Search Results - "Barry, M. G."

Inactivation of the dnaK gene in Clostridium difficile 630 Δerm yields a temperature-sensitive phenotype and increases biofilm-forming ability by Jain, Shailesh, Smyth, Deborah, O’Hagan, Barry M. G., Heap, John T., McMullan, Geoff, Minton, Nigel P., Ternan, Nigel G.

“…Clostridium difficile infection is a growing problem in healthcare settings worldwide and results in a considerable socioeconomic impact. New hypervirulent…”
Get full text

Microscopic Investigation of the Combined Use of Antibiotics and Biosurfactants on Methicillin Resistant Staphylococcus aureus by Juma, Abulaziz, Lemoine, Patrick, Simpson, Alistair B. J., Murray, Jason, O’Hagan, Barry M. G., Naughton, Patrick J., Dooley, James G., Banat, Ibrahim M.

“…One current strategy to deal with the serious issue of antibiotic resistance is to use biosurfactants, weak antimicrobials in their own right, with antibiotics…”
Get full text

The Effect of High Protein Powder Structure on Hydration, Glass Transition, Water Sorption, and Thermomechanical Properties by Maidannyk, Valentyn A, McSweeney, David J, Montgomery, Sharon, Cenini, Valeria L, O'Hagan, Barry M G, Gallagher, Lucille, Miao, Song, McCarthy, Noel A

“…Poor solubility of high protein milk powders can be an issue during the production of nutritional formulations, as well as for end-users. One possible way to…”
Get full text

Rehydration Properties of Whey Protein Isolate Powders Containing Nanoparticulated Proteins by Guralnick, Jacob R., Panthi, Ram R., Cenini, Valeria L., Mishra, Vinay S. N., O’Hagan, Barry M. G., Crowley, Shane V., O’Mahony, James A.

“…The rehydration properties of original whey protein isolate (WPIC) powder and spray-dried WPI prepared from either unheated (WPIUH) or nanoparticulated WPI…”
Get full text

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir by Eagling, V. A., Back, D. J., Barry, M. G.

“…Aims To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir and indinavir against CYP1A2, CYP2C9, CYP2E1 and CYP3A4 catalysed…”
Get full text

Pilot‐scale production and physicochemical characterisation of spray‐dried nanoparticulated whey protein powders by Guralnick, Jacob R, Panthi, Ram R, Bot, Francesca, Cenini, Valeria L, O’Hagan, Barry MG, Crowley, Shane V, O’Mahony, James A

“…Spray‐dried whey protein isolate (WPI) powders were prepared at pilot‐scale from solutions without heat (WPIUH), heated (WPIH) or heated with calcium (WPIHCa),…”
Get full text

Exploiting a Rose Bengal-bearing, oxygen-producing nanoparticle for SDT and associated immune-mediated therapeutic effects in the treatment of pancreatic cancer by Nicholas, Dean, Nesbitt, Heather, Farrell, Sian, Logan, Keirin, McMullin, Eva, Gillan, Tierna, Kelly, Paul, O'Rourke, Declan, Porter, Simon, Thomas, Keith, O'Hagan, Barry M.G., Nomikou, Nikolitsa, Callan, Bridgeen, Callan, John F., McHale, Anthony P.

“…Rose Bengal-bearing nanoparticles are capable of in situ generation of oxygen in response to the low pH in hypoxic tumours and may be used to elicit a site…”
Get full text

Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro by HOGGARD, P. G, KEWN, S, BARRY, M. G, KHOO, S. H, BACK, D. J

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1 by MOORE, K. H. P, BARRETT, J. E, SHAW, S, PAKES, G. E, CHURCHUS, R, KAPOOR, A, LLOYD, J, BARRY, M. G, BACK, D

“…To assess the pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells (PBMC) from patients infected with HIV-1. Single-center,…”
Get full text

Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, HEAVEY, J, TJIA, J. F, GIBBONS, S. E, BRECKENRIDGE, A. M, BACK, D. J

“…The most important hepatic enzyme involved in the metabolism of protease inhibitors is cytochrome P450 3A4 (CYP3A4). Ritonavir (RIT) is a potent inhibitor of…”
Get full text

Furanone loaded aerogels are effective antibiofilm therapeutics in a model of chronic Pseudomonas aeruginosa wound infection by Proctor, Chris R., Taggart, Megan G., O'Hagan, Barry M.G., McCarron, Paul A., McCarthy, Ronan R., Ternan, Nigel G.

