Search Results - "Barsh, G. S"

Central nervous system control of food intake and body weight by Cummings, D. E, Baskin, D. G, Schwartz, M. W, Morton, G. J, Barsh, G. S

“…The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the…”
Get full text

Serum amyloid A : production by human white adipocyte and regulation by obesity and nutrition by POITOU, C, VIGUERIE, N, BARSH, G. S, SARIS, W, BRUNEVAL, P, BASDEVANT, A, LANGIN, D, CLEMENT, K, CANCELLO, R, DE MATTEIS, R, CINTI, S, STICH, V, COUSSIEU, C, GAUTHIER, E, COURTINE, M, ZUCKER, J. D

“…The acute-phase proteins, serum amyloid As (SAA), are precursors of amyloid A, involved in the pathogenesis of AA amyloidosis. This work started with the…”
Get full text

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice by LARSSON, N.-G, JIANMING WANG, WILHELMSSON, H, OLDFORS, A, RUSTIN, P, LEWANDOSKI, M, BARSH, G. S, CLAYTON, D. A

“…The regulation of mitochondrial DNA (mtDNA) expression is crucial for mitochondrial biogenesis during development and differentiation. We have disrupted the…”
Get full text

The genetics of pigmentation: from fancy genes to complex traits by Barsh, Gregory S.

“…Genes that control mammalian pigmentation interact with each other in intricate networks that have been studied for decades using mouse coat color mutations…”
Get full text

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein by Ollmann, Michael M., Wilson, Brent D., Yang, Ying-Kui, Kerns, Julie A., Chen, Yanru, Gantz, Ira, Barsh, Gregory S.

“…Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag…”
Get full text

Equivalence in the genetic control of hindbrain segmentation in fish and mouse by Moens, C B, Cordes, S P, Giorgianni, M W, Barsh, G S, Kimmel, C B

“…The vertebrate hindbrain is subdivided into a series of rhombomeres whose segmental organization serves to pattern the architecture and innervation of the…”
Get full text

Molecular and Phenotypic Analysis of Attractin Mutant Mice by Gunn, T. M, Inui, T, Kitada, K, Ito, S, Wakamatsu, K, He, L, Bouley, D. M, Serikawa, T, Barsh, G. S

“…Mutations of the mouse Attractin (Atrn; formerly mahogany) gene were originally recognized because they suppress Agouti pigment type switching. More recently,…”
Get full text

Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain by Bagnol, Didier, Lu, Xin-Yun, Kaelin, Christopher B, Day, Heidi E. W, Ollmann, Michael, Gantz, Ira, Akil, Huda, Barsh, Gregory S, Watson, Stanley J

“…Agouti-related protein (AGRP) is a recently discovered orexigenic neuropeptide that inhibits the binding and action of alpha-melanocyte-stimulating hormone…”
Get full text

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice by Hein, Lutz, Barsh, Gregory S, Pratt, Richard E, Dzau, Victor J, Kobilka, Brian K

“…Angiotensin II, a potent regulator of blood pressure and of water and electrolyte balance, binds to two different G-protein-coupled receptors. The type-1…”
Get full text

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression by Wilhelmsson, Hans, Barsh, Gregory S, Wang, Jianming, Rustin, Pierre, Kahn, C. Ronald, Larsson, Nils-Göran, Li, Hong, Brüning, Jens C, Thorén, Peter, Graff, Caroline, Oldfors, Anders, Clayton, David A

“…Mutations of mitochondrial DNA (mtDNA) cause several well-recognized human genetic syndromes with deficient oxidative phosphorylation and may also have a role…”
Get full text

Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease by Desai, K H, Sato, R, Schauble, E, Barsh, G S, Kobilka, B K, Bernstein, D

“…Manipulations of the murine genome that alter cardiovascular function have created the need for methods to study cardiovascular physiology in genetically…”
Get full text

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation by MILLER, M. W, DUHL, D. M. J, VRIELING, H, CORDES, S. P, OLLMANN, M. M, WINKES, B. M, BARSH, G. S

“…The mouse agouti gene controls the deposition of yellow and black pigment in developing hairs. Several dominant alleles, including lethal yellow (Ay), result…”
Get full text

Genetic Studies of the Mouse Mutations mahogany and mahoganoid by Miller, K. A, Gunn, T. M, Carrasquillo, M. M, Lamoreux, M. L, Galbraith, D. B, Barsh, G. S

“…The mouse mutations mahogany (mg) and mahoganoid (md) are negative modifiers of the Agouti coat color gene, which encodes a paracrine signaling molecule that…”
Get full text

Secreted and Membrane Attractin Result from Alternative Splicing of the Human ATRN Gene by Tang, W., Gunn, T. M., McLaughlin, D. F., Barsh, G. S., Schlossman, S. F., Duke-Cohan, J. S.

“…Attractin, initially identified as a soluble human plasma protein with dipeptidyl peptidase IV activity that is expressed and released by activated T…”
Get full text

Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo by Ollmann, M M, Lamoreux, M L, Wilson, B D, Barsh, G S

“…Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. These…”
Get full text

The mouse mahogany locus encodes a transmembrane form of human attractin by Barsh, Gregory S, Gunn, Teresa M, Miller, Kimberly A, He, Lin, Hyman, Richard W, Davis, Ronald W, Azarani, Arezou, Schlossman, Stuart F, Duke-Cohan, Jonathan S

“…Agouti protein and agouti-related protein are homologous paracrine signalling molecules that normally regulate hair colour and body weight, respectively, by…”
Get full text

Neomorphic agouti mutations in obese yellow mice by Duhl, David M. J, Vrieling, Harry, Miller, Kimberly A, Wolff, George L, Barsh, Gregory S

“…Several dominant mutations of the mouse agouti coat colour gene have pleiotropic effects that include obesity and a yellow coat. The Ay allele is caused by a…”
Get full text

High-Resolution NMR Structure of the Chemically-Synthesized Melanocortin Receptor Binding Domain AGRP(87−132) of the Agouti-Related Protein by McNulty, Joseph C, Thompson, Darren A, Bolin, Kimberly A, Wilken, Jill, Barsh, Gregory S, Millhauser, Glenn L

“…The agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent…”
Get full text

Systematic reanalysis of genomic data improves quality of variant interpretation by Hiatt, S.M., Amaral, M.D., Bowling, K.M., Finnila, C.R., Thompson, M.L., Gray, D.E., Lawlor, J.M.J., Cochran, J.N., Bebin, E.M., Brothers, K.B., East, K.M., Kelley, W.V., Lamb, N.E., Levy, S.E., Lose, E.J., Neu, M.B., Rich, C.A., Simmons, S., Myers, R.M., Barsh, G.S., Cooper, G.M.

“…As genomic sequencing expands, so does our knowledge of the link between genetic variation and disease. Deeper catalogs of variant frequencies improve…”
Get full text

Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues by Marsh, Donald J, Miura, Grant I, Yagaloff, Keith A, Schwartz, Michael W, Barsh, Gregory S, D. Palmiter, Richard

“…Central administration of neuropeptide Y (NPY) potently induces feeding and its abundance in the hypothalamus increases when energy stores fall. Consequently,…”
Get full text