry a major histocompatibility class II-restricted…”
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Immature T cells in peripheral lymphoid organs of recombinase- activating gene-1/-2-deficient mice. Thymus dependence and responsiveness to anti-CD3 epsilon antibody by Falk, I, Potocnik, AJ, Barthlott, T, Levelt, CN, Eichmann, K

“…Thymocytes of mice deficient in the recombinase-activating gene (RAG)-1 or RAG-2 cannot express and receive signals through the pre-TCR. As a result, thymocyte…”
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A novel mouse thymocyte antigen (F3Ag): Down-regulation during the CD4 super(+) CD8 super(+) double-positive stage indicates positive selection by Barthlott, T, Potocnik, A J, Kohler, H, Carsetti, R, Pircher, H, Fowlkes, B J, Eichmann, K

“…We describe a novel mAb (F3) which reacts with a 65 kDa thymocyte surface protein, expressed on similar to 80% of thymocytes, referred to as F3Ag. In ontogeny,…”
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A novel mouse thymocyte antigen (F3Ag): down-regulation during the CD4+CD8+ double-positive stage indicates positive selection by Barthlott, Thomas, Potocnik, Alexandre J., Kohler, Hubertus, Carsetti, Rita, Pircher, Hanspeter, Fowlkes, B. J., Eichmann, Klaus

“…We describe a novel mAb (F3) which reacts with a 65 kDa thymocyte surface protein, expressed on ∼80% of thymocytes, referred to as F3Ag. In ontogeny, F3Ag…”
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