Comparative study of non-suppurative meningoencephalitis in cattle in Southern Brazil

Comparative study of non-suppurative meningoencephalitis in cattle in Southern Brazil

Viral neurologic diseases are common in cattle, although most non-suppurative meningoencephalitis (NSM) remains etiologically unknown. We compared the epidemiological, clinical, and pathological data among 79 cases of rabies, 12 cases of NSM of unknown etiology (NSM-UE), and 8 cases of herpetic meni...

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Bibliographic Details
Published in:Veterinary research communications Vol. 48; no. 6; pp. 4079 - 4088
Main Authors: Barbosa, Francisca Maria Sousa, dos Santos, Igor Ribeiro, de Almeida, Bruno Albuquerque, Molossi, Franciéli Adriane, de Almeida, Paula Rodrigues, Lamego, Eryca Ceolin, Barth, Júlia Camargo, Simões, Sara Vilar Dantas, Panziera, Welden, Sonne, Luciana, Pavarini, Saulo Petinatti, Driemeier, David
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-12-2024
Springer Nature B.V
Subjects:
Astrocytes
Biomedical and Life Sciences
Brief Report
Cattle
Cell number
Central nervous system
Epidemiology
Gliosis
Hemorrhage
Immunohistochemistry
Leukocytes (eosinophilic)
Life Sciences
Lymphocytes
Lymphocytes B
Lymphocytes T
Macrophages
Meningoencephalitis
Microglia
Neurological diseases
Neuropil
Plasma cells
Rabies
Statistical analysis
Veterinary Medicine/Veterinary Science
Viral diseases
Zoology
Brazil
Encephalitis
Livestock
Herpetic meningoencephalitis
Neuropathology
Rabies
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Summary:Viral neurologic diseases are common in cattle, although most non-suppurative meningoencephalitis (NSM) remains etiologically unknown. We compared the epidemiological, clinical, and pathological data among 79 cases of rabies, 12 cases of NSM of unknown etiology (NSM-UE), and 8 cases of herpetic meningoencephalitis previously diagnosed in cattle in Southern Brazil. Neurological clinical signs were similar among rabies and NSM-UE and different in cattle with herpetic meningoencephalitis. Only two herpetic meningoencephalitis cases had gross lesions in the central nervous system, characterized by malacia and hemorrhage. Histologically, all three groups had mild to severe multifocal infiltrates of lymphocytes, plasma cells, and macrophages/microglial cells in the Virchow-Robin space, neuropil, and leptomeninges, and gliosis. Other findings included malacia and eosinophilic intracytoplasmic inclusion in rabies, and malacia and intranuclear amphophilic inclusion in herpetic meningoencephalitis. By immunohistochemistry, the predominant inflammatory cells in all cases were T lymphocytes, followed by macrophages/microglial cells, B lymphocytes, and astrocytes. The T lymphocyte count showed statistically significant differences between the diseases. Our results revealed few differences between the groups. Although the etiological agent involved has not been identified in cases of NSM-UE, the characteristics observed in this study showed similarity with viral diseases.
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ISSN:0165-7380
1573-7446
1573-7446
DOI:10.1007/s11259-024-10524-8