Search Results - "Barthel, Lea"

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis by Schmidt, Eric P, Yang, Yimu, Janssen, William J, Gandjeva, Aneta, Perez, Mario J, Barthel, Lea, Zemans, Rachel L, Bowman, Joel C, Koyanagi, Dan E, Yunt, Zulma X, Smith, Lynelle P, Cheng, Sara S, Overdier, Katherine H, Thompson, Kathy R, Geraci, Mark W, Douglas, Ivor S, Pearse, David B, Tuder, Rubin M

“…The glycocalyx is a layer of proteoglycans and complex carbohydrates that lines the endothelial cell surface in blood vessels. Schmidt et al . show that in…”
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TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension by Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Gebreab, Liya, Robinson, Jeffrey C., Koyanagi, Daniel E., Sanders, Linda, Barthel, Lea, Meadows, Christina, Fox, Daniel, Irwin, David, Li, Min, McKeon, B. Alexandre, Riddle, Suzette, Dale Brown, R., Morgan, Leslie E., Evans, Christopher M., Hernandez-Saavedra, Daniel, Bandeira, Angela, Maloney, James P., Bull, Todd M., Janssen, William J., Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.

“…Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular…”
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Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK by Mohning, Michael P, Thomas, Stacey M, Barthel, Lea, Mould, Kara J, McCubbrey, Alexandria L, Frasch, S Courtney, Bratton, Donna L, Henson, Peter M, Janssen, William J

“…Microparticles are a newly recognized class of mediators in the pathophysiology of lung inflammation and injury, but little is known about the factors that…”
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The transcription elongation factors Spt4 and Spt5 control neural progenitor proliferation and are implicated in neuronal remodeling during Drosophila mushroom body development by Barthel, Lea, Pettemeridi, Stefani, Nebras, Ali, Schnaidt, Hayley, Fahland, Karoline, Vormwald, Lea, Raabe, Thomas

“…Spt4 and Spt5 form the DRB sensitivity inducing factor (DSIF) complex that regulates transcription elongation at multiple steps including promotor-proximal…”
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Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury by JANSSEN, William J, BARTHEL, Lea, MULDROW, Alaina, OBERLEY-DEEGAN, Rebecca E, KEARNS, Mark T, JAKUBZICK, Claudia, HENSON, Peter M

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Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer by Ghosh, Moumita, Dwyer-Nield, Lori D, Kwon, Jennifer B, Barthel, Lea, Janssen, William J, Merrick, Daniel T, Keith, Robert L

“…Squamous cell lung cancer (SCC) is the second leading cause of lung cancer death in the US and has a 5-year survival rate of only 16%. Histological changes in…”
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Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury by Altmann, Christopher, Andres-Hernando, Ana, McMahan, Rachel H, Ahuja, Nilesh, He, Zhibin, Rivard, Chris J, Edelstein, Charles Louis, Barthel, Lea, Janssen, William J, Faubel, Sarah

“…Serum IL-6 is increased in acute kidney injury (AKI) and inhibition of IL-6 reduces AKI-mediated lung inflammation. We hypothesized that circulating monocytes…”
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Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy by Hastings, Michelle L, Berniac, Joel, Liu, Ying Hsiu, Abato, Paul, Jodelka, Francine M, Barthel, Lea, Kumar, Sujatha, Dudley, Caroline, Nelson, Mark, Larson, Kelley, Edmonds, Jason, Bowser, Todd, Draper, Michael, Higgins, Paul, Krainer, Adrian R

“…There is at present no cure or effective therapy for spinal muscular atrophy (SMA), a neurodegenerative disease that is the leading genetic cause of infant…”
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Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis by McCubbrey, Alexandra L, Barthel, Lea, Mohning, Michael P, Redente, Elizabeth F, Mould, Kara J, Thomas, Stacey M, Leach, Sonia M, Danhorn, Thomas, Gibbings, Sophie L, Jakubzick, Claudia V, Henson, Peter M, Janssen, William J

“…Idiopathic pulmonary fibrosis is a progressive lung disease with complex pathophysiology and fatal prognosis. Macrophages (MΦ) contribute to the development of…”
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Development and characterization of a lung-protective method of bone marrow transplantation in the mouse by Janssen, William J., Muldrow, Alaina, Kearns, Mark T., Barthel, Lea, Henson, Peter M.

