Search Results - "Barry, Emma F."

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.

“…The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and…”
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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody by Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the…”
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Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription by Thomas, Daniel, Powell, Jason A., Vergez, Francois, Segal, David H., Nguyen, Nhu-Y.N., Baker, Adele, Teh, Tse-Chieh, Barry, Emma F., Sarry, Jean-Emmanuel, Lee, Erwin M., Nero, Tracy L., Jabbour, Anissa M., Pomilio, Giovanna, Green, Benjamin D., Manenti, Stéphane, Glaser, Stefan P., Parker, Michael W., Lopez, Angel F., Ekert, Paul G., Lock, Richard B., Huang, David C.S., Nilsson, Susie K., Récher, Christian, Wei, Andrew H., Guthridge, Mark A.

“…Resistance to cell death is a hallmark of cancer and renders transformed cells resistant to multiple apoptotic triggers. The Bcl-2 family member, Mcl-1, is a…”
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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis by Tvorogov, Denis, Thomas, Daniel, Liau, Nicholas P D, Dottore, Mara, Barry, Emma F, Lathi, Maya, Kan, Winnie L, Hercus, Timothy R, Stomski, Frank, Hughes, Timothy P, Tergaonkar, Vinay, Parker, Michael W, Ross, David M, Majeti, Ravindra, Babon, Jeffrey J, Lopez, Angel F

“…Treatment of patients with myelofibrosis with the type I JAK (Janus kinase) inhibitor ruxolitinib paradoxically induces JAK2 activation loop phosphorylation…”
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High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties by Hercus, Timothy R, Barry, Emma F, Dottore, Mara, McClure, Barbara J, Webb, Andrew I, Lopez, Angel F, Young, Ian G, Murphy, James M

“…Human interleukin-3 (hIL-3) is a polypeptide growth factor that regulates the proliferation, differentiation, survival and function of hematopoietic…”
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Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML by Powell, Jason A., Thomas, Daniel, Barry, Emma F., Kok, Chung H., McClure, Barbara J., Tsykin, Anna, To, L. Bik, Brown, Anna, Lewis, Ian D., Herbert, Kirsten, Goodall, Gregory J., Speed, Terence P., Asou, Norio, Jacob, Bindya, Osato, Motomi, Haylock, David N., Nilsson, Susan K., D'Andrea, Richard J., Lopez, Angel F., Guthridge, Mark A.

“…Deregulated cell survival programs are a classic hallmark of cancer. We have previously identified a serine residue (Ser585) in the βc subunit of the…”
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Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival by Thomas, Daniel, Powell, Jason A, Green, Benjamin D, Barry, Emma F, Ma, Yuefang, Woodcock, Joanna, Fitter, Stephen, Zannettino, Andrew C W, Pitson, Stuart M, Hughes, Timothy P, Lopez, Angel F, Shepherd, Peter R, Wei, Andrew H, Ekert, Paul G, Guthridge, Mark A

“…The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in…”
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14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival by Barry, Emma F., Felquer, Fernando A., Powell, Jason A., Biggs, Lisa, Stomski, Frank C., Urbani, Andrea, Ramshaw, Hayley, Hoffmann, Peter, Wilce, Matthew C., Grimbaldeston, Michele A., Lopez, Angel F., Guthridge, Mark A.

“…Integrated cascades of protein tyrosine and serine/threonine phosphorylation play essential roles in transducing signals in response to growth factors and…”
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Fibroblast Growth Factor Receptor 2 Phosphorylation on Serine 779 Couples to 14-3-3 and Regulates Cell Survival and Proliferation by Lonic, Ana, Barry, Emma F., Quach, Cindy, Kobe, Bostjan, Saunders, Neil, Guthridge, Mark A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells by Jin, Liqing, Lee, Erwin M., Ramshaw, Hayley S., Busfield, Samantha J., Peoppl, Armando G., Wilkinson, Lucy, Guthridge, Mark A., Thomas, Daniel, Barry, Emma F., Boyd, Andrew, Gearing, David P., Vairo, Gino, Lopez, Angel F., Dick, John E., Lock, Richard B.

