Search Results - "Barth, Jaimie L"

Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer by Lee, Min-Sik, Dennis, Courtney, Naqvi, Insia, Dailey, Lucas, Lorzadeh, Alireza, Ye, George, Zaytouni, Tamara, Adler, Ashley, Hitchcock, Daniel S., Lin, Lin, Hoffman, Megan T., Bhuiyan, Aladdin M., Barth, Jaimie L., Machacek, Miranda E., Mino-Kenudson, Mari, Dougan, Stephanie K., Jadhav, Unmesh, Clish, Clary B., Kalaany, Nada Y.

“…There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA), a highly lethal malignancy with increasing incidence 1 and poor…”
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Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities by Shi, Diana D, Guo, Jimmy A, Hoffman, Hannah I, Su, Jennifer, Mino-Kenudson, Mari, Barth, Jaimie L, Schenkel, Jason M, Loeffler, Jay S, Shih, Helen A, Hong, Theodore S, Wo, Jennifer Y, Aguirre, Andrew J, Jacks, Tyler, Zheng, Lei, Wen, Patrick Y, Wang, Timothy C, Hwang, William L

“…With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial…”
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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy by Chen, Jonathan H., Nieman, Linda T., Spurrell, Maxwell, Jorgji, Vjola, Elmelech, Liad, Richieri, Peter, Xu, Katherine H., Madhu, Roopa, Parikh, Milan, Zamora, Izabella, Mehta, Arnav, Nabel, Christopher S., Freeman, Samuel S., Pirl, Joshua D., Lu, Chenyue, Meador, Catherine B., Barth, Jaimie L., Sakhi, Mustafa, Tang, Alexander L., Sarkizova, Siranush, Price, Colles, Fernandez, Nicolas F., Emanuel, George, He, Jiang, Van Raay, Katrina, Reeves, Jason W., Yizhak, Keren, Hofree, Matan, Shih, Angela, Sade-Feldman, Moshe, Boland, Genevieve M., Pelka, Karin, Aryee, Martin J., Mino-Kenudson, Mari, Gainor, Justin F., Korsunsky, Ilya, Hacohen, Nir

“…The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular ‘immunity hubs’ defined by…”
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Concordance of ASCL1, NEUROD1 and POU2F3 transcription factor‐based subtype assignment in paired tumour samples from small cell lung carcinoma by Denize, Thomas, Meador, Catherine B, Rider, Anna B, Ganci, Maria L, Barth, Jaimie L, Kem, Marina, Mino‐Kenudson, Mari, Hung, Yin P

“…Aims Small cell lung carcinoma (SCLC) can be classified into transcription factor‐based subtypes (ASCL1, NeuroD1, POU2F3). While in‐vitro studies suggest…”
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Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome by Villalba, Julian A, Hilburn, Caroline F, Garlin, Michelle A, Elliott, Grant A, Li, Yijia, Kunitoki, Keiko, Poli, Sergio, Alba, George A, Madrigal, Emilio, Taso, Manuel, Price, Melissa C, Aviles, Alexis J, Araujo-Medina, Milagros, Bonanno, Liana, Boyraz, Baris, Champion, Samantha N, Harris, Cynthia K, Helland, Timothy L, Hutchison, Bailey, Jobbagy, Soma, Marshall, Michael S, Shepherd, Daniel J, Barth, Jaimie L, Hung, Yin P, Ly, Amy, Hariri, Lida P, Turbett, Sarah E, Pierce, Virginia M, Branda, John A, Rosenberg, Eric S, Mendez-Pena, Javier, Chebib, Ivan, Rosales, Ivy A, Smith, Rex N, Miller, Miles A, Rosas, Ivan O, Hardin, Charles C, Baden, Lindsey R, Medoff, Benjamin D, Colvin, Robert B, Little, Brent P, Stone, James R, Mino-Kenudson, Mari, Shih, Angela R

“…The leading cause of death in coronavirus disease 2019 (COVID-19) is severe pneumonia, with many patients developing acute respiratory distress syndrome (ARDS)…”
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Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer by Shiba-Ishii, Aya, Johnson, Ted W, Dagogo-Jack, Ibiayi, Mino-Kenudson, Mari, Johnson, Theodore R, Wei, Ping, Weinrich, Scott L, McTigue, Michele A, Walcott, Makeba A, Nguyen-Phuong, Linh, Dionne, Kristin, Acker, Adam, Kiedrowski, Lesli A, Do, Andrew, Peterson, Jennifer L, Barth, Jaimie L, Yeap, Beow Y, Gainor, Justin F, Lin, Jessica J, Yoda, Satoshi, Hata, Aaron N

