Search Results - "Barten, M J"

Sotrastaurin, a Novel Small Molecule Inhibiting Protein Kinase C: First Clinical Results in Renal‐Transplant Recipients by Budde, K., Sommerer, C., Becker, T., Asderakis, A., Pietruck, F., Grinyo, J. M., Rigotti, P., Dantal, J., Ng, J., Barten, M. J., Weber, M.

“…Sotrastaurin, a novel protein‐kinase‐C inhibitor, blocks early T‐cell activation. In this 12‐month, Phase II study, de novo renal‐transplant patients were…”
Get full text

Immunological monitoring of extracorporeal photopheresis after heart transplantation by Dieterlen, M.‐T., Bittner, H. B., Pierzchalski, A., Dhein, S., Mohr, F. W., Barten, M. J.

“…Summary Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation…”
Get full text

Mediastinitis and cardiac surgery--an updated risk factor analysis in 10,373 consecutive adult patients by Gummert, J F, Barten, M J, Hans, C, Kluge, M, Doll, N, Walther, T, Hentschel, B, Schmitt, D V, Mohr, F W, Diegeler, A

“…Deep sternal wound infection (DSWI) remains a serious complication after cardiac surgery. New evolving techniques including the utilization of internal mammary…”
Get more information

Long-Term Results of Everolimus on Renal Function and Rejection after Heart Transplantation in a Real-Life Scenario by Barten, M.J., Hong, J., Hua, X., Bernhardt, A., Rybczynski, M., Reichenspurner, H.

“…Clinical study results are still controversial about the start of everolimus (ERL) with and without calcineurin inhibitor (CNI) after heart transplantation…”
Get full text

Optimal Dosing of Cyclosporine and Tacrolimus to Improve Medication Adherence after Heart Transplantation by Barten, M.J., Hua, X., Bernhardt, A., Rybczynski, M., Reichenspurner, H.

“…The number of daily tablets is shown to be crucial for medical adherence of patients after heart transplantation (HTx) to improve long-term outcome. In this…”
Get full text

Impact of diabetes mellitus on cardiac surgery outcome by Bucerius, J, Gummert, J F, Walther, T, Doll, N, Falk, V, Onnasch, J F, Barten, M J, Mohr, F W

“…Diabetes mellitus is an established independent risk factor related to significant morbidity and mortality after cardiac surgical procedures. Data on 16,184…”
Get more information

Pharmacodynamic Monitoring of the Conversion of Cyclosporine to Tacrolimus in Heart and Lung Transplant Recipients by Barten, M.J., Rahmel, A., Garbade, J., Bold, A., Bittner, H.B., Dhein, S., Mohr, F.W., Gummert, J.F.

“…Conversion from cyclosporine (CsA) to tacrolimus (TRL) remains challenging in the daily routine due to individual variations in blood concentrations…”
Get full text

C0h/C2h monitoring of the pharmacodynamics of cyclosporin plus mycophenolate mofetil in human heart transplant recipients by BARTEN, M. J, RAHMEL, A, GARBADE, J, RICHTER, M, BITTNER, H. B, DHEIN, S, MOHR, F. W, GUMMERT, J. F

“…Pharmacokinetic (PK) parameters like C2h have improved efficacy of immunosuppressive therapy. However, drug interactions, toxicities, and individual…”
Get full text

Assessment of immunosuppression by lymphocyte functions in human blood by Barten, M.J, Rahmel, A, Chang, H, Tarnok, A, Gehlhaar, P, Dhein, S, Gummert, J.F

Get full text

Pharmacodynamics of T-cell function for monitoring immunosuppression by Barten, M. J., Tarnok, A., Garbade, J., Bittner, H. B., Dhein, S., Mohr, F. W., Gummert, J. F.

“…  Objectives: Recent studies show that measuring pharmacodynamic (PD) effects offers a unique possibility to predict immunosuppression. Thus, in this study we…”
Get full text

Pharmacodynamics of the immunosuppressive effects of the combination of tacrolimus with mycophenolate mofetil by Barten, M.J, Rahmel, A, Richter, M, Tarnok, A, Bartsch, P, Boeger, M, Gehlhaar, P, Dhein, S, Mohr, F.W, Gummert, J.F

Get full text

Pharmacodynamics of sirolimus and cyclosporine combination therapy by Barten, M.J, Rahmel, A, Boeger, M, Bartsch, P, Tarnok, A, Gehlhaar, P, Dhein, S, Mohr, F.W, Gummert, J.F

Get full text

New mechanisms of action of mycophenolate mofetil in transplant recipients by assessment of its pharmacodynamics by Barten, M.J, van Gelder, T, Gummert, J.F, Shorthouse, R, Boeke, K, Billingham, M.E, Morris, R.E

Get full text

Assessment of mechanisms of action of immunosuppressive drugs using novel whole blood assays by Barten, M.J, Gummert, J.F, van Gelder, T, Shorthouse, R, Morris, R.E

Get full text

Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid by VAN GELDER, Teun, KLUPP, Jochen, BARTEN, Markus J, CHRISTIANST, Uwe, MORRIS, Randall E

“…Mycophenolate mofetil (MMF) is almost completely absorbed from the gut and is rapidly de-esterified into its active drug, mycophenolic acid (MPA). The main…”
Get full text

Effect of Anesthesia on a Whole Blood Lymphocyte Proliferation Assay in the Rat by Gummed, Jan F., Otto, Glen, Barten, Markus J., Morris, Randall E.

“…Abstract Lymphocyte proliferation assays are commonly used to quantify the effects of immunosuppressive drugs in animal models, but the influence of anesthetic…”
Get full text

Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro by Barten, Markus J, Gummert, Jan F, van Gelder, Teun, Shorthouse, Randi, Morris, Randall E

“…We have optimized assays to measure mitogen-stimulated rat lymphocyte activation in whole blood and have used these assays to quantitate the potencies of…”
Get full text

Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics by Gummert, J F, Barten, M J, Sherwood, S W, van Gelder, T, Morris, R E

“…Mechanisms of immunosuppressive action of mycophenolic acid (MPA) on rat lymphocytes and correlations among MPA plasma concentrations (pharmacokinetics) and…”
Get more information

Pharmacodynamics of mycophenolic acid in heart allograft recipients: Correlation of lymphocyte proliferation and activation with pharmacokinetics and graft histology by GUMMERT, Jan F, BARTEN, Markus J, VAN GELDER, Teun, BILLINGHAM, Margaret E, MORRIS, Randall E

“…Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions…”
Get full text

High Negative Predictive Value of Cardiac Magnetic Resonance Imaging in Sub-Clinical Acute Cellular Rejection after Heart Transplantation: 2089 by Barten, M. J., Hildebrand, L., Krieghoff, C., Garbade, J., Mohr, F. W., Gutberlet, M.

Get full text