Search Results - "Barroso, Carolina"

Nutritional composition and technological properties determining the quality of different cuts of organic and conventional Turkey meat by Solaesa, Ángela García, García-Barroso, Carolina, Romero, Carlos, González, Cristina, Jiménez, Paula, Pastor, Rosario

“…The aim of this study was to evaluate the nutritional composition and technological properties of meat from turkeys produced under organic conditions and…”
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Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer’s Disease by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach…”
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Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD by García-Barroso, Carolina, Ricobaraza, Ana, Pascual-Lucas, María, Unceta, Nora, Rico, Alberto J., Goicolea, Maria Aranzazu, Sallés, Joan, Lanciego, José Luis, Oyarzabal, Julen, Franco, Rafael, Cuadrado-Tejedor, Mar, García-Osta, Ana

“…Previous studies have demonstrated that cognitive function can be restored in mouse models of Alzheimer's disease (AD) following administration of sildenafil,…”
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Insulin‐like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice by Pascual‐Lucas, Maria, Viana da Silva, Silvia, Di Scala, Marianna, Garcia‐Barroso, Carolina, González‐Aseguinolaza, Gloria, Mulle, Christophe, Alberini, Cristina M, Cuadrado‐Tejedor, Mar, Garcia‐Osta, Ana

“…Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic…”
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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease by Rabal, Obdulia, Sánchez-Arias, Juan A., Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference…”
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Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease by Ugarte, Ana, Gil-Bea, Francisco, García-Barroso, Carolina, Cedazo-Minguez, Ángel, Ramírez, M. Javier, Franco, Rafael, García-Osta, Ana, Oyarzabal, Julen, Cuadrado-Tejedor, Mar

“…Aims Levels of the cyclic nucleotides guanosine 3′, 5′‐monophosphate (cGMP) or adenosine 3′, 5′‐monophosphate (cAMP) that play important roles in memory…”
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Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels by Gómez‐Vallejo, Vanessa, Ugarte, Ana, García‐Barroso, Carolina, Cuadrado‐Tejedor, Mar, Szczupak, Boguslaw, Dopeso‐Reyes, Iria G., Lanciego, José L., García‐Osta, Ana, Llop, Jordi, Oyarzabal, Julen, Franco, Rafael

“…Sildenafil (Viagra) is a selective inhibitor of phosphodiesterase type 5 (PDE5), which degrades cyclic guanosine monophosphate to the linear nucleotide…”
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Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Tan, Haizhong, Wu, Wei, Xu, Musheng, Pineda-Lucena, Antonio, Garcia-Osta, Ana, Oyarzabal, Julen

“…Here, we present a series of dual-target phosphodiesterase 9 (PDE9) and histone deacetylase (HDAC) inhibitors devised as pharmacological tool compounds for…”
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Discovery of in Vivo Chemical Probes for Treating Alzheimer’s Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…In order to determine the contributions of histone deacetylase (HDAC) isoforms to the beneficial effects of dual phosphodiesterase 5 (PDE5) and pan-HDAC…”
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Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease by Cuadrado-Tejedor, Mar, Pérez-González, Marta, García-Muñoz, Cristina, Muruzabal, Damián, García-Barroso, Carolina, Rabal, Obdulia, Segura, Víctor, Sánchez-Arias, Juan A, Oyarzabal, Julen, Garcia-Osta, Ana

“…The discouraging results with therapies for Alzheimer's disease (AD) in clinical trials, highlights the urgent need to adopt new approaches. Like other complex…”
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The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacterial Infections and Iron Disorders by Barroso, Carolina, Carvalho, Pedro, Nunes, Magda, Gonçalves, José F M, Rodrigues, Pedro N S, Neves, João V

“…The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic…”
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The Diverse Piscidin Repertoire of the European Sea Bass ( Dicentrarchus labrax ): Molecular Characterization and Antimicrobial Activities by Barroso, Carolina, Carvalho, Pedro, Carvalho, Carla, Santarém, Nuno, Gonçalves, José F M, Rodrigues, Pedro N S, Neves, João V

“…Fish rely on their innate immune responses to cope with the challenging aquatic environment, with antimicrobial peptides (AMPs) being one of the first line of…”
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A role for hepcidin in the anemia caused by Trypanosoma brucei infection by Neves, João V, Gomes, Ana C, Costa, David M, Barroso, Carolina, Vaulont, Sophie, Cordeiro da Silva, Anabela, Tavares, Joana, Rodrigues, Pedro N S

“…Trypanosomiasis is a parasitic disease affecting both humans and animals in the form of Human African Trypanosomiasis and Nagana disease, respectively. Anemia…”
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Characterization of Erythroferrone in a Teleost Fish ( Dicentrarchus labrax ) With Two Functional Hepcidin Types: More Than an Erythroid Regulator by Neves, João V, Barroso, Carolina, Carvalho, Pedro, Nunes, Magda, Gonçalves, José F M, Rodrigues, Pedro N S

“…Erythroferrone is a recently identified erythroid regulator produced by erythroblasts in the mammalian bone marrow and extramedullary sites, known to be…”
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Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease by García-Osta, Ana, Cuadrado-Tejedor, Mar, García-Barroso, Carolina, Oyarzábal, Julen, Franco, Rafael

“…Alzheimer’s disease (AD) is the most common form of dementia among the elderly. In AD patients, memory loss is accompanied by the formation of beta-amyloid…”
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Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax) by Barroso, Carolina, Carvalho, Pedro, Gonçalves, José F. M., Rodrigues, Pedro N. S., Neves, João V.

“…Beta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with…”
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Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa by Lorusso, Andre Bittencourt, Carrara, João Antônio, Barroso, Carolina Deuttner Neumann, Tuon, Felipe Francisco, Faoro, Helisson

“…Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in parallel with new antibiotics, leading to a major global public health…”
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Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota by Cabrita, Ana R. J., Barroso, Carolina, Fontes-Sousa, Ana Patrícia, Correia, Alexandra, Teixeira, Luzia, Maia, Margarida R. G., Vilanova, Manuel, Yergaliyev, Timur, Camarinha-Silva, Amélia, Fonseca, António J. M.

“…Locally produced fish hydrolysate and oil from the agrifood sector comprises a sustainable solution both to the problem of fish waste disposal and to the…”
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Phosphodiesterase inhibition in cognitive decline by García-Barroso, Carolina, Ugarte, Ana, Martínez, Martín, Rico, Alberto J, Lanciego, José Luis, Franco, Rafael, Oyarzabal, Julen, Cuadrado-Tejedor, Mar, García-Osta, Ana

“…Understanding the cellular and molecular processes involved in learning and memory will help in the development of safe and effective cognitive enhancers. The…”
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Ancestry of victims of 1755 Lisbon earthquake based on tooth morphology by Palmela Pereira, Cristiana, Bento, Beatriz A F, Barroso Flamino, Carolina, Santos, Rui, Telles Antunes, Miguel, Scott, Richard G

“…The present investigation comprises the characterization of skeletal remains recovered from the 2004 archaeological excavations carried out in the Cloister's…”
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