Search Results - "Bartels, J. Michael"

A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: Development and validation by Smith, Jordan Ned, Hinderliter, Paul M., Timchalk, Charles, Bartels, Michael J., Poet, Torka S.

“…•A life-stage PBPK/PD model for chlorpyrifos was developed.•Simulations predict adults will have higher chlorpyrifos levels in blood.•At doses ⩾0.6mg/kg,…”
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In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma by NED SMITH, Jordan, TIMCHALK, Charles, BARTELS, Michael J, POET, Torka S

“…Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 days to 75 years) and plasma…”
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Direct quantitation of hydroxyethylvaline in hemoglobin by liquid chromatography/positive electrospray tandem mass spectrometry by Zhang, Fagen, Brzak, Kathy A., Pottenger, Lynn H., Bartels, Michael J.

“…► We developed a rapid LC/MS–MS quantitation method for hydroxyvaline in globin. ► This method gave similar hydroxyvaline values compared to the traditional…”
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Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU by Pottenger, Lynn H., Schisler, Melissa R., Zhang, Fagen, Bartels, Michael J., Fontaine, Donald D., McFadden, Lisa G., Bhaskar Gollapudi, B.

“…The dose–response relationships for in vitro mutagenicity induced by methylmethanesulfonate (MMS) or methylnitrosourea (MNU) in L5178Y mouse lymphoma (ML)…”
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Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos by Hinderliter, Paul M., Price, Paul S., Bartels, Michael J., Timchalk, Charles, Poet, Torka S.

“…► Source-to-outcome model for inter-individual variation at dietary dose levels. ► Differences in physiology and variation in metabolism included at ages 3 and…”
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The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data by Lowe, Ezra R., Poet, Torka S., Rick, David L., Marty, M. Sue, Mattsson, Joel L., Timchalk, Charles, Bartels, Michael J.

“…Lipophilic molecules, like chlorpyrifos (CPF), present a special problem for interpretation of biomonitoring data because both the environmental dose of CPF…”
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Biomonitoring of 2,4-Dichlorophenoxyacetic Acid Exposure and Dose in Farm Families by Alexander, Bruce H., Mandel, Jack S., Baker, Beth A., Burns, Carol J., Michael J. Bartels, Acquavella, John F., Gustin, Christophe

“…Objective: We estimated 2,4-dichlorophenoxyacetic acid (2,4-D) exposure and systemic dose in farm family members following an application of 2,4-D on their…”
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Social Exclusion Decreases Prosocial Behavior by Twenge, Jean M, Baumeister, Roy F, DeWall, C. Nathan, Ciarocco, Natalie J, Bartels, J. Michael

“…In 7 experiments, the authors manipulated social exclusion by telling people that they would end up alone later in life or that other participants had rejected…”
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Dynamic Changes in Lipids and Proteins of Maternal, Fetal, and Pup Blood and Milk during Perinatal Development in CD and Wistar Rats by McMullin, Tami S., Lowe, Ezra R., Bartels, Michael J., Marty, Mary Sue

“…An understanding of the physiological factors that regulate perinatal dosimetry is essential to improve the ability of physiologically based (PB)…”
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Quantitation of 4,4'-methylene diphenyl diisocyanate human serum albumin adducts by Luna, Leah G, Green, Brett J, Zhang, Fagen, Arnold, Scott M, Siegel, Paul D, Bartels, Michael J

“…4,4'-Methylene diphenyl diisocyanate (herein 4,4'-MDI) is used in the production of polyurethane foams, elastomers, coatings, adhesives and the like for a wide…”
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Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice by Bartels, Michael J, Hackett, Michael J, Himmelstein, Matthew W, Green, John W, Walker, Carl, Terry, Claire, Rasoulpour, Reza, Challender, Mary, Yan, Zhongyu (June)

“…Abstract 1,3-Dichloropropene (1,3-D) showed a statistically increased incidence of bronchioloalveolar adenomas in male B6C3F1 mice at 60 ppm air concentration…”
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Letter to the editor regarding Heringa et al. (2020) paper entitled “Use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management” by Terry, Claire, Domoradzki, Jeanne Y., Fleming, Carrie R., Gehen, Sean C., Mingoia, Robert T., Murphy, Lynea A., Bartels, Michael J.

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Acute Toxicity Prediction in Multiple Species by Leveraging Mechanistic ToxCast Mitochondrial Inhibition Data and Simulation of Oral Bioavailability by Bhhatarai, Barun, Wilson, Daniel M, Bartels, Michael J, Chaudhuri, Shubhra, Price, Paul S, Carney, Edward W

“…There is great interest in assessing the in vivo toxicity of chemicals using nonanimal alternatives. However, acute mammalian toxicity is not adequately…”
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Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment by Troutman, John A., Rick, David L., Stuard, Sharon B., Fisher, Jeffrey, Bartels, Michael J.

“…2-Phenoxyethanol (PhE) has been shown to induce hepatotoxicity, renal toxicity, and hemolysis at dosages ≥ 400 mg/kg/day in subchronic and chronic studies in…”
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PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data by Cooper, Alexander B., Aggarwal, Manoj, Bartels, Michael J., Morriss, Alistair, Terry, Claire, Lord, Gwyn A., Gant, Timothy W.

“…Physiologically-based toxicokinetic (PBTK) models are mathematical representations of chemical absorption, distribution, metabolism and excretion (ADME) in…”
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Chlorpyrifos PBPK/PD model for multiple routes of exposure by Poet, Torka S., Timchalk, Charles, Hotchkiss, Jon A., Bartels, Michael J.

“…Abstract 1. Chlorpyrifos (CPF) is an important pesticide used to control crop insects. Human Exposures to CPF will occur primarily through oral exposure to…”
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Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos by Poet, Torka S., Timchalk, Charles, Bartels, Michael J., Smith, Jordan N., McDougal, Robin, Juberg, Daland R., Price, Paul S.

“…A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model combined with Monte Carlo analysis of inter-individual variation was used to assess…”
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Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU by Ji, Zhiying, LeBaron, Matthew J, Schisler, Melissa R, Zhang, Fagen, Bartels, Michael J, Gollapudi, B Bhaskar, Pottenger, Lynn H

“…The nature of the dose-response relationship for various in vivo endpoints of exposure and effect were investigated using the alkylating agents, methyl…”
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Guidelines for the derivation of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop by Hays, Sean M., Aylward, Lesa L., LaKind, Judy S., Bartels, Michael J., Barton, Hugh A., Boogaard, Peter J., Brunk, Conrad, DiZio, Stephen, Dourson, Michael, Goldstein, Daniel A., Lipscomb, John, Kilpatrick, Michael E., Krewski, Daniel, Krishnan, Kannan, Nordberg, Monica, Okino, Miles, Tan, Yu-Mei, Viau, Claude, Yager, Janice W.

“…Biomonitoring Equivalents (BEs) are defined as the concentration of a chemical (or metabolite) in a biological medium (blood, urine, human milk, etc.)…”
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Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing – An integrated approach without additional animal use by Saghir, Shakil A., Bartels, Michael J., Rick, David L., McCoy, Alene T., Rasoulpour, Reza J., Ellis-Hutchings, Robert G., Sue Marty, M., Terry, Claire, Bailey, Jason P., Billington, Richard, Bus, James S.

“…► Detailed procedure for implementing TK in short- and long-term toxicity studies. ► Define kinetically-derived maximum doses (KMD). ► Use of KMD and MTD to…”
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