Search Results - "Barsoumian, H."

Low-Dose Radiation Decreases Cancer-Associated Fibroblasts and May Increase T-Cell Trafficking into Tumors by Patel, R.R., Barsoumian, H., Verma, V., Cortez, M.A., Welsh, J.W.

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SHP-2 and PDL1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD1-resistant Model of Non-small-cell-lung Cancer by Chen, D., Barsoumian, H., Yang, L., Younes, A., Verma, V., Cortez, M.A., Welsh, J.W.

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Combination Treatment With Radiotherapy And A Novel Oxidative Phosphorylation Inhibitor Overcomes PD-1 Resistance And Enhances Antitumor Immunity by Chen, D., Barsoumian, H., Fisher, G., Yang, L., Vellano, C., Marszalek, J., Davies, M., Cortez, M.A., Welsh, J.W.

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Senolytic Cocktail Dasatinib Plus Quercetin Enhances the Antitumor Effect of Senescence-Inducing Radiotherapy in a Preclinical Model of Melanoma by He, K., Barsoumian, H.B., Yang, L., Sezen, D., Wasley, M.D., Masrorpour, F., Cortez, M.A., Welsh, J.W.

“…Although radiation is beneficial in killing tumor cells, it also causes accumulation of senescent cells in tumors and in the surrounding healthy tissue…”
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Comparison of Low vs. High Dose Radiation to Reduce Intratumoral Pressure, Creating an Optimal Time Window for Drug Delivery by Ramapriyan, R., Sezen, D., Barsoumian, H.B., Crowley, K., Cortez, M.A., Welsh, J.W.

“…Intratumoral pressure creates a major barrier for delivery and retention of immuno-oncology drugs, such as checkpoint inhibitors. A strong pressure…”
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NBTXR3 Nanoparticle With Immunoradiation Might Reshape Metastatic Tumor-Infiltrating T Cell Repertoire in Murine Lung Cancer Model by Abana, C.O., Hu, Y., Paris, S., Barsoumian, H.B., Gandhi, S., Nguyen, Q.N., Cortez, M.A., Welsh, J.W.

“…Radiation therapy (XRT) induces lymphocyte infiltration of primary tumors that is increased when using NBTXR3 radioenhancer nanoparticle, leading to improved…”
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Anti-GITR with Radiation Therapy Enhances Anti-Tumor Abscopal Effects in Anti-PD1 Resistant Murine Model by Cushman, T.R., Schoenhals, J., Barsoumian, H., Caetano, M.D.S., Cadena, A., Younes, A., Li, A., Niknam, S., Cortez, M.A., Welsh, J.W.

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Low Dose Radiation Improves Anti-Tumor Responses in a Phase 2 Prospective Trial of Concurrent or Sequential Stereotactic Radiation and Ipilimumab in Patients with Metastatic Lesions by Barsoumian, H., Cushman, T.R., Caetano, M.D.S., Cadena, A., Younes, A., Tang, C., Simon, G.R., Cortez, M.A., Welsh, J.W.

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Phase II Trial of Low-Dose Radiation for Metastases Progressing on Immunotherapy by Patel, R.R., Guo, C., Hong, D.S., Chang, J.Y., Altan, M., Chun, S.G., Diab, A., Davies, M., Nguyen, Q.N., Barsoumian, H., Simon, G.R., Glitza, I., Tang, C., Verma, V., Comeaux, N., Welsh, J.W.

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NBTXR3 Radiation Enhancing Hafnium Oxide Nanoparticles Activated By Radiotherapy In Combination With Anti-PD-1 Therapy: A Phase I Study by Shen, C., Frakes, J.M., Weiss, J., Caudell, J., Hackman, T., Akulian, J., El-Haddad, G.E., Dixon, R., Hu, Y., Pearson, A., Barsoumian, H., Cortez, M.A., Jameson, K., Said, P., Welsh, J.W., Seiwert, T.