“…Allogeneic bone marrow transplantation is a common method used to study the contribution of myeloid and lymphoid cell populations in murine models of disease…”
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Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury by Janssen, William J, Barthel, Lea, Muldrow, Alaina, Oberley-Deegan, Rebecca E, Kearns, Mark T, Jakubzick, Claudia, Henson, Peter M

“…During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation…”
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Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury by Mould, Kara J, Barthel, Lea, Mohning, Michael P, Thomas, Stacey M, McCubbrey, Alexandra L, Danhorn, Thomas, Leach, Sonia M, Fingerlin, Tasha E, O'Connor, Brian P, Reisz, Julie A, D'Alessandro, Angelo, Bratton, Donna L, Jakubzick, Claudia V, Janssen, William J

“…Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate…”
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Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice by Neudecker, Viola, Brodsky, Kelley S, Clambey, Eric T, Schmidt, Eric P, Packard, Thomas A, Davenport, Bennett, Standiford, Theodore J, Weng, Tingting, Fletcher, Ashley A, Barthel, Lea, Masterson, Joanne C, Furuta, Glenn T, Cai, Chunyan, Blackburn, Michael R, Ginde, Adit A, Graner, Michael W, Janssen, William J, Zemans, Rachel L, Evans, Christopher M, Burnham, Ellen L, Homann, Dirk, Moss, Marc, Kreth, Simone, Zacharowski, Kai, Henson, Peter M, Eltzschig, Holger K

“…Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to…”
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The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension by Kumar, Rahul, Mickael, Claudia, Chabon, Jacob, Gebreab, Liya, Rutebemberwa, Alleluiah, Garcia, Alexandra Rodriguez, Koyanagi, Daniel E, Sanders, Linda, Gandjeva, Aneta, Kearns, Mark T, Barthel, Lea, Janssen, William J, Mauad, Thais, Bandeira, Angela, Schmidt, Eric, Tuder, Rubin M, Graham, Brian B

“…The etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause of PAH worldwide, is poorly understood. Schistosoma mansoni…”
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Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant by Saleh, Leila S., Amer, Luke D., Thompson, Brittany J., Danhorn, Thomas, Knapp, Jennifer R., Gibbings, Sophie L., Thomas, Stacey, Barthel, Lea, O'Connor, Brian P., Janssen, William J., Alper, Scott, Bryant, Stephanie J.

“…Poly(ethylene glycol) (PEG) hydrogels hold promise for in vivo applications but induce a foreign body response (FBR). While macrophages are key in the FBR,…”
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Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems by McCubbrey, Alexandra L, Barthel, Lea, Mould, Kara J, Mohning, Michael P, Redente, Elizabeth F, Janssen, William J

“…During homeostasis two distinct macrophage (Mø) populations inhabit the lungs: tissue Mø (often called interstitial Mø) and resident alveolar Mø (resAMø)…”
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The STING of inflammation (INM2P.356) by Packard, Thomas, Mohning, Michael, Barthel, Lea, Henson, Peter, Janssen, William, Cambier, John

“…Abstract Stimulator of Interferon Genes (STING, a.k.a. MPYS, TMEM173) is a critical intracellular transducer of innate immune signals induced by cytosolic DNA…”
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Fas ligand-expressing lymphocytes enhance alveolar macrophage apoptosis in the resolution of acute pulmonary inflammation by Kearns, Mark T, Barthel, Lea, Bednarek, Joseph M, Yunt, Zulma X, Henson, Peter M, Janssen, William J

“…Apoptosis of alveolar macrophages and their subsequent clearance by neighboring phagocytes are necessary steps in the resolution of acute pulmonary…”
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Deletion of c-FLIP from CD11b hi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis by McCubbrey, Alexandra L, Barthel, Lea, Mohning, Michael P, Redente, Elizabeth F, Mould, Kara J, Thomas, Stacey M, Leach, Sonia M, Danhorn, Thomas, Gibbings, Sophie L, Jakubzick, Claudia V, Henson, Peter M, Janssen, William J

“…Idiopathic pulmonary fibrosis is a progressive lung disease with complex pathophysiology and fatal prognosis. Macrophages (MΦ) contribute to the development of…”
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Circulating hematopoietic progenitor cells are decreased in COPD by Janssen, William J, Yunt, Zulma X, Muldrow, Alaina, Kearns, Mark T, Kloepfer, Angela, Barthel, Lea, Bratton, Donna L, Bowler, Russell P, Henson, Peter M

“…Bone marrow derived progenitor cells participate in the repair of injured vessels. The lungs of individuals with emphysema have reduced alveolar capillary…”
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