Search Results - "Barth, Brian"

Ceramide: improving Bcl-2 inhibitor therapy by Barth, Brian M

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Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria by Belknap, Kaitlyn C., Park, Cooper J., Barth, Brian M., Andam, Cheryl P.

“…Streptomyces bacteria are known for their prolific production of secondary metabolites, many of which have been widely used in human medicine, agriculture and…”
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin by Scherer, Philipp E, Holland, William L, Miller, Russell A, Wang, Zhao V, Sun, Kai, Barth, Brian M, Bui, Hai H, Davis, Kathryn E, Bikman, Benjamin T, Halberg, Nils, Rutkowski, Joseph M, Wade, Mark R, Tenorio, Vincent M, Kuo, Ming-Shang, Brozinick, Joseph T, Zhang, Bei B, Birnbaum, Morris J, Summers, Scott A

“…The protein hormone adiponectin is known to have many beneficial systemic effects, including promoting cell survival, anti-inflammation and insulin…”
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Near-Infrared Emitting Fluorophore-Doped Calcium Phosphate Nanoparticles for In Vivo Imaging of Human Breast Cancer by Altınoǧlu, Erhan I˙, Russin, Timothy J, Kaiser, James M, Barth, Brian M, Eklund, Peter C, Kester, Mark, Adair, James H

“…Early detection is a crucial element for the timely diagnosis and successful treatment of all human cancers but is limited by the sensitivity of current…”
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Ceramide-based therapeutics for the treatment of cancer by Barth, Brian M, Cabot, Myles C, Kester, Mark

“…The bioactive sphingolipid, ceramide, has garnered major interest as a principle regulator of cellular stress, proliferation, senescence, and death. Of…”
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Microemulsions as Emerging Electrolytes: The Correlation of Structure to Electrochemical Response by Imel, Adam E, Barth, Brian, Hayes, Douglas G, Dadmun, Mark, Zawodzinski, Thomas

“…We describe the structural studies of microemulsions (μEs) prepared from water, toluene, butanol, and polysorbate 20 (PS20) that we recently used as…”
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Sphingolipids as Regulators of Neuro-Inflammation and NADPH Oxidase 2 by Arsenault, Emma J., McGill, Colin M., Barth, Brian M.

“…Neuro-inflammation accompanies numerous neurological disorders and conditions where it can be associated with a progressive neurodegenerative pathology. In a…”
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Targeted Indocyanine-Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia by Barth, Brian M, I. Altinoğlu, Erhan, Shanmugavelandy, Sriram S, Kaiser, James M, Crespo-Gonzalez, Daniza, DiVittore, Nicole A, McGovern, Christopher, Goff, Trevor M, Keasey, Nicole R, Adair, James H, Loughran, Thomas P, Claxton, David F, Kester, Mark

“…Leukemia is one of the most common and aggressive adult cancers, as well as the most prevalent childhood cancer. Leukemia is a cancer of the hematological…”
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Microemulsions: Breakthrough Electrolytes for Redox Flow Batteries by Barth, Brian A, Imel, Adam, Nelms, K McKensie, Goenaga, Gabriel A, Zawodzinski, Thomas

“…Aqueous and non-aqueous redox flow batteries (RFBs) have limited energy and current densities, respectively, due to the nature of the electrolytes. New…”
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Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α by Barth, Brian M., Gustafson, Sally J., Kuhn, Thomas B.

“…Inflammation accompanied by severe oxidative stress plays a vital role in the orchestration and progression of neurodegeneration prevalent in chronic and acute…”
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Ceramide 1-Phosphate Mediates Endothelial Cell Invasion via the Annexin a2-p11 Heterotetrameric Protein Complex by Hankins, Jody L., Ward, Katherine E., Linton, Sam S., Barth, Brian M., Stahelin, Robert V., Fox, Todd E., Kester, Mark