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Abscopal Response Rates after Salvage Radiation in Patients with Progressive Disease on Immunotherapy by Patel, R.R., Guo, C., Hong, D.S., Chang, J.Y., Altan, M., Chun, S.G., Diab, A., Davies, M., Nguyen, Q.N., Barsoumian, H., Simon, G.R., Glitza, I., Tang, C., Verma, V., Comeaux, N., Welsh, J.W.

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Overcoming Resistance to Anti-PD-1 With Tumor Agnostic NBTXR3: From Bench to Bedside by Seiwert, T.Y., Shen, C., Frakes, J.M., Hu, Y., Niu, J., Weiss, J., Caudell, J.J., Barsoumian, H.B., Thariat, J.O., Bonvalot, S., Papai, Z., Cortez, M.A., Zhang, P., Jameson, K., Said, P., Paris, S., Welsh, J.W.

“…Immune checkpoint inhibitors (ICI) can improve outcomes in patients who respond to treatment, however most patients exhibit resistance. Overcoming this…”
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Selective Inhibition of STAT6 With Antisense Nucleotides Enhances Systemic Antitumor Effect of Hypofractionated Radiotherapy and Anti-PD1 in Metastatic Non-Small Cell Lung Cancer by He, K., Barsoumian, H.B., Yang, L., Hu, Y., Osorio, N.P., Sezen, D., Wasley, M.D., Leyton, C.S. Kettlun, Cortez, M.A., Maazi, H., Revenko, A., MacLeod, R., Welsh, J.W.

“…Despite advances in radiotherapy (RT) and immunotherapy, their antitumor activity remains suboptimal in metastatic non-small cell lung cancer (NSCLC). The…”
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Phase II Trial of High-Dose Radiotherapy vs. Low-Dose Radiation, Demonstrating Low-Dose Mediated Immune-Cell Infiltration by He, K., Patel, R.R., Barsoumian, H.B., Chang, J.Y., Tang, C., Comeaux, N.I., Ning, M.S., Gandhi, S., Davies, M., Glitza, I., Hong, D.S., Heymach, J., Nguyen, Q.N., Diab, A., Chun, S.G., Lee, P., Blumenschein, G.R., Fossella, F.V., Chen, D., Welsh, J.W.

“…To report updated findings from a prospective phase II trial of salvage high-dose radiotherapy (HD-RT) with or without low-dose RT (LD-RT) for metastatic…”
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Influence of Low-Dose Radiation on Abscopal Responses in NSCLC Metastases: Analysis of Three Prospective Institutional Trials by Menon, H., Ramapriyan, R., Verma, V., Barsoumian, H., Cushman, T.R., Younes, A., Chen, D., Cortez, M.A., Erasmus, J., de Groot, P., Carter, B.W., Hong, D.S., Diab, A., Glitza, I., Heymach, J., Tang, C., Nguyen, Q.N., Chun, S.G., Welsh, J.W.

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Radiation Followed By an Anti-OX40 Immune Therapy Inhibits Anti-PD1-Resistant Tumors and Promotes Abscopal Effects by Niknam, S., Barsoumian, H., Schoenhals, J., Li, A., Chang, J.Y., Nguyen, Q.N., Gomez, D., Heymach, J., Cortez, M.A., Hwu, P., Welsh, J.W.

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The effect of five antibacterial agents on the physiological levels of serum nitric oxide in mice by Barsoumian, Hampartsoum, El-Rami, Fadi, Abdelnoor, Alexander M

“…In addition to their action on microorganisms, antibacterial agents have been reported to affect host defense mechanisms. Nitric oxide (NO) that is produced by…”
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Mass Conductivity of He-II near the Lambda Point by Barsoumian, K H

“…We employ first sound as a probe to measure the acoustic impedance of 4He in Vycor superleaks for 1.2 K < T < Tλ. Resonance and pulse reflection experiments…”
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