Search Results - "Barski, Oleg A"

The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification by Barski, Oleg A., Tipparaju, Srinivas M., Bhatnagar, Aruni

“…The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and…”
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Role of Aldose Reductase in the Metabolism and Detoxification of Carnosine-Acrolein Conjugates by Baba, Shahid P., Hoetker, Joseph David, Merchant, Michael, Klein, Jon B., Cai, Jian, Barski, Oleg A., Conklin, Daniel J., Bhatnagar, Aruni

“…Oxidation of unsaturated lipids generates reactive aldehydes that accumulate in tissues during inflammation, ischemia, or aging. These aldehydes form covalent…”
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Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress by Vladykovskaya, Elena, Sithu, Srinivas D., Haberzettl, Petra, Wickramasinghe, Nalinie S., Merchant, Michael L., Hill, Bradford G., McCracken, James, Agarwal, Abhinav, Dougherty, Susan, Gordon, Sharon A., Schuschke, Dale A., Barski, Oleg A., O'Toole, Timothy, D'Souza, Stanley E., Bhatnagar, Aruni, Srivastava, Sanjay

“…Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial activation, and they increase the adhesion of the endothelium to…”
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Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue by BABA, Shahid P, BARSKI, Oleg A, AHMED, Yonis, O'TOOLE, Timothy E, CONKLIN, Daniel J, BHATNAGAR, Aruni, SRIVASTAVA, Sanjay

“…Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue Shahid P. Baba , Oleg A. Barski , Yonis…”
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Detoxification of aldehydes by histidine-containing dipeptides: From chemistry to clinical implications by Xie, Zhengzhi, Baba, Shahid P., Sweeney, Brooke R., Barski, Oleg A.

“…Aldehydes are generated by oxidized lipids and carbohydrates at increased levels under conditions of metabolic imbalance and oxidative stress during…”
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Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes by Spite, Matthew, Baba, Shahid P, Ahmed, Yonis, Barski, Oleg A, Nijhawan, Kanchan, Petrash, J Mark, Bhatnagar, Aruni, Srivastava, Sanjay

“…Phospholipid oxidation generates several bioactive aldehydes that remain esterified to the glycerol backbone ('core' aldehydes). These aldehydes induce…”
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Aldose Reductase Protects Against Early Atherosclerotic Lesion Formation in Apolipoprotein E–Null Mice by Srivastava, Sanjay, Vladykovskaya, Elena, Barski, Oleg A, Spite, Matthew, Kaiserova, Karin, Petrash, J Mark, Chung, Stephen S, Hunt, Greg, Dawn, Buddhadeb, Bhatnagar, Aruni

“…RATIONALE:Atherosclerotic lesion formation is associated with the accumulation of oxidized lipids. Products of lipid oxidation, particularly aldehydes,…”
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Characterization of AKR1B16, a novel mouse aldo-keto reductase by Giménez-Dejoz, Joan, Weber, Susanne, Barski, Oleg A., Möller, Gabriele, Adamski, Jerzy, Parés, Xavier, Porté, Sergio, Farrés, Jaume

“…Aldo-keto reductases (AKRs) are distributed in three families and multiple subfamilies in mammals. The mouse Akr1b3 gene is clearly orthologous to human…”
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Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase by Giménez-Dejoz, Joan, Kolář, Michal H, Ruiz, Francesc X, Crespo, Isidro, Cousido-Siah, Alexandra, Podjarny, Alberto, Barski, Oleg A, Fanfrlík, Jindřich, Parés, Xavier, Farrés, Jaume, Porté, Sergio

“…Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well…”
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Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids by Vladykovskaya, Elena, Ozhegov, Evgeny, Hoetker, J. David, Xie, Zhengzhi, Ahmed, Yonis, Suttles, Jill, Srivastava, Sanjay, Bhatnagar, Aruni, Barski, Oleg A.