“…The bioactive sphingolipid, ceramide 1-phosphate (C-1-P), has been implicated as an extracellular chemotactic agent directing cellular migration in…”
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Bioconjugation of Calcium Phosphosilicate Composite Nanoparticles for Selective Targeting of Human Breast and Pancreatic Cancers In Vivo by Barth, Brian M, Sharma, Rahul, Altınoǧlu, Erhan İ, Morgan, Thomas T, Shanmugavelandy, Sriram S, Kaiser, James M, McGovern, Christopher, Matters, Gail L, Smith, Jill P, Kester, Mark, Adair, James H

“…The early diagnosis of cancer is the critical element in successful treatment and long-term favorable patient prognoses. The high rate of mortality is mainly…”
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Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression by Hankins, Jody L., Fox, Todd E., Barth, Brian M., Unrath, Kellee A., Kester, Mark

“…Toll-like receptor 4 (TLR4) is a component of the innate immune system that recognizes a diverse group of molecular structures, such as lipopolysaccharide…”
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Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia—Impact on enzyme activity and response to cytotoxics by Morad, Samy A.F., Tan, Su-Fern, Feith, David J., Kester, Mark, Claxton, David F., Loughran, Thomas P., Barth, Brian M., Fox, Todd E., Cabot, Myles C.

“…The triphenylethylene antiestrogen, tamoxifen, can be an effective inhibitor of sphingolipid metabolism. This off-target activity makes tamoxifen an…”
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Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma by Tagaram, Hephzibah Rani S, Divittore, Nicole A, Barth, Brian M, Kaiser, James M, Avella, Diego, Kimchi, Eric T, Jiang, Yixing, Isom, Harriet C, Kester, Mark, Staveley-O'Carroll, Kevin F

“…Hepatocellular carcinoma (HCC) affects an increasing number of people worldwide. The poor survival rate of patients with HCC is manifested by an aggressive and…”
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Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression by Doi, Kenichiro, Liu, Qiang, Gowda, Krishne, Barth, Brian M, Claxton, David, Amin, Shantu, Loughran Jr, Thomas P, Wang, Hong-Gang

“…Acute myeloid leukemia (AML) is one of the deadliest leukemias for which there is an urgent and unmet need for the development of novel treatment strategies…”
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Cholecystokinin Mediates Progression and Metastasis of Pancreatic Cancer Associated with Dietary Fat by Matters, Gail L., Cooper, Timothy K., McGovern, Christopher O., Gilius, Evan L., Liao, Jiangang, Barth, Brian M., Kester, Mark, Smith, Jill P.

“…Background Obesity and dietary fat are associated with increased risk of several malignancies including pancreatic cancer. The incidence of pancreatic cancer…”
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Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia by Morad, Samy A F, Ryan, Terence E, Neufer, P Darrell, Zeczycki, Tonya N, Davis, Traci S, MacDougall, Matthew R, Fox, Todd E, Tan, Su-Fern, Feith, David J, Loughran, Jr, Thomas P, Kester, Mark, Claxton, David F, Barth, Brian M, Deering, Tye G, Cabot, Myles C

“…The objective of our study was to determine the mechanism of action of the short-chain ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen,…”
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Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia by McGill, Colin M., Tomco, Patrick L., Ondrasik, Regina M., Belknap, Kaitlyn C., Dwyer, Gaelen K., Quinlan, Daniel J., Kircher, Thomas A., Andam, Cheryl P., Brown, Timothy J., Claxton, David F., Barth, Brian M.

“…Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is one of the more common pediatric malignancies in addition to occurring with high…”
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Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer by Jiang, Yixing, DiVittore, Nicole A., Kaiser, James M., Shanmugavelandy, Sriram S., Fritz, Jennifer L., Heakal, Yasser, Tagaram, Hephzibah Rani S., Cheng, Hua, Cabot, Myles C., Staveley-O'Carroll, Kevin F., Tran, Melissa A., Fox, Todd E., Barth, Brian M., Kester, Mark

“…Poor prognosis cancers, such as pancreatic cancer, represent inherent challenges for ceramide-based nanotherapeutics due to metabolic pathways, which…”
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