Search Results - "Barry, Diana"

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032) by MCPHEE, Fiona, SHEAFFER, Amy K, CHAOQUN CHEN, LEE, Min S, MOSURE, Kathy, SUN, Li-Qiang, SINZ, Michael, MEANWELL, Nicholas A, COLONNO, Richard J, KNIPE, Jay, SCOLA, Paul, FRIBORG, Jacques, HERNANDEZ, Dennis, FALK, Paul, GUANGZHI ZHAI, LEVINE, Steven, CHANIEWSKI, Susan, FEI YU, BARRY, Diana

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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection by Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

“…The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical…”
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection by Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

“…The discovery of BMS-605339 (35), a tripeptidic inhibitor of the NS3/4A enzyme, is described. This compound incorporates a cyclopropyl­acylsulfonamide moiety…”
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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor by Venables, Brian L., Sin, Ny, Wang, Alan Xiangdong, Sun, Li-Qiang, Tu, Yong, Hernandez, Dennis, Sheaffer, Amy, Lee, Min, Dunaj, Cindy, Zhai, Guangzhi, Barry, Diana, Friborg, Jacques, Yu, Fei, Knipe, Jay, Sandquist, Jason, Falk, Paul, Parker, Dawn, Good, Andrew C., Rajamani, Ramkumar, McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.

“…[Display omitted] •P4 ureas give enhanced HCV NS3 potency compared to similar P4 carbamates.•P4 ureas provide for enhanced aqueous solubility compared to…”
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History of cardiology: the steel murmur by Barry, Diana

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