“…Leukemia stem cells (LSCs) initiate and sustain the acute myeloid leukemia (AML) clonal hierarchy and possess biological properties rendering them resistant to…”
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The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities by Dhagat, Urmi, Hercus, Timothy R, Broughton, Sophie E, Nero, Tracy L, Cheung Tung Shing, Karen S, Barry, Emma F, Thomson, Christy A, Bryson, Steve, Pai, Emil F, McClure, Barbara J, Schrader, John W, Lopez, Angel F, Parker, Michael W

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads…”
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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch by Guthridge, Mark A, Powell, Jason A, Barry, Emma F, Stomski, Frank C, McClure, Barbara J, Ramshaw, Hayley, Felquer, Fernando A, Dottore, Mara, Thomas, Daniel T, To, Bik, Begley, C Glenn, Lopez, Angel F

“…Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood. We have identified a motif in the…”
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The Shc-binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis by Ramshaw, Hayley S., Guthridge, Mark A., Stomski, Frank C., Barry, Emma F., Ooms, Lisa, Mitchell, Christina A., Begley, C. Glenn, Lopez, Angel F.

“…Tyrosine and serine phosphorylation of the common β chain (βc) of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5…”
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The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2 by Guthridge, Mark A., Barry, Emma F., Felquer, Fernando A., McClure, Barbara J., Stomski, Frank C., Ramshaw, Hayley, Lopez, Angel F.

“…We have recently identified a novel mechanism of hematopoietic cell survival that involves site-specific serine phosphorylation of the common beta subunit (βc)…”
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Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis by Tvorogov, Denis, Thomas, Daniel, Liau, Nicholas P.D, Dottore, Mara, Barry, Emma F, Lathi, Maya, Kan, Winnie L, Hercus, Tim R, Stomski, Frank, Hughes, Timothy P., Tergaonkar, Vinay, Parker, Michael W, Ross, David M, Babon, Jeffrey J, Majeti, Ravindra, Lopez, Angel F.

“…Patients with myelofibrosis who are treated with the Type I ATP competitive JAK inhibitor ruxolitinib derive symptomatic benefit from improvement in…”
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78: Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123 by Hercus, Tim R., Broughton, Sophie E., Hardy, Matthew P., Nero, Tracy L., McClure, Barbara J., Dottore, Mara, Dhagat, Urmi, Barry, Emma F., Kan, Winnie L., Busfield, Samantha J., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…The ßc family of cytokines (GM-CSF, IL-3 and IL-5) are largely products of activated T cells and regulate the survival, proliferation, differentiation and…”
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78 by Hercus, Tim R., Broughton, Sophie E., Hardy, Matthew P., Nero, Tracy L., McClure, Barbara J., Dottore, Mara, Dhagat, Urmi, Barry, Emma F., Kan, Winnie L., Busfield, Samantha J., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

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Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival: e1001515 by Thomas, Daniel, Powell, Jason A, Green, Benjamin D, Barry, Emma F, Ma, Yuefang, Woodcock, Joanna, Fitter, Stephen, Zannettino, Andrew CW, Pitson, Stuart M, Hughes, Timothy P, Lopez, Angel F, Shepherd, Peter R, Wei, Andrew H, Ekert, Paul G, Guthridge, Mark A

“…The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in…”
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Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia by Thomas, Daniel, Woodcock, Joanna, Powell, Jason A, Barry, Emma F, Lopez, Angel F, Guthridge, Mark A

“…New therapeutic approaches to acute myeloid leukemia (AML) must ultimately target cell survival pathways in leukemic cells in order to be effective. We have…”
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A Molecular Signature for a Cytokine Receptor Survival Pathway in AML Identifies Unique Prognostic Indicators and Therapeutic Targets by Thomas, Daniel, Powell, Jason A, Barry, Emma F, To, Luen Bik, Lopez, Angel, Guthridge, Mark A

“…The IL-3 receptor regulates myeloid cell survival and proliferation and is overexpressed on AML blasts and CD34+CD38- AML “stem-like” cells suggesting it plays…”
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