“…Lorlatinib is currently the most advanced, potent and selective anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor for the treatment of ALK-positive…”
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Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors by Burr, Risa, Leshchiner, Ignaty, Costantino, Christina L, Blohmer, Martin, Sundaresan, Tilak, Cha, Justin, Seeger, Karsen, Guay, Sara, Danysh, Brian P, Gore, Ira, Jacobs, Raquel A, Slowik, Kara, Utro, Filippo, Rhrissorrakrai, Kahn, Levovitz, Chaya, Barth, Jaimie L, Dubash, Taronish, Chirn, Brian, Parida, Laxmi, Sequist, Lecia V, Lennerz, Jochen K, Mino-Kenudson, Mari, Maheswaran, Shyamala, Naxerova, Kamila, Getz, Gad, Haber, Daniel A

“…Although the development of multiple primary tumors in smokers with lung cancer can be attributed to carcinogen-induced field cancerization, the occurrence of…”
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Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment by Hwang, William L., Jagadeesh, Karthik A., Guo, Jimmy A., Hoffman, Hannah I., Yadollahpour, Payman, Reeves, Jason W., Mohan, Rahul, Drokhlyansky, Eugene, Van Wittenberghe, Nicholas, Ashenberg, Orr, Farhi, Samouil L., Schapiro, Denis, Divakar, Prajan, Miller, Eric, Zollinger, Daniel R., Eng, George, Schenkel, Jason M., Su, Jennifer, Shiau, Carina, Yu, Patrick, Freed-Pastor, William A., Abbondanza, Domenic, Mehta, Arnav, Gould, Joshua, Lambden, Conner, Porter, Caroline B. M., Tsankov, Alexander, Dionne, Danielle, Waldman, Julia, Cuoco, Michael S., Nguyen, Lan, Delorey, Toni, Phillips, Devan, Barth, Jaimie L., Kem, Marina, Rodrigues, Clifton, Ciprani, Debora, Roldan, Jorge, Zelga, Piotr, Jorgji, Vjola, Chen, Jonathan H., Ely, Zackery, Zhao, Daniel, Fuhrman, Kit, Fropf, Robin, Beechem, Joseph M., Loeffler, Jay S., Ryan, David P., Weekes, Colin D., Ferrone, Cristina R., Qadan, Motaz, Aryee, Martin J., Jain, Rakesh K., Neuberg, Donna S., Wo, Jennifer Y., Hong, Theodore S., Xavier, Ramnik, Aguirre, Andrew J., Rozenblatt-Rosen, Orit, Mino-Kenudson, Mari, Castillo, Carlos Fernandez-del, Liss, Andrew S., Ting, David T., Jacks, Tyler, Regev, Aviv

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary…”
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Abstract 94: Multi-compartment reprogramming and spatially-resolved interactions in frozen pancreatic cancer with and without neoadjuvant chemotherapy and radiotherapy at single-cell resolution by Hwang, William L., Jagadeesh, Karthik A., Guo, Jimmy A., Hoffman, Hannah I., Yadollahpour, Payman, Reeves, Jason, Drokhlyansky, Eugene, Van Wittenberghe, Nicholas, Farhi, Samouil, Schapiro, Denis, Eng, George, Schenkel, Jason M., Freed-Pastor, William A., Ashenberg, Orr, Rodrigues, Clifton, Abbondanza, Domenic, Delorey, Toni, Phillips, Devan, Roldan, Jorge, Ciprani, Debora, Kern, Marina, Barth, Jaimie L., Zollinger, Daniel R., Fuhrman, Kit, Fropf, Robin, Beechem, Joseph, Weekes, Colin, Ferrone, Cristina R., Wo, Jennifer Y., Hong, Theodore S., Rozenblatt-Rosen, Orit, Aguirre, Andrew J., Mino-Kenudson, Mari, Fernandez-del- Castillo, Carlos, Liss, Andrew S., Ting, David T., Jacks, Tyler, Regev, Aviv

“…Abstract A molecular classification of pancreatic ductal adenocarcinoma (PDAC) that informs clinical management remains elusive. Previously identified bulk…”
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Abstract 771: Mechanisms of genetic predisposition to multifocal lung cancer by Burr, Risa, Leshchiner, Ignaty, Costantino, Christina L., Blohmer, Martin, Sundaresan, Tilak, Cha, Justin, Seeger, Karsen, Guay, Sara, Danysh, Brian P., Gore, Ira, Jacobs, Raquel A., Slowik, Kara, Utro, Filippo, Rhrissorrakrai, Kahn, Levovitz, Chaya, Barth, Jaimie L., Dubash, Taronish, Chirn, Brian, Parida, Laxmi, Sequist, Lecia V., Mino-Kenudson, Mari, Naxerova, Kamila, Maheswaran, Shyamala, Getz, Gad, Haber, Daniel A.

