Search Results - "Bartfai, T."

Galanin, galanin receptors and drug targets by Mitsukawa, K, Lu, X, Bartfai, T

“…Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous…”
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Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine by CONTI, B, MAIER, R, BARR, A. M, MORALE, M. C, LU, X, SANNA, P. P, BILBE, G, HOYER, D, BARTFAI, T

“…The significant proportion of depressed patients that are resistant to monoaminergic drug therapy and the slow onset of therapeutic effects of the selective…”
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Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases by Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., Marinovich, M.

“…Interleukin (IL)-1β is a proinflammatory cytokine implicated in various pathophysiological conditions of the CNS involving NMDA receptor activation…”
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IL-1/IL-1ra balance in the brain revisited – Evidence from transgenic mouse models by Spulber, S, Bartfai, T, Schultzberg, M

“…Abstract The interleukin-1 (IL-1) family is unique in its including an endogenous antagonist of the IL-1 receptor (IL-1ra). IL-1ra has been shown to antagonise…”
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Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity by Osborn, O., Brownell, S.E., Sanchez-Alavez, M., Salomon, D., Gram, H., Bartfai, T.

“…The proinflammatory cytokine Interleukin 1 beta (IL-1β) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion,…”
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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis by Pepys, M. B, Herbert, J, Hutchinson, W. L, Tennent, G. A, Lachmann, H. J, Gallimore, J. R, Lovat, L. B, Bartfai, T, Alanine, A, Hertel, C, Hoffmann, T, Jakob-Roetne, R, Norcross, R. D, Kemp, J. A, Yamamura, K, Suzuki, M, Taylor, G. W, Murray, S, Thompson, D, Purvis, A, Kolstoe, S, Wood, S. P, Hawkins, P. N

“…The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of amyloid deposits, and contributes to the pathogenesis of…”
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Powerful Anticonvulsant Action of IL-1 Receptor Antagonist on Intracerebral Injection and Astrocytic Overexpression in Mice by Vezzani, A., Moneta, D., Conti, M., Richichi, C., Ravizza, T., De Luigi, A., De Simoni, M. G., Sperk, G., Andell-Jonsson, S., Lundkvist, J., Iverfeldt, K., Bartfai, T.

“…IL-1β and its endogenous receptor antagonist (IL-1Ra) are rapidly induced by seizures in the rodent hippocampus. Exogenously applied IL-1β prolongs seizures in…”
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Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats by Kovács, Z., Kékesi, K.A., Szilágyi, N., Ábrahám, I., Székács, D., Király, N., Papp, E., Császár, I., Szegő, É., Barabás, K., Péterfy, H., Erdei, A., Bártfai, T., Juhász, G.

“…In normal rats the proinflammatory cytokines like interleukin-1β, interleukin-6, which are induced by bacterial lipopolysaccharides, are able to control…”
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Interleukin-1β induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons by Tabarean, I.V., Korn, H., Bartfai, T.

“…Most of the inflammatory effects of the cytokine interleukin 1β (IL-1β) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and…”
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Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge by Zorrilla, E.P, Brennan, M, Sabino, V, Lu, X, Bartfai, T

“…Abstract Galanin, a brain and pancreatic peptide with three receptor subtypes (GALR1, GALR2, and GALR3), is hypothesized to participate in energy homeostasis…”
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Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice by Chai, Z, Gatti, S, Toniatti, C, Poli, V, Bartfai, T

“…Interleukin (IL)-6, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) are considered to act as endogenous pyrogens. Because of the complex pattern of…”
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Bidirectional regulation of stress responses by galanin in mice: Involvement of galanin receptor subtype 1 by Mitsukawa, K, Lu, X, Bartfai, T

“…Abstract The neuropeptide galanin has been shown to play a role in psychiatric disorders as well as in other biological processes including regulation of pain…”
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Telling the brain about pain by Bartfai, Tamas

“…Injury to one part of the body often results in hypersensitivity to pain somewhere else. Unusually, this process seems to be coordinated by the brain in a way…”
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Pharmacogenomics in drug development: societal and technical aspects by Bartfai, T

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Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6 by Gatti, S, Bartfai, T

“…The constitutive expression of tumor necrosis factor-alpha (TNF alpha) mRNA and its induction (60 min later) by peripheral injection of Escherichia coli…”
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Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice by Mazarati, A., Lu, X., Shinmei, S., Badie-Mahdavi, H., Bartfai, T.

“…The neuropeptide galanin exhibits anticonvulsant effects in experimental epilepsy. Two galanin receptor subtypes, GalR1 and GalR2, are present in the brain. We…”
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Cellular translocation of proteins by transportan by Pooga, Margus, Kut, Cecilia, Kihlmark, Madeleine, Hällbrink, Mattias, Fernaeus, Sandra, Raid, Raivo, Land, Tiit, Hallberg, Einar, Bartfai, Tamas, Langel, Ülo

“…ABSTRACT Proteins with molecular masses ranging from 30 kDa (green fluorescent protein, GFP) to 150 kDa (monoclonal and polyclonal antibodies) were coupled to…”
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Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment by Sugama, S., Wirz, S.A., Barr, A.M., Conti, B., Bartfai, T., Shibasaki, T.

“…Recent reports have revealed an involvement of microglial cells in dopaminergic neurodegeneration. In the present study, we tested the hypothesis that…”
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Galanin, galanin receptors, and drug targets by Mitsukawa, K, Lu, X, Bartfai, T

“…Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous…”
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Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture by Tabarean, I.V., Conti, B., Behrens, M., Korn, H., Bartfai, T.

“…Responses of mouse preoptic and anterior hypothalamic neurons to variations of temperature are key elements in regulating the setpoint of homeotherms. The goal…”
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