SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions

•COco is a prospective cohort study conducted in the Netherlands, 2020-2021.•We evaluated a population of non-medical contact professions with regular re-exposure to SARS-CoV-2.•COco evaluates the dynamics of antibody levels after exposure to SARS-CoV-2.•Very low seroreversion rates were found, sugg...

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Bibliographic Details
Published in:	International journal of infectious diseases Vol. 126; pp. 155 - 163
Main Authors:	Mioch, Dymphie, Vanbrabant, Leonard, Reimerink, Johan, Kuiper, Sandra, Lodder, Esther, van den Bijllaardt, Wouter, Kluytmans, Jan, Wissing, Michel D., Augustijn, Hans, Bartels, Marit, van Jaarsveld, Cornelia H.M., Leemans, Manon, van Nierop, Peter, van Riet, Natascha, Raaijmakers, Lieke, Reisiger, Els, Reusken, Chantal, Rietveld, Ariene, Salewicz, Sandra
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01-01-2023 Elsevier
Subjects:	Antibodies, Viral Cohort study Contact profession COVID-19 COVID-19 serological testing Humans Immunoglobulin G Natural infection Prospective Studies SARS-CoV-2 SARS-CoV-2 antibodies Contact profession COVID-19 serological testing SARS-CoV-2 antibodies Cohort study Immunoglobulin G Natural infection
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Summary:	•COco is a prospective cohort study conducted in the Netherlands, 2020-2021.•We evaluated a population of non-medical contact professions with regular re-exposure to SARS-CoV-2.•COco evaluates the dynamics of antibody levels after exposure to SARS-CoV-2.•Very low seroreversion rates were found, suggesting long-term natural immunity.•Immunoglobulin G antibody levels initially decreased but remained detectable for up to 12 months. This study aimed to evaluate dynamics of antibody levels after exposure to SARS-CoV-2 for 12 months in Dutch non-vaccinated hairdressers and hospitality staff. In this prospective cohort study, blood samples were collected every 3 months for 1 year and analyzed using a qualitative total antibody enzyme-linked immunosorbent assay (ELISA) and a quantitative immunoglobulin (Ig)G antibody ELISA. Participants completed questionnaires, providing information on demographics, health, and work. Differences in antibody levels were evaluated using Mann–Whitney U and Wilcoxon signed-rank tests. Beta coefficients (β) and 95% confidence intervals (CIs) were calculated using linear regression. Ninety-five of 497 participants (19.1%) had ≥1 seropositive measurement before their last visit using the qualitative ELISA. Only 2.1% (2/95) seroreverted during follow-up. Of 95 participants, 82 (86.3%) tested IgG seropositive in the quantitative ELISA too. IgG antibody levels significantly decreased in the first months (P <0.01) but remained detectable for up to 12 months in all participants. Older age (β, 10-years increment: 24.6, 95% CI: 5.7-43.5) and higher body mass index (β, 5kg/m² increment: 40.0, 95% CI: 2.9-77.2) were significantly associated with a higher peak of antibody levels. In this cohort, SARS-CoV-2 antibodies persisted for up to 1 year after initial seropositivity, suggesting long-term natural immunity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2022.11.025