Search Results - "Barth, Nicole D"
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1
Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
Published in Nature communications (07-06-2021)“…Bioorthogonal late-stage diversification of amino acids and peptides bears enormous potential for drug discovery and molecular imaging. Despite major…”
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2
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Published in Angewandte Chemie International Edition (20-05-2019)“…The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by…”
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3
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
Published in Nature communications (12-08-2020)“…Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The…”
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4
Regulation of Apoptotic Cell Clearance During Resolution of Inflammation
Published in Frontiers in pharmacology (13-08-2019)“…Programmed cell death (apoptosis) has an important role in the maintenance of tissue homeostasis as well as the progression and ultimate resolution of…”
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5
The "Phagocytic Synapse" and Clearance of Apoptotic Cells
Published in Frontiers in immunology (04-12-2017)“…Apoptosis and subsequent phagocytic clearance of apoptotic cells is important for embryonic development, maintenance of tissues that require regular cellular…”
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6
A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies
Published in Nature communications (02-05-2022)“…Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur…”
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7
In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF4–CaCO3 Nanoconjugates
Published in Advanced materials (Weinheim) (01-09-2019)“…The development of high‐performance contrast agents in magnetic resonance imaging (MRI) has recently received considerable attention, as they hold great…”
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8
Enzyme‐Activatable Chemokine Conjugates for In Vivo Targeting of Tumor‐Associated Macrophages
Published in Angewandte Chemie International Edition (10-10-2022)“…Increased levels of tumor‐associated macrophages (TAMs) are indicators of poor prognosis in most cancers. Although antibodies and small molecules blocking the…”
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9
Acid‐Resistant BODIPY Amino Acids for Peptide‐Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets
Published in Angewandte Chemie International Edition (08-05-2023)“…The G protein‐coupled kisspeptin receptor (GPR54 or KISS1R) is an important mediator in reproduction, metabolism and cancer biology; however, there are limited…”
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10
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Published in Angewandte Chemie International Edition (26-01-2022)“…The detection and quantification of apoptotic cells is a key process in cancer research, particularly during the screening of anticancer therapeutics and in…”
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11
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
Published in Chemical science (Cambridge) (18-12-2019)“…Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and…”
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12
Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis
Published in The Journal of immunology (1950) (01-11-2018)“…Resolution of the inflammatory response requires coordinated regulation of pro- and anti-inflammatory mediator production, together with clearance of recruited…”
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13
In Vivo Tumor Visualization through MRI Off-On Switching of NaGdF 4 -CaCO 3 Nanoconjugates
Published in Advanced materials (Weinheim) (01-09-2019)“…The development of high-performance contrast agents in magnetic resonance imaging (MRI) has recently received considerable attention, as they hold great…”
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14
Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues
Published in Bioorganic & medicinal chemistry (01-09-2019)“…[Display omitted] Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase…”
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15
Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
Published in Journal of visualized experiments (07-07-2023)“…Metastasis - the systemic spread of cancer - is the leading cause of cancer-related deaths. Although metastasis is commonly thought of as a unidirectional…”
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16
Assessment of Neutrophil Apoptosis
Published in Methods in molecular biology (Clifton, N.J.) (2020)“…The process of neutrophil apoptosis has an important role in the resolution of acute inflammation. Apoptotic cell death is characterized by a coordinated…”
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17
Enzyme‐Activatable Chemokine Conjugates for In Vivo Targeting of Tumor‐Associated Macrophages
Published in Angewandte Chemie (10-10-2022)“…Increased levels of tumor‐associated macrophages (TAMs) are indicators of poor prognosis in most cancers. Although antibodies and small molecules blocking the…”
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Journal Article -
18
Acid‐Resistant BODIPY Amino Acids for Peptide‐Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets
Published in Angewandte Chemie (08-05-2023)“…The G protein‐coupled kisspeptin receptor (GPR54 or KISS1R) is an important mediator in reproduction, metabolism and cancer biology; however, there are limited…”
Get full text
Journal Article -
19
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Published in Angewandte Chemie (26-01-2022)“…The detection and quantification of apoptotic cells is a key process in cancer research, particularly during the screening of anticancer therapeutics and in…”
Get full text
Journal Article -
20
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Published in Angewandte Chemie (20-05-2019)“…The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by…”
Get full text
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