“…The generation of oxidized phospholipids in lipoproteins has been linked to vascular inflammation in atherosclerotic lesions. Products of phospholipid…”
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Functional expression of novel human and murine AKR1B genes by Salabei, Joshua K., Li, Xiao-Ping, Petrash, J. Mark, Bhatnagar, Aruni, Barski, Oleg A.

“…The Aldo Keto Reductases (AKRs) are a superfamily of enzymes that catalyze the reduction of biogenic and xenobiotic aldehydes and ketones. AKR1B family has 2…”
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Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6) by Xie, Zhengzhi, Barski, Oleg A., Cai, Jian, Bhatnagar, Aruni, Tipparaju, Srinivas M.

“…The β-subunits of the voltage-gated potassium channel (Kvβ) belong to the aldo-keto reductase superfamily. The Kvβ-subunits dock with the pore-forming Kv…”
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Regulation of Ion Channels by Pyridine Nucleotides by Kilfoil, Peter J, Tipparaju, Srinivas M, Barski, Oleg A, Bhatnagar, Aruni

“…Recent research suggests that in addition to their role as soluble electron carriers, pyridine nucleotides [NAD(P)(H)] also regulate ion transport mechanisms…”
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Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice by Barski, Oleg A, Xie, Zhengzhi, Baba, Shahid P, Sithu, Srinivas D, Agarwal, Abhinav, Cai, Jian, Bhatnagar, Aruni, Srivastava, Sanjay

“…Atherosclerotic lesions are associated with the accumulation of reactive aldehydes derived from oxidized lipids. Although inhibition of aldehyde metabolism has…”
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Scaffold Attachment Factor B1 Functions in Development, Growth, and Reproduction by Ivanova, Margarita, Dobrzycka, Klaudia M., Jiang, Shiming, Michaelis, Kai, Meyer, Rene, Kang, Kaiyan, Adkins, Brian, Barski, Oleg A., Zubairy, Simeen, Divisova, Jana, Lee, Adrian V., Oesterreich, Steffi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Developmental expression and function of aldehyde reductase in proximal tubules of the kidney by Barski, Oleg A, Papusha, Victor Z, Ivanova, Margarita M, Rudman, Dorene M, Finegold, Milton J

“…Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate…”
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Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates by Weber, Susanne, Salabei, Joshua K, Möller, Gabriele, Kremmer, Elisabeth, Bhatnagar, Aruni, Adamski, Jerzy, Barski, Oleg A

“…Aldo-keto reductases (AKRs) comprise a superfamily of proteins involved in the reduction and oxidation of biogenic and xenobiotic carbonyls. In humans, at…”
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Catalytic Mechanism and Substrate Specificity of the β-Subunit of the Voltage-Gated Potassium Channel by Tipparaju, Srinivas M, Barski, Oleg A, Srivastava, Sanjay, Bhatnagar, Aruni

“…The β-subunits of voltage-gated potassium (Kv) channels are members of the aldo-keto reductase (AKR) superfamily. These proteins regulate inactivation and…”
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Acrolein consumption induces systemic dyslipidemia and lipoprotein modification by Conklin, Daniel J., Barski, Oleg A., Lesgards, Jean-Francois, Juvan, Peter, Rezen, Tadeja, Rozman, Damjana, Prough, Russell A., Vladykovskaya, Elena, Liu, SiQi, Srivastava, Sanjay, Bhatnagar, Aruni

“…Aldehydes such as acrolein are ubiquitous pollutants present in automobile exhaust, cigarette, wood, and coal smoke. Such aldehydes are also constituents of…”
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Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating by Tipparaju, Srinivas M., Li, Xiao-Ping, Kilfoil, Peter J., Xue, Bin, Uversky, Vladimir N., Bhatnagar, Aruni, Barski, Oleg A.

“…Voltage-gated potassium (Kv) channels are tetrameric assemblies of transmembrane Kv proteins with cytosolic N- and C-termini. The N-terminal domain of Kv1…”
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