“…Almost 80% of chronic wounds have a bacterial biofilm present. These wound biofilms are caused by a range of organisms and are often polymicrobial. Pseudomonas…”
Get full text

Interaction of sildenafil and indinavir when co-administered to HIV-positive patients by MERRY, C, BARRY, M. G, RYAN, M, TJIA, J. F, HENNESSY, M, EAGLING, V. A, MULCAHY, F, BACK, D. J

“…The prevalence of erectile dysfunction in HIV-infected men is estimated to be 33%. Sildenafil citrate (Viagra; Pfizer Ltd, Sandwich, Kent, UK) is the first…”
Get full text

Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients by MERRY, C, BARRY, M. G, MULCAHY, F, HALIFAX, K. L, BACK, D. J

“…To investigate the pharmacokinetics of saquinavir (SQV) hard gel when administered alone and in combination with nelfinavir (NLF) to HIV-positive patients. Six…”
Get full text

Drug interactions with zidovudine phosphorylation in vitro by HOGGARD, P. G, VEAL, G. J, WILD, M. J, BARRY, M. G, BACK, D. J

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

Detection of hormonal anabolic compounds in calf urine and unverified growth-promoting preparations: application of the AR-LUX bioassay for screening and determination of androgenic activity by Blankvoort, Barry M G, Aarts, Jac M M J G, Schilt, Robert, Geerdink, Peter, Spenkelink, Bert, Rodenburg, Richard J T

“…Despite a ban by the European Union, the use of anabolic steroids and repartitioning agents in cattle is still occasionally observed. Due to continuing…”
Get more information

Lamivudine (3TC) phosphorylation and drug interactions in vitro by Kewn, Stephen, Veal, Gareth J., Hoggard, Patrick G., Barry, Michael G., Back, David J.

“…Lamivudine (2′-deoxy-3′-thiacytidine; 3TC) is a dideoxynucleoside analogue that inhibits the replication of human immunodeficiency virus (HIV). We are…”
Get full text

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites by Barry, M G, Khoo, S H, Veal, G J, Hoggard, P G, Gibbons, S E, Wilkins, E G, Williams, O, Breckenridge, A M, Back, D J

“…Zidovudine (ZDV) requires intracellular phosphorylation to ZDV triphosphate (ZDV-TP) prior to the inhibition of HIV replication. The effect of ZDV dose on the…”
Get more information

Variability in trough plasma saquinavir concentrations in HIV patients--a case for therapeutic drug monitoring by Barry, M G, Merry, C, Lloyd, J, Halifax, K, Carey, P, Mulcahy, F, Back, D J

Get full text

Therapeutic drug monitoring of antiretrovirals in human immunodeficiency virus infection by BACK, D. J, KHOO, S. H, GIBBONS, S. E, BARRY, M. G, MERRY, C

“…The era of antiviral therapy directed against HIV-1 has now entered its second decade. In the twelve years since the FDA approved the first antiretroviral drug…”
Get full text

The pharmacokinetics of combination therapy with nelfinavir plus nevirapine by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, TJIA, J. F, HALIFAX, K. L, BRECKENRIDGE, A. M, BACK, D. J

“…To investigate the pharmacokinetics of nelfinavir (NFV) administered alone and in combination with nevirapine (NVP) to HIV-positive patients. Seven patients…”
Get full text