“…Abstract Detection of multiple primary lung cancers is increasing in frequency, with up to 15% of all non-small cell lung cancer (NSCLC) patients presenting…”
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Abstract 2513: Distinct cancer-intrinsic mechanisms mediate nerve recruitment/outgrowth versus perineural invasion by Hwang, William L., Su, Jennifer, Shiau, Carina, Wang, Peter L., Guo, Jimmy A., Lester, Nicole A., Barth, Jaimie L., Hoffman, Hannah I., Divakar, Prajan, Reeves, Jason W., Miller, Eric, Beechem, Joseph M., Aguirre, Andrew J., Zheng, Lei, Ting, David T., Mino-Kenudson, Mari, Jacks, Tyler

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) features abundant perineural invasion (PNI). Intra-tumoral nerves play critical roles in cancer initiation,…”
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Abstract 7474: T-cell responses across heart, blood, and tumor in patients with immune checkpoint inhibitor-related myocarditis (irMyocarditis) by Blum, Steven, Zlotoff, Daniel A., Smith, Neal P., Kernin, Isabela J., Ramesh, Swetha, Oliveira, Giacomo, Zubiri, Leyre, Caplin, Joshua, Samanta, Nandini, Martin, Sidney, Wang, Mike, Tirard, Alice, Sen, Pritha, Song, Yuhui, Xu, Katherine, Barth, Jaimie L., Slowikowski, Kamil, Nasrallah, Mazen, Tantivit, Jessica, Manakongtreecheep, Kasidet, Arnold, Benjamin Y., McGuire, John, Afeyan, Alexander B., Pinto, Christopher J., McLoughlin, Daniel, Jackson, Monica, Chan, PuiYee, Lawless, Aleigha, Michaud, William A., Sharova, Tatyana, Nieman, Linda T., Gainor, Justin F., Juric, Dejan, Mino-Kenudsen, Mari, Sullivn, Ryan J., Boland, Genevieve M., Stone, James R., Wu, Catherine J., Thomas, Molly F., Neilan, Tomas G., Reynolds, Kerry L., Villani, Alexandra-Chloé

“…Abstract Introduction: Immune checkpoint inhibitor (ICI)-related myocarditis (irMyocarditis) is a potentially lethal complication of ICI use that is…”
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Abstract C052: Identifying mediators of perineural invasion in pancreatic cancer using spatial transcriptomics by Hwang, William L., Su, Jennifer, Guo, Jimmy A., Shiau, Carina, Barth, Jaimie L., Hoffman, Hannah I., Divakar, Prajan, Reeves, Jason W., Miller, Eric, Cervantes-Jaramillo, Grissel, Freed-Pastor, William, Funes, Vanessa, Wo, Jennifer Y., Hong, Theodore S., Castillo, Carlos Fernandez-del, Zheng, Lei, Aguirre, Andrew J., Ting, David T., Mino-Kenudson, Mari, Jacks, Tyler

“…Abstract Intratumoral nerves play important and versatile roles in cancer initiation, progression, recurrence, treatment-resistance, metastasis, morbidity, and…”
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Abstract SY12-04: Multicellular spatial community featuring a novel neuronal-like malignant phenotype is enriched in pancreatic cancer after neoadjuvant chemotherapy and radiotherapy by Hwang, William L., Jagadeesh, Karthik A., Guo, Jimmy A., Hoffman, Hannah I., Shiau, Carina, Su, Jennifer, Yadollahpour, Payman, Reeves, Jason W., Kim, Youngmi, Kim, Sean, Gregory, Mark, Divakar, Prajan, Miller, Eric, Rhodes, Michael, Warren, Sarah, Rueckert, Erroll, Fuhrman, Kit, Zollinger, Daniel R., Fropf, Robin, Beechem, Joseph M., Mehta, Arnav, Delorey, Toni, McCabe, Cristin, Barth, Jaimie L., Zelga, Piotr, Ferrone, Cristina R., Qadan, Motaz, Lillemoe, Keith D., Jain, Rakesh K., Wo, Jennifer Y., Hong, Theodore S., Xavier, Ramnik, Rozenblatt-Rosen, Orit, Aguirre, Andrew J., Castillo, Carlos Fernandez-Del, Liss, Andrew S., Mino-Kenudson, Mari, Ting, David T., Jacks, Tyler, Regev, Aviv

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality in the United States by 2030. Given